Publications by authors named "Geoff Kelly"

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V
Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating.
David Hollingworth, Karl F Herold, Geoff Kelly, Vitaliy B Mykhaylyk, Donghang Zhang

bioRxiv· April 2025

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Author Correction: Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.
Mohamed Ismail, Stephen R Martin, Roger George, Francesca Houghton, Geoff Kelly

Sci Rep· March 2025

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NMR assignment of the conserved bacterial DNA replication protein DnaA domain IV.
Alexander Nguyen Abrams, Geoff Kelly, Julia Hubbard

Biomol NMR Assign· December 2024

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Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole.
David Hollingworth, Frances Thomas, Dana A Page, Mohamed A Fouda, Raquel Lopez-Rios De Castro, Geoff Kelly

Nat Commun· September 2024

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High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of Paired Clinical Liver Tissue Samples from Hepatocellular Cancer and Surrounding Region.
Wendy M Fernandes, Nicola Harris, Ane Zamalloa, Lissette Adofina, Parthi Srinivasan, Geoff Kelly

Int J Mol Sci· August 2024

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The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans.
Saima Rehman, Anna Katarina Antonovic, Ian E McIntire, Huaixin Zheng, Leanne Cleaver, Geoff Kelly

Nat Commun· June 2024

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Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Oliver J Acton, Devon Sheppard, Simone Kunzelmann, Sarah J Caswell, Andrea Nans, Geoff Kelly

Nat Commun· May 2024

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Targeting the UCHL3 ubiquitin hydrolase using chemically constrained peptides.
Harry R King, Mark Bycroft, Thanh-Binh Nguyen, Geoff Kelly, Alexander A Vinogradov

Proc Natl Acad Sci U S A· May 2024

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The structural properties of full-length annexin A11.
Erika F Dudas, Mark D Tully, Tamas Foldes, Geoff Kelly, Gian Gaetano Tartaglia

Front Mol Biosci· March 2024

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The collagen-like protein employs a unique binding mechanism for the recognition of host glycosaminoglycans.
Saima Rehman, Anna K Antonovic, Ian E McIntire, Huaixin Zheng, Leanne Cleaver, Geoff Kelly

bioRxiv· December 2023

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Affinity-enhanced RNA-binding domains as tools to understand RNA recognition.
Belén Chaves-Arquero, Katherine M Collins, Giancarlo Abis, Geoff Kelly, Evangelos Christodoulou

Cell Rep Methods· June 2023

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Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells.
Ming-Han C Tsai, Sarah J Caswell, Elizabeth R Morris, Melanie C Mann, Simon Pennell, Geoff Kelly

Retrovirology· May 2023

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Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.
Mohamed Ismail, Stephen R Martin, Roger George, Francesca Houghton, Geoff Kelly

Sci Rep· February 2023

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Sequence-specific H, C and N backbone NMR assignments for the N-terminal IgV-like domain (D1) and full extracellular region (D1D2) of PD-L1.
Kayleigh Walker, Lorna C Waters, Geoff Kelly, Frederick W Muskett, Mark D Carr

Biomol NMR Assign· October 2022

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C
CP-MAS and Solution NMR Studies of Allosteric Communication in CA-assemblies of HIV-1.
Giuseppe Nicastro, Massimo Lucci, Alain Oregioni, Geoff Kelly, Tom A Frenkiel

J Mol Biol· August 2022

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Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9.
Erika F Dudás, Rita Puglisi, Sophie Marianne Korn, Caterina Alfano, Maria Laura Bellone, Geoff Kelly

Biomol NMR Assign· October 2021

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Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R- and S-dNTPαS Diastereomers.
Elizabeth R Morris, Simone Kunzelmann, Sarah J Caswell, Andrew G Purkiss, Geoff Kelly

Biochemistry· June 2021

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Targeting the nucleotide salvage factor DNPH1 sensitizes -deficient cells to PARP inhibitors.
Kasper Fugger, Ilirjana Bajrami, Mariana Silva Dos Santos, Sarah Jane Young, Simone Kunzelmann, Geoff Kelly

Science· April 2021

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Genome Analysis of Melon Necrotic Spot Virus Incursions and Seed Interceptions in Australia.
Joanne Mackie, Ellena Higgins, Grant A Chambers, Len Tesoriero, Ramez Aldaoud, Geoff Kelly

Plant Dis· July 2020

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Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α-TAB1 Complexes.
Charlie Nichols, Joseph Ng, Annika Keshu, Geoff Kelly, Maria R Conte

J Med Chem· July 2020

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D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.
Cesira de Chiara, Miha Homšak, Gareth A Prosser, Holly L Douglas, Acely Garza-Garcia, Geoff Kelly

Nat Chem Biol· June 2020

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Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Elizabeth R Morris, Sarah J Caswell, Simone Kunzelmann, Laurence H Arnold, Andrew G Purkiss, Geoff Kelly

Nat Commun· June 2020

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LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
Isabel Cruz-Gallardo, Luigi Martino, Geoff Kelly, R Andrew Atkinson, Roberta Trotta

Nucleic Acids Res· May 2019

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IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.
Robert Dagil, Neil J Ball, Roksana W Ogrodowicz, Fruzsina Hobor, Andrew G Purkiss, Geoff Kelly

Nucleic Acids Res· May 2019

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Resonance assignment of human LARP4A La module.
Isabel Cruz-Gallardo, Luigi Martino, Roberta Trotta, Stefano De Tito, Geoff Kelly

Biomol NMR Assign· April 2019

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