Publications by authors named "Gerd Bendas"

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Modulating Immune Responses: The Double-Edged Sword of Platelet CD40L.
Gerd Bendas, Martina Gobec, Martin Schlesinger

Semin Thromb Hemost· November 2025

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Increased efficacy of PARP inhibitors against cisplatin-sensitive and -resistant ovarian cancer cells mediated via ATR and ATM inhibition.
Philipp König, Leon Bade, Julia Maria Eichhorn, Helena Skalski, Jindrich Cinatl, Gerd Bendas

Cell Death Discov· October 2025

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Target Engagement Studies and Kinetic Live-Cell Degradation Assays Enable the Systematic Characterization of Histone Deacetylase 6 Degraders.
Maria Hanl, Felix Feller, Irina Honin, Kathrin Tan, Martina Miranda, Gerd Bendas

ACS Pharmacol Transl Sci· September 2025

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A Novel Series of Synthetic Heparin-Mimetics-Itaconic Acid-Containing Copolymers for Targeting Tumor Cell Coagulability and Metastasis.
Katrin Nekipelov, Abdullah Al Nahain, Sven Otto, Yongbin Xu, Jin-Ping Li, Gerd Bendas

Macromol Biosci· July 2025

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Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders.
Shiyang Zhai, Irina Honin, Linda Schäker-Hübner, Maria Hanl, Lukas Jacobi, Gerd Bendas

J Med Chem· July 2025

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Pyrazinyl-Substituted Aminoazoles as Covalent Inhibitors of Thrombin: Synthesis, Structure, and Anticoagulant Properties.
Lukas Imberg, Alena I Siutkina, Catharina Erbacher, Judith Schmidt, Darius F Broekmans, Gerd Bendas

ACS Pharmacol Transl Sci· January 2025

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SLFN11 and ATR as targets for overcoming cisplatin resistance in ovarian cancer cells.
Philipp König, Julia Maria Eichhorn, Eloy Suparman, Nico Bückreiß, Jindrich Cinatl, Gerd Bendas

Biochim Biophys Acta Mol Basis Dis· December 2024

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Epigenetic Targeting of Heparan Sulfate 3-- and 6--Sulfation in Breast Cancer Cells: Prospects for Attenuating Prothrombotic Tumor Cell Activities.
Nico Bückreiß, Marie Schulz-Fincke, Philipp König, Marco Maccarana, Toin H van Kuppevelt, Gerd Bendas

ACS Pharmacol Transl Sci· August 2024

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Diversity Oriented Synthesis of Novel Xanthones Reveal Potent Doxorubicin-Inspired Analogs.
Jonas W Meringdal, Leon Bade, Gerd Bendas, Dirk Menche

ChemMedChem· May 2024

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The Role of CD36/GPIV in Platelet Biology.
Gerd Bendas, Martin Schlesinger

Semin Thromb Hemost· March 2024

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Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.
Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A Tararina, Emilia Neuwirt, Gerd Bendas

J Med Chem· November 2023

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Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer.
Vittoria Lopez, H J Maximilian Schuh, Salahuddin Mirza, Victoria J Vaaßen, Michael S Schmidt, Gerd Bendas

Front Immunol· September 2023

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A biscarbene gold(I)-NHC-complex overcomes cisplatin-resistance in A2780 and W1 ovarian cancer cells highlighting pERK as regulator of apoptosis.
Philipp König, Roman Zhulenko, Eloy Suparman, Henrik Hoffmeister, Nico Bückreiß, Gerd Bendas

Cancer Chemother Pharmacol· July 2023

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The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor.
Nourhan Hassan, Nico Bückreiß, Janes Efing, Marie Schulz-Fincke, Philipp König, Gerd Bendas

Cells· March 2023

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Exostosin 1 Knockdown Induces Chemoresistance in MV3 Melanoma Cells by Upregulating JNK and MEK/ERK Signaling.
Vladlena Pfeifer, Heiko Weber, Yuanyuan Wang, Martin Schlesinger, Christian Gorzelanny, Gerd Bendas

Int J Mol Sci· March 2023

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The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans.
Nourhan Hassan, Janes Efing, Ludwig Kiesel, Gerd Bendas, Martin Götte

Cancers (Basel)· February 2023

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Tumour cell-activated platelets modulate the immunological activity of CD4, CD8, and NK cells, which is efficiently antagonized by heparin.
Lukas M Gockel, Katrin Nekipelov, Vito Ferro, Gerd Bendas, Martin Schlesinger

Cancer Immunol Immunother· October 2022

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Development of the first non-hydroxamate selective HDAC6 degraders.
Tim Keuler, Beate König, Nico Bückreiß, Fabian B Kraft, Philipp König, Gerd Bendas

Chem Commun (Camb)· October 2022

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Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis.
Yuanyuan Wang, Xiaobo Liu, Tobias Obser, Alexander T Bauer, Martin Heyes, Gerd Bendas

Matrix Biol· August 2022

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Pentosan Polysulfate-A "Better Heparin" as Potential Medication for the Treatment of SARS-CoV-2 Infections?
Gerd Bendas

Thromb Haemost· June 2022

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Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors.
Linda Schäker-Hübner, Reza Haschemi, Thomas Büch, Fabian B Kraft, Birke Brumme, Gerd Bendas

ChemMedChem· May 2022

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Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models.
Lukas M Gockel, Vladlena Pfeifer, Fabian Baltes, Rafael D Bachmaier, Karl G Wagner, Gerd Bendas

Arch Pharm (Weinheim)· May 2022

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The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis.
Gerd Bendas, Martin Schlesinger

Exp Hematol Oncol· April 2022

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Insulin-like Growth Factor Binding Protein-2 (IGFBP2) Is a Key Molecule in the MACC1-Mediated Platelet Communication and Metastasis of Colorectal Cancer Cells.
Reza Haschemi, Dennis Kobelt, Elisabeth Steinwarz, Martin Schlesinger, Ulrike Stein, Gerd Bendas

Int J Mol Sci· November 2021

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Another structural correction for 1-oxo-1H-phenalene-2,3-dicarbonitriles: Synthesis of a potent BCL-2 inhibiting 7-phenoxy derivative.
Izidor Sosič, Martina Gobec, Christian Steinebach, Martin Schlesinger, Gerd Bendas

Arch Pharm (Weinheim)· October 2021

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