Publications by authors named "Randall L Halcomb"

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Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis.
Eda Canales, Winston Tse, Scott D Schroeder, Chien-Hung Chou, Qi Liu, Randall L Halcomb

J Med Chem· October 2025

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Selective thyroid hormone receptor β agonists with oxadiazolone acid isosteres.
Thorsten A Kirschberg, Christopher T Jones, Yingzi Xu, Martijn Fenaux, Randall L Halcomb

Bioorg Med Chem Lett· November 2020

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Clinical targeting of HIV capsid protein with a long-acting small molecule.
John O Link, Martin S Rhee, Winston C Tse, Jim Zheng, John R Somoza, Randall L Halcomb

Nature· August 2020

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The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
F Anthony Romero, Christopher T Jones, Yingzi Xu, Martijn Fenaux, Randall L Halcomb

J Med Chem· May 2020

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Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.
Christopher R Behrens, Edward H Ha, Lawrence L Chinn, Simeon Bowers, Gary Probst, Randall L Halcomb

Mol Pharm· November 2015

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Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses.
Abigail Fosdick, Jim Zheng, Stefan Pflanz, Christian R Frey, Joseph Hesselgesser, Randall L Halcomb

J Pharmacol Exp Ther· January 2014

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Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.
Paul A Roethle, Ryan M McFadden, Hong Yang, Paul Hrvatin, Hon Hui, Randall L Halcomb

J Med Chem· September 2013

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GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.
Robert E Lanford, Bernadette Guerra, Deborah Chavez, Luis Giavedoni, Vida L Hodara, Randall L Halcomb

Gastroenterology· June 2013

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Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha.
Kristi Kincaid, Jeff Beckman, Aleksandra Zivkovic, Randall L Halcomb, Joachim W Engels

Nucleic Acids Res· May 2005

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Synthesis of an isostere of an O-linked glycopeptide.
Lisa J Whalen, Randall L Halcomb

Org Lett· September 2004

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A new method for the stereoselective synthesis of alpha-substituted serine amino acid analogues.
Jonathan W Lane, Randall L Halcomb

Org Lett· October 2003

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Total synthesis of (+)-phomactin a using a B-alkyl Suzuki macrocyclization.
Peter J Mohr, Randall L Halcomb

J Am Chem Soc· February 2003

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Stereoselective synthesis of conformationally constrained glycosylated amino acids using an enzyme-catalyzed desymmetrization.
Jonathan W Lane, Randall L Halcomb

J Org Chem· February 2003

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Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases.
Lisa J Whalen, Kerry A McEvoy, Randall L Halcomb

Bioorg Med Chem Lett· January 2003

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Convergent enantioselective synthesis of the tricyclic core of phomactin A.
Peter J Mohr, Randall L Halcomb

Org Lett· July 2002

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Application of serine- and threonine-derived cyclic sulfamidates for the preparation of S-linked glycosyl amino acids in solution- and solid-phase peptide synthesis.
Scott B Cohen, Randall L Halcomb

J Am Chem Soc· March 2002

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