Publications by authors named "Martin Klima"

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SPR is a fast and straightforward method to estimate the binding constants of cyclic dinucleotides to their binding partners, such as STING or poxin.
Hagen Sülzen, Martin Klima, Vojtech Duchoslav, Evzen Boura

Biophys Chem· April 2025

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Molecular dynamics of evaporative cooling of water clusters.
Martin Klíma, Jiří Janek, Jiří Kolafa

Phys Chem Chem Phys· February 2025

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Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39.
Eva Zilecka, Martin Klima, Milan Stefek, Milan Dejmek, Radim Nencka

J Struct Biol X· December 2024

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Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase.
Kateřina Krejčová, Petra Krafcikova, Martin Klima, Dominika Chalupska, Karel Chalupsky

Structure· August 2024

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Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Martin Klima, Milan Dejmek, Vojtech Duchoslav, Andrea Eisenreichova, Michal Sala

Structure· April 2024

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Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors.
AkshatKumar Nigam, Matthew F D Hurley, Fengling Li, Eva Konkoľová, Martin Klíma

bioRxiv· January 2024

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Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Milan Dejmek, Andrea Brazdova, Tomáš Otava, Marketa Pimkova Polidarova, Martin Klíma

Eur J Med Chem· November 2023

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Properties of water and argon clusters developed in supersonic expansions.
Martin Klíma, David Celný, Jiří Janek, Jiří Kolafa

J Chem Phys· September 2023

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Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39.
Petr Skvara, Dominika Chalupska, Martin Klima, Jan Kozic, Jan Silhan

Antiviral Res· August 2023

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Does the Sign of Charge Affect the Surface Affinity of Simple Ions?
György Hantal, Martin Klíma, Louisa McFegan, Jiří Kolafa, Pál Jedlovszky

J Phys Chem B· July 2023

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Crystal Structure of the ORP8 Lipid Transport ORD Domain: Model of Lipid Transport.
Andrea Eisenreichova, Martin Klima, Midhun Mohan Anila, Alena Koukalova, Jana Humpolickova

Cells· July 2023

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Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes.
Stepan Kortus, Kristyna Rehakova, Martin Klima, Marharyta Kolcheva, Marek Ladislav

J Neurosci· June 2023

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SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses.
Fengling Li, Pegah Ghiabi, Taraneh Hajian, Martin Klima, Alice Shi Ming Li

Biochim Biophys Acta Gen Subj· April 2023

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Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Jan Silhan, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska

Nat Commun· April 2023

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The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.
Marharyta Kolcheva, Marek Ladislav, Jakub Netolicky, Stepan Kortus, Kristyna Rehakova, Martin Klima

Neuropharmacology· January 2023

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Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.
Mbilo Misehe, Martin Klima, Marika Matoušová, Dominika Chalupská, Milan Dejmek

Bioorg Med Chem Lett· November 2022

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The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-β-synthase domain.
Zdeněk Knejzlík, Michal Doležal, Klára Herkommerová, Kamila Clarova, Martin Klíma

FEBS J· September 2022

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Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
Martin Klima, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau, Taraneh Hajian

Protein Sci· September 2022

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Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Milan Dejmek, Michal Šála, Andrea Brazdova, Lenka Vanekova, Miroslav Smola

Structure· August 2022

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Coronaviral RNA-methyltransferases: function, structure and inhibition.
Radim Nencka, Jan Silhan, Martin Klima, Tomas Otava, Hugo Kocek

Nucleic Acids Res· January 2022

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Molecular Dynamics of Heterogeneous Systems on GPUs and Their Application to Nucleation in Gas Expanding to a Vacuum.
David Celný, Martin Klíma, Jiří Kolafa

J Chem Theory Comput· December 2021

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Localization of SARS-CoV-2 Capping Enzymes Revealed by an Antibody against the nsp10 Subunit.
Vladimira Horova, Barbora Landova, Jan Hodek, Karel Chalupsky, Petra Krafcikova, Martin Klima

Viruses· July 2021

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Structural analysis of the putative SARS-CoV-2 primase complex.
Eva Konkolova, Martin Klima, Radim Nencka, Evzen Boura

J Struct Biol· August 2020

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Structural basis for hijacking of the host ACBD3 protein by bovine and porcine enteroviruses and kobuviruses.
Miroslav Smola, Vladimira Horova, Evzen Boura, Martin Klima

Arch Virol· February 2020

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Structural insights into Acyl-coenzyme A binding domain containing 3 (ACBD3) protein hijacking by picornaviruses.
Dominika Chalupska, Bartosz Różycki, Martin Klima, Evzen Boura

Protein Sci· December 2019

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