Publications by authors named "Garrick Packard"

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1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties.
Christian Nilewski, Theodore D Michels, Garrick K Packard, Alan X Xiang, Paul A Sprengeler

Bioorg Med Chem Lett· September 2021

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Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Peggy A Thompson, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen, Garrick K Packard

Mol Cancer Ther· January 2021

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Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors.
Christian Nilewski, Theodore D Michels, Alan X Xiang, Garrick K Packard, Paul A Sprengeler

Org Lett· August 2020

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Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
Justin T Ernst, Peggy A Thompson, Christian Nilewski, Paul A Sprengeler, Samuel Sperry, Garrick Packard

J Med Chem· June 2020

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A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation.
Gregory D Ferguson, Mercedes Delgado, Veronique Plantevin-Krenitsky, Kristen Jensen-Pergakes, R J Bates, Garrick Packard

PLoS One· July 2016

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Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
Deborah S Mortensen, Sophie M Perrin-Ninkovic, Graziella Shevlin, Jingjing Zhao, Garrick Packard

J Med Chem· July 2015

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Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.
Deborah S Mortensen, Sophie M Perrin-Ninkovic, Graziella Shevlin, Jan Elsner, Jingjing Zhao, Garrick Packard

J Med Chem· July 2015

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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.
Deborah S Mortensen, Kimberly E Fultz, Shuichan Xu, Weiming Xu, Garrick Packard

Mol Cancer Ther· June 2015

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Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
Garrick K Packard, Patrick Papa, Jennifer R Riggs, Paul Erdman, Lida Tehrani

Bioorg Med Chem Lett· January 2012

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Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.
Sheela A Thomas, Tongmei Li, Keith W Woods, Xiaohong Song, Garrick Packard

Bioorg Med Chem Lett· July 2006

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Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Qun Li, Keith W Woods, Sheela Thomas, Gui-Dong Zhu, Garrick Packard

Bioorg Med Chem Lett· April 2006

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A unified approach to polyene macrolides: synthesis of candidin and nystatin polyols.
Isao Kadota, Yueqing Hu, Garrick K Packard, Scott D Rychnovsky

Proc Natl Acad Sci U S A· August 2004

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Synthesis of rimocidinolide methyl ester, the aglycone of (+)-rimocidin.
Garrick K Packard, Yueqing Hu, Andrea Vescovi, Scott D Rychnovsky

Angew Chem Int Ed Engl· May 2004

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