Publications by authors named "Mark D Carr"

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Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.
Daniel J Shaw, Lorna C Waters, Sarah L Strong, Monika-Sarah E D Schulze, Gregory M Greetham, Mark D Carr

Chem Sci· July 2023

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Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery.
Kayleigh Walker, Roberta Baravalle, Rachel Holyfield, Jacqueline Kalms, Helena Wright, Mark D Carr

Front Immunol· July 2023

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Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling.
Richard Cowan, Martina Trokter, Arkadiusz Oleksy, Marina Fedorova, Kovilen Sawmynaden, Mark D Carr

J Biol Chem· June 2023

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Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80.
Tara Kang-Pettinger, Kayleigh Walker, Richard Brown, Richard Cowan, Helena Wright, Mark D Carr

J Biol Chem· January 2023

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Sequence-specific H, C and N backbone NMR assignments for the N-terminal IgV-like domain (D1) and full extracellular region (D1D2) of PD-L1.
Kayleigh Walker, Lorna C Waters, Geoff Kelly, Frederick W Muskett, Mark D Carr

Biomol NMR Assign· October 2022

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Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer's disease.
Preeti Bakrania, Gareth Hall, Yvonne Bouter, Caroline Bouter, Nicola Beindorff, Mark D Carr

Mol Psychiatry· February 2022

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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mark Austin, Daniel Burschowsky, Denice T Y Chan, Lesley Jenkinson, Stuart Haynes, Mark D Carr

MAbs· July 2021

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Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
Georgia Bullen, Jacob D Galson, Gareth Hall, Pedro Villar, Lien Moreels, Mark D Carr

Front Immunol· July 2021

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Conformational dynamics in interleukin 17A and 17F functional complexes is a key determinant of receptor A affinity and specificity.
Lorna C Waters, Vaclav Veverka, Sarah L Strong, Frederick W Muskett, Neesha Dedi, Mark D Carr

Cytokine· June 2021

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Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Denice T Y Chan, Lesley Jenkinson, Stuart W Haynes, Mark Austin, Agata Diamandakis, Mark D Carr

Proc Natl Acad Sci U S A· July 2020

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Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain.
Rebekka Schairer, Gareth Hall, Ming Zhang, Richard Cowan, Roberta Baravalle, Mark D Carr

Proc Natl Acad Sci U S A· February 2020

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Assessment of Putative PD-1/PD-L1 Inhibitors: Suggestions of an Alternative Mode of Action.
Derek J Blevins, Ronan Hanley, Trevor Bolduc, David A Powell, Michael Gignac, Mark D Carr

ACS Med Chem Lett· August 2019

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Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
Saleha Patel, Alice M Barkell, Deepti Gupta, Sarah L Strong, Shaun Bruton, Mark D Carr

J Biol Chem· August 2018

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Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Mark D Carr

PLoS Biol· May 2018

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Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.
Gareth Hall, Eilish Cullen, Kovilen Sawmynaden, Joanne Arnold, Simon Fox, Mark D Carr

J Biol Chem· August 2016

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Resonance assignment and secondary structure determination of full length human Dickkopf 4 (hDkk4), a secreted, disulphide-rich Wnt inhibitor protein.
Alice M Barkell, Gill Holdsworth, Lorna C Waters, Vaclav Veverka, Patrick M Slocombe, Mark D Carr

Biomol NMR Assign· April 2015

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¹⁵N, ¹³C and ¹H resonance assignments and secondary structure determination of a variable heavy domain of a heavy chain antibody.
Christine E Prosser, Lorna C Waters, Frederick W Muskett, Vaclav Veverka, Philip W Addis, Mark D Carr

Biomol NMR Assign· April 2014

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Conformational heterogeneity in antibody-protein antigen recognition: implications for high affinity protein complex formation.
Philip W Addis, Catherine J Hall, Shaun Bruton, Vaclav Veverka, Ian C Wilkinson, Bruce Carrington, Mark D Carr

J Biol Chem· March 2014

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Interaction of the transactivation domain of B-Myb with the TAZ2 domain of the coactivator p300: molecular features and properties of the complex.
Ojore Oka, Lorna C Waters, Sarah L Strong, Nuvjeevan S Dosanjh, Vaclav Veverka, Mark D Carr

PLoS One· June 2013

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Corrigendum to "The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation" [J. Mol. Biol. 425 (2013), 577-593].
Daniel Lightwood, Victoria O'Dowd, Bruce Carrington, Vaclav Veverka, Mark D Carr

J Mol Biol· June 2013

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Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
Alessio Bortoluzzi, Frederick W Muskett, Lorna C Waters, Philip W Addis, Barbara Rieck, Mark D Carr

J Biol Chem· May 2013

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Structure and interactions of the human programmed cell death 1 receptor.
Xiaoxiao Cheng, Vaclav Veverka, Anand Radhakrishnan, Lorna C Waters, Frederick W Muskett, Mark D Carr

J Biol Chem· April 2013

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The discovery, engineering and characterisation of a highly potent anti-human IL-13 fab fragment designed for administration by inhalation.
Daniel Lightwood, Victoria O'Dowd, Bruce Carrington, Vaclav Veverka, Mark D Carr

J Mol Biol· February 2013

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Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
Vaclav Veverka, Terry Baker, Nicholas T Redpath, Bruce Carrington, Frederick W Muskett, Mark D Carr

J Biol Chem· November 2012

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Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.
Gill Holdsworth, Patrick Slocombe, Carl Doyle, Bernadette Sweeney, Vaclav Veverka, Mark D Carr

J Biol Chem· August 2012

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