Publications by authors named "Jeff Beckman"

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Navigating atypical equilibrium dynamics of protein aggregates for biopharmaceutical release and stability monitoring.
Yiting Zhang, Ruojia Li, Hangtian Song, Andrew McClain, Richard Ludwig, Jeff Beckman

J Chromatogr B Analyt Technol Biomed Life Sci· December 2025

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Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis.
Andrew McClain, Yiting Zhang, Yan Yin, Qi Wang, Lih-Yueh Hwang, Jeff Beckman

Anal Chem· December 2022

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Enhancement of covalent aggregate quantification of protein therapeutics by non-reducing capillary gel electrophoresis using sodium hexadecyl sulfate (CE-SHS).
Qian Guan, Ryan Knihtila, Jennifer Atsma, Rekha Tulsan, Surinder Singh, Jeff Beckman

J Chromatogr B Analyt Technol Biomed Life Sci· September 2020

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Minimization of artifact protein aggregation using tetradecyl sulfate and hexadecyl sulfate in capillary gel electrophoresis under reducing conditions.
Qian Guan, Jennifer Atsma, Rekha Tulsan, Sergey Voronov, Julia Ding, Jeff Beckman

Electrophoresis· July 2020

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New Immobilization Guidelines Change EMS Critical Thinking in Older Adults With Spine Trauma.
Linda Underbrink, Alice Twink Dalton, Jan Leonard, Pamela W Bourg, Abigail Blackmore, Jeff Beckman

Prehosp Emerg Care· April 2019

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Purity Determination by Capillary Electrophoresis Sodium Hexadecyl Sulfate (CE-SHS): A Novel Application For Therapeutic Protein Characterization.
Jeff Beckman, Yuanli Song, Yan Gu, Sergey Voronov, Naresh Chennamsetty

Anal Chem· February 2018

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Using a fluorescent cytosine analogue tC(o) to probe the effect of the Y567 to Ala substitution on the preinsertion steps of dNMP incorporation by RB69 DNA polymerase.
Shuangluo Xia, Jeff Beckman, Jimin Wang, William H Konigsberg

Biochemistry· June 2012

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Structure of the 2-aminopurine-cytosine base pair formed in the polymerase active site of the RB69 Y567A-DNA polymerase.
Linda J Reha-Krantz, Chithra Hariharan, Usharani Subuddhi, Shuangluo Xia, Chao Zhao, Jeff Beckman

Biochemistry· November 2011

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Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP and dGMP to be inserted opposite Guanidinohydantoin .
Jeff Beckman, Mina Wang, Gregor Blaha, Jimin Wang, William H Konigsberg

Biochemistry· October 2010

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Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine .
Jeff Beckman, Mina Wang, Gregor Blaha, Jimin Wang, William H Konigsberg

Biochemistry· May 2010

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Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation.
Huidong Zhang, Jeff W Beckman, F Peter Guengerich

J Biol Chem· December 2009

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RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity.
Hong Zhang, Jeff Beckman, Jimin Wang, William Konigsberg

Biochemistry· July 2009

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Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.
Michael Trostler, Alison Delier, Jeff Beckman, Milan Urban, Jennifer N Patro

Biochemistry· June 2009

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Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence.
Jeff W Beckman, Qixin Wang, F Peter Guengerich

J Biol Chem· December 2008

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Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.
Jeff Beckman, Kristi Kincaid, Michal Hocek, Thomas Spratt, Joachim Engels

Biochemistry· January 2007

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Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha.
Kristi Kincaid, Jeff Beckman, Aleksandra Zivkovic, Randall L Halcomb, Joachim W Engels

Nucleic Acids Res· May 2005

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