Publications by authors named "Gary Layton"

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A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics.
David L Hava, Lisa Tan, Patrick Johnson, Aidan K Curran, Jason Perry, Gary Layton

Br J Clin Pharmacol· April 2020

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A Phase 1b Trial to Assess the Pharmacokinetics of Ezutromid in Pediatric Duchenne Muscular Dystrophy Patients on a Balanced Diet.
Francesco Muntoni, Bina Tejura, Stefan Spinty, Helen Roper, Imelda Hughes, Gary Layton

Clin Pharmacol Drug Dev· October 2019

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Efficacy and safety of the histamine H receptor antagonist ZPL-3893787 in patients with atopic dermatitis.
Thomas Werfel, Gary Layton, Michael Yeadon, Lyndsey Whitlock, Ian Osterloh

J Allergy Clin Immunol· May 2019

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Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.
Joanna M Zakrzewska, Joanne Palmer, Valerie Morisset, Gerard Mp Giblin, Mark Obermann, Gary Layton

Lancet Neurol· April 2017

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Safety, Tolerability, and Pharmacokinetics of SMT C1100, a 2-Arylbenzoxazole Utrophin Modulator, following Single- and Multiple-Dose Administration to Pediatric Patients with Duchenne Muscular Dystrophy.
Valeria Ricotti, Stefan Spinty, Helen Roper, Imelda Hughes, Bina Tejura, Gary Layton

PLoS One· August 2016

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P2X3 receptor antagonist in chronic cough--Authors' reply.
Jaclyn A Smith, Rayid Abdulqawi, Rachel Dockry, Kimberley Holt, Gary Layton

Lancet· July 2015

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Pharmacokinetic interactions between lersivirine and zidovudine, tenofovir disoproxil fumarate/emtricitabine and abacavir/lamivudine.
Manoli Vourvahis, John Davis, Grant Langdon, Gary Layton, Juanzhi Fang

Antivir Ther· April 2015

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P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study.
Rayid Abdulqawi, Rachel Dockry, Kimberley Holt, Gary Layton, Bruce G McCarthy

Lancet· March 2015

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Effects of multiple doses of voriconazole on the vision of healthy volunteers: a double-blind, placebo-controlled study.
Eberhart Zrenner, Konrad Tomaszewski, Julia Hamlin, Gary Layton, Nolan Wood

Ophthalmic Res· December 2014

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Long-term sildenafil added to intravenous epoprostenol in patients with pulmonary arterial hypertension.
Gérald Simonneau, Lewis J Rubin, Nazzareno Galiè, Robyn J Barst, Thomas R Fleming, Gary R Layton

J Heart Lung Transplant· July 2014

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STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension.
Robyn J Barst, Maurice Beghetti, Tomas Pulido, Gary Layton, Irina Konourina

Circulation· May 2014

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The effect of lersivirine, a next-generation NNRTI, on the pharmacokinetics of midazolam and oral contraceptives in healthy subjects.
John Davis, Grant Langdon, Gary Layton, Chew Lan Chong, Marie-Noella Ndongo

Eur J Clin Pharmacol· November 2012

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Effect of rifampin and rifabutin on the pharmacokinetics of lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-O-desacetyl-rifabutin in healthy subjects.
Manoli Vourvahis, John Davis, Rong Wang, Gary Layton, Heng Wee Choo

Antimicrob Agents Chemother· August 2012

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Effects of ketoconazole and valproic acid on the pharmacokinetics of the next generation NNRTI, lersivirine (UK-453,061), in healthy adult subjects.
Grant Langdon, John Davis, Gary Layton, Chew-Lan Chong, Georges Weissgerber

Br J Clin Pharmacol· May 2012

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The pharmacokinetics of lersivirine (UK-453,061) and HIV-1 protease inhibitor coadministration in healthy subjects.
Manoli Vourvahis, Grant Langdon, Gary Layton, Robert R Labadie, Heng Wee Choo

J Acquir Immune Defic Syndr· May 2012

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Pharmacokinetic effects of coadministration of lersivirine with raltegravir or maraviroc in healthy subjects.
Manoli Vourvahis, Grant Langdon, Robert R Labadie, Gary Layton, Marie-Noella Ndongo

Antimicrob Agents Chemother· February 2012

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A randomized, double-blind, placebo-controlled, dose-ranging study of oral sildenafil citrate in treatment-naive children with pulmonary arterial hypertension.
Robyn J Barst, D Dunbar Ivy, Guillermo Gaitan, Andras Szatmari, Andrzej Rudzinski, Gary R Layton

Circulation· January 2012

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Long-term treatment with sildenafil citrate in pulmonary arterial hypertension: the SUPER-2 study.
Lewis J Rubin, David B Badesch, Thomas R Fleming, Nazzareno Galiè, Gerald Simonneau, Gary Layton

Chest· November 2011

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Safety, tolerability and pharmacokinetics of an intravenous bolus of sildenafil in patients with pulmonary arterial hypertension.
Jean-Luc Vachiery, Sandrine Huez, Hunter Gillies, Gary Layton, Naoto Hayashi

Br J Clin Pharmacol· February 2011

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A randomized, controlled, multicentre trial comparing pegvisomant alone with combination therapy of pegvisomant and long-acting octreotide in patients with acromegaly.
Peter J Trainer, Shereen Ezzat, Gwyn A D'Souza, Gary Layton, Christian J Strasburger

Clin Endocrinol (Oxf)· October 2009

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Activity, pharmacokinetics and safety of lersivirine (UK-453,061), a next-generation nonnucleoside reverse transcriptase inhibitor, during 7-day monotherapy in HIV-1-infected patients.
Gerd Fätkenheuer, Schlomo Staszewski, Andreas Plettenburg, Frances Hackman, Gary Layton

AIDS· October 2009

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Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects.
John D Davis, Frances Hackman, Gary Layton, Tracy Higgins, David Sudworth

Br J Clin Pharmacol· April 2008

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Efficacy and tolerability of sumanirole in restless legs syndrome: a phase II, randomized, double-blind, placebo-controlled, dose-response study.
Diego Garcia-Borreguero, John Winkelman, Alieu Adams, Amanda Ellis, Mark Morris, Gary Layton

Sleep Med· March 2007

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A comparison of sumanirole versus placebo or ropinirole for the treatment of patients with early Parkinson's disease.
Carlos Singer, Janice Lamb, Amanda Ellis, Gary Layton,

Mov Disord· March 2007

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Man versus machine: is there an optimal method for QT measurements in thorough QT studies?
Borje Darpo, Marilyn Agin, David J Kazierad, Gary Layton, Gary Muirhead

J Clin Pharmacol· June 2006

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