Publications by authors named "Thorsten Kirschberg"

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Selective thyroid hormone receptor β agonists with oxadiazolone acid isosteres.
Thorsten A Kirschberg, Christopher T Jones, Yingzi Xu, Martijn Fenaux, Randall L Halcomb

Bioorg Med Chem Lett· November 2020

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Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment.
Joy Y Feng, Ting Wang, Yeojin Park, Darius Babusis, Gabriel Birkus, Thorsten Kirschberg

Antimicrob Agents Chemother· August 2018

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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.
Weimei Xing, Ona Barauskas, Thorsten Kirschberg, Anita Niedziela-Majka, Michael Clarke

PLoS One· October 2017

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Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Thorsten A Kirschberg, Sammy Metobo, Michael O Clarke, Vangelis Aktoudianakis, Darius Babusis

Bioorg Med Chem Lett· April 2017

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Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.
Thorsten A Kirschberg, Michael Mish, Neil H Squires, Sebastian Zonte, Evangelos Aktoudianakis

Nucleosides Nucleotides Nucleic Acids· August 2016

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Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection.
John O Link, James G Taylor, Lianhong Xu, Michael Mitchell, Hongyan Guo, Thorsten Kirschberg

J Med Chem· August 2016

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Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent.
Hyock Joo Kwon, Weimei Xing, Katie Chan, Anita Niedziela-Majka, Katherine M Brendza, Thorsten Kirschberg

PLoS One· December 2015

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Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
Thorsten A Kirschberg, Michael R Mish, Lijun Zhang, Neil H Squires, Ke-Yu Wang

Bioorg Med Chem Lett· March 2015

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Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
Michael R Mish, Aesop Cho, Thorsten Kirschberg, Jie Xu, C Sebastian Zonte

Bioorg Med Chem Lett· July 2014

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Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.
John O Link, James G Taylor, Lianhong Xu, Michael Mitchell, Hongyan Guo, Thorsten Kirschberg

J Med Chem· March 2014

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Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease.
Thorsten A Kirschberg, Neil H Squires, Huiling Yang, Amoreena C Corsa, Yang Tian

Bioorg Med Chem Lett· February 2014

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Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
Eric B Lansdon, Qi Liu, Stephanie A Leavitt, Mini Balakrishnan, Jason K Perry, Thorsten A Kirschberg

Antimicrob Agents Chemother· June 2011

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RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
Thorsten A Kirschberg, Mini Balakrishnan, Neil H Squires, Tiffany Barnes, Katherine M Brendza

J Med Chem· October 2009

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Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.
Thorsten A Kirschberg, Mini Balakrishnan, Wei Huang, Rebecca Hluhanich, Nilima Kutty

Bioorg Med Chem Lett· February 2008

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Metal chelators as antiviral agents.
Thorsten Kirschberg, Jay Parrish

Curr Opin Drug Discov Devel· July 2007

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Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.
William J Watkins, James M Chen, Aesop Cho, Lee Chong, Nicole Collins, Thorsten Kirschberg

Bioorg Med Chem Lett· July 2006

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Use of benzofuran for concomitant protection of aldehyde and phenol groups in the preparation of mycophenolic acid analogues.
Maria Fardis, Michael Mertzman, William Thomas, Thorsten Kirschberg, Nicole Collins

J Org Chem· June 2006

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Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates.
Thorsten A Kirschberg, Chris L VanDeusen, Jonathan B Rothbard, Michael Yang, Paul A Wender

Org Lett· September 2003

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Photoinduced Electron Transfer Reactions of alpha-Cyclopropyl- and alpha-Epoxy Ketones. Tandem Fragmentation-Cyclization to Bi-, Tri-, and Spirocyclic Ketones.
Thorsten Kirschberg, Jochen Mattay

J Org Chem· December 1996

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