Publications by authors named "Georg Winter"

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Inhibitors supercharge kinase turnover through native proteolytic circuits.
Natalie S Scholes, Martino Bertoni, Arnau Comajuncosa-Creus, Katharina Kladnik, Xuefei Guo, Georg E Winter

Nature· November 2025

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Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes.
Artem Kalinichenko, Jakob Huemer, Theresa Humer, Matthias Haimel, Michael Svaton, Georg Winter

Sci Immunol· October 2025

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High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity.
James B Shaum, Miquel Muñoz I Ordoño, Erica A Steen, Daniela V Wenge, Hakyung Cheong, Georg E Winter

bioRxiv· September 2025

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Opportunities in proximity modulation: Bridging academia and industry.
Ivan Dikic, Cristina Mayor-Ruiz, Georg E Winter, Kerstin Koch, Alessio Ciulli

Mol Cell· August 2025

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Targeted protein degradation for cancer therapy.
Matthias Hinterndorfer, Valentina A Spiteri, Alessio Ciulli, Georg E Winter

Nat Rev Cancer· July 2025

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Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation.
Nianzhe He, Laura Depta, Cecilia Rossetti, Lucie Caramelle, Marko Cigler, Georg E Winter

Nat Chem Biol· February 2025

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Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP.
Marko Cigler, Hana Imrichova, Fabian Frommelt, Lucie Caramelle, Laura Depta, Georg E Winter

Nat Chem Biol· February 2025

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Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3.
Elisabeth Hennes, Belén Lucas, Natalie S Scholes, Xiu-Fen Cheng, Daniel C Scott, Georg E Winter

bioRxiv· January 2025

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Degradome analysis to identify direct protein substrates of small-molecule degraders.
Marco Jochem, Anna Schrempf, Lina-Marie Wagner, Dmitri Segal, Jose Cisneros, Georg E Winter

Cell Chem Biol· January 2025

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Thoughts for the future.
Lona M Alkhalaf, Cheryl Arrowsmith, Emily P Balskus, Giovanna Bergamini, Rashna Bhandari, Georg Winter

Nat Chem Biol· January 2025

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Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera.
Adam G Bond, Miquel Muñoz I Ordoño, Celia M Bisbach, Conner Craigon, Nikolai Makukhin, Georg E Winter

J Am Chem Soc· December 2024

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Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs.
Georg E Winter

ACS Chem Biol· October 2024

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Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins.
Gary Tin, Marko Cigler, Matthias Hinterndorfer, Kevin D Dong, Hana Imrichova, Georg E Winter

Bioorg Med Chem Lett· July 2024

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Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.
Chrysanthi Kagiou, Jose A Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Georg E Winter

Nat Commun· June 2024

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Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells.
Fabian Offensperger, Gary Tin, Miquel Duran-Frigola, Elisa Hahn, Sarah Dobner, Georg E Winter

Science· April 2024

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Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.
Bárbara M G Barbosa, Aikaterini Sfyaki, Sergi Rafael, Ferran José-Duran, Joan Pous, Georg E Winter

Angew Chem Int Ed Engl· March 2024

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Targeted protein degradation via intramolecular bivalent glues.
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Georg E Winter

Nature· March 2024

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Design principles for cyclin K molecular glue degraders.
Zuzanna Kozicka, Dakota J Suchyta, Vivian Focht, Georg Kempf, Georg Petzold, Georg E Winter

Nat Chem Biol· January 2024

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Proximity-inducing pharmacology.
Georg E Winter, Cristina Mayor-Ruiz

Nat Chem Biol· January 2024

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Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling.
Amanda Ng, Fabian Offensperger, Jose A Cisneros, Natalie S Scholes, Monika Malik, Georg E Winter

ACS Chem Biol· December 2023

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Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype.
Gang Xue, Jianing Xie, Matthias Hinterndorfer, Marko Cigler, Lara Dötsch, Georg E Winter

Nat Commun· November 2023

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Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors.
Vojtech Dvorak, Andrea Casiraghi, Claire Colas, Anna Koren, Tatjana Tomek, Georg E Winter

Cell Chem Biol· August 2023

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Pharmacological perturbation of the phase-separating protein SMNDC1.
Lennart Enders, Marton Siklos, Jan Borggräfe, Stefan Gaussmann, Anna Koren, Georg E Winter

Nat Commun· August 2023

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Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence.
Miquel Duran-Frigola, Marko Cigler, Georg E Winter

J Am Chem Soc· February 2023

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E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance.
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Georg E Winter

J Am Chem Soc· January 2023

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