Publications by authors named "Alessio Bortoluzzi"

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Pushing the limits of hydrogen/deuterium exchange mass spectrometry to study protein:fragment low affinity interactions.
Catarina F Malta, Diana O Silva, Ulrich Grädler, Pedro M F Sousa, Djordje Musil, Alessio Bortoluzzi

Commun Chem· December 2025

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MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.
Timo Heinrich, Daniel Schwarz, Carl Petersson, Jakub Gunera, Sakshi Garg, Alessio Bortoluzzi

J Med Chem· March 2025

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Aldehyde Dehydrogenase 2 (ALDH2): A novel sorafenib target in hepatocellular carcinoma unraveled by the proteome-wide cellular thermal shift assay.
Inês C Ferreira, Estefania Torrejón, Bernardo Abecasis, Bruno M Alexandre, Ricardo A Gomes, Alessio Bortoluzzi

SLAS Discov· April 2024

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Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
Anastasia Amato, Xavier Lucas, Alessio Bortoluzzi, David Wright, Alessio Ciulli

ACS Chem Biol· April 2018

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Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.
Francesca E Morreale, Andrea Testa, Viduth K Chaugule, Alessio Bortoluzzi, Alessio Ciulli

J Med Chem· October 2017

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Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.
Alessio Bortoluzzi, Anastasia Amato, Xavier Lucas, Manuel Blank, Alessio Ciulli

Biochem J· May 2017

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Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
Francesca E Morreale, Alessio Bortoluzzi, Viduth K Chaugule, Connor Arkinson, Helen Walden

J Med Chem· May 2017

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Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
Alessio Bortoluzzi, Frederick W Muskett, Lorna C Waters, Philip W Addis, Barbara Rieck

J Biol Chem· May 2013

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The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action.
Franca Rossi, Jasbeer Singh Khanduja, Alessio Bortoluzzi, Joanna Houghton, Peter Sander

Nucleic Acids Res· September 2011

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Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex.
Diego Cotella, Susanne Radicke, Alessio Bortoluzzi, Ursula Ravens, Erich Wettwer

Pflugers Arch· June 2010

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