Publications by authors named "Geoffrey Dow"

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A Planned Trial to Evaluate the Safety and Efficacy of Tafenoquine + Atovaquone/Azithromycin in Hospitalized Patients With Babesiosis.
Geoffrey S Dow, Bryan Smith

J Infect Dis· July 2024

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Long-term safety of the tafenoquine antimalarial chemoprophylaxis regimen: A 12-month, randomized, double-blind, placebo-controlled trial.
Anne Novitt-Moreno, Adam Martidis, Victor Gonzalez, Janet Ransom, Charles B Scott, Geoffrey Dow

Travel Med Infect Dis· March 2022

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Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines.
Jonathan Berman, Tracey Brown, Geoffrey Dow, Stephen Toovey

Malar J· November 2018

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Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions.
Jessica L Smith, Kayla Sheridan, Christopher J Parkins, Lisa Frueh, Adriana L Jemison, Geoffrey Dow

Antiviral Res· July 2018

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Tafenoquine for malaria prophylaxis in adults: An integrated safety analysis.
Anne Novitt-Moreno, Janet Ransom, Geoffrey Dow, Bryan Smith, Lisa Thomas Read

Travel Med Infect Dis· October 2017

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Tafenoquine is not neurotoxic following supertherapeutic dosing in rats.
Geoffrey S Dow, Tracey Brown, Mark Reid, Bryan Smith, Stephen Toovey

Travel Med Infect Dis· October 2017

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The blood schizonticidal activity of tafenoquine makes an essential contribution to its prophylactic efficacy in nonimmune subjects at the intended dose (200 mg).
Geoffrey Dow, Bryan Smith

Malar J· May 2017

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Optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2: The search for a window for potential therapeutic efficacy.
Satoru Watanabe, Kitti Wing-Ki Chan, Geoffrey Dow, Eng Eong Ooi, Jenny G Low

Antiviral Res· March 2016

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Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.
Nicanor Obaldía, Geoffrey S Dow, Lucia Gerena, Dennis Kyle, William Otero

Sci Rep· February 2016

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Summary of anti-malarial prophylactic efficacy of tafenoquine from three placebo-controlled studies of residents of malaria-endemic countries.
Geoffrey S Dow, Jun Liu, Gina Lin, Brian Hetzell, Sarah Thieling

Malar J· November 2015

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The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models.
Jason C Sousa, Erin Milner, Dustin Carroll, William McCalmont, Sean Gardner, Geoffrey Dow

Eur J Drug Metab Pharmacokinet· December 2014

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A retrospective analysis of the protective efficacy of tafenoquine and mefloquine as prophylactic anti-malarials in non-immune individuals during deployment to a malaria-endemic area.
Geoffrey S Dow, William F McCarthy, Mark Reid, Bryan Smith, Douglas Tang

Malar J· February 2014

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The maximum potential market for dengue drugs V 1.0.
Geoffrey Dow, Eric Mora

Antiviral Res· November 2012

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Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy.
Erin Milner, Jason Sousa, Brandon Pybus, Jennifer Auschwitz, Diana Caridha, Geoffrey S Dow

Eur J Drug Metab Pharmacokinet· March 2012

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Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum.
Erin Milner, Jason Sousa, Brandon Pybus, Victor Melendez, Sean Gardner, Geoffrey Dow

Eur J Drug Metab Pharmacokinet· September 2011

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Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum.
Erin Milner, Sean Gardner, Jay Moon, Kristina Grauer, Jennifer Auschwitz, Geoffrey Dow

J Med Chem· September 2011

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Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta).
Geoffrey S Dow, Montip Gettayacamin, Pranee Hansukjariya, Rawiwan Imerbsin, Srawuth Komcharoen

Malar J· July 2011

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Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice.
Geoffrey S Dow, Erin Milner, Ian Bathurst, Jayendra Bhonsle, Diana Caridha

Malar J· June 2011

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Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum.
Erin Milner, William McCalmont, Jayendra Bhonsle, Diana Caridha, Dustin Carroll, Geoffrey Dow

Bioorg Med Chem Lett· February 2010

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Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols.
Erin Milner, William McCalmont, Jayendra Bhonsle, Diana Caridha, Jose Cobar, Geoffrey Stuart Dow

Malar J· February 2010

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Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.
Peter Wipf, Tingting Mo, Steven J Geib, Diana Caridha, Geoffrey S Dow

Org Biomol Chem· October 2009

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Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors.
Geoffrey S Dow, Yufeng Chen, Katherine T Andrews, Diana Caridha, Lucia Gerena

Antimicrob Agents Chemother· October 2008

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Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki.
Geoffrey S Dow, Alan J Magill, Colin Ohrt

Ther Clin Risk Manag· August 2008

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A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.
Yufeng Chen, Miriam Lopez-Sanchez, Doris N Savoy, Daniel D Billadeau, Geoffrey S Dow

J Med Chem· June 2008

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Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro.
Geoffrey S Dow, Diana Caridha, Michelle Goldberg, Lesley Wolf, Michael L Koenig

Genomics· November 2005

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