Publications by authors named "Gerd Mikus"

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Model-informed identification of optimised dosing strategies for meropenem in critically ill patients receiving SLEDD: an observational study.
Franz Weber, Christina Scharf, Linda B S Aulin, Ferdinand Weinelt, Michael Paal, Gerd Mikus

Infection· October 2025

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In vitro and in silico evaluation of the interaction of yohimbine with drug transporters and cytochrome P450 isoenzymes.
Gzona Bajraktari-Sylejmani, Rajamanikkam Kamaraj, Petr Pavek, Jürgen Burhenne, Gerd Mikus

Eur J Pharmacol· September 2025

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Author's Reply to Helsby and Hannam: 'Understanding Voriconazole Metabolism: A Middle-Out Physiologically-Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights'.
Ayatallah Saleh, Josefine Schulz, Jan-Frederik Schlender, Linda B S Aulin, Amrei-Pauline Konrad, Gerd Mikus

Clin Pharmacokinet· September 2025

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Breaking barriers: The novel in vitro microdialysis system enables reproducing in vivo extraction efficiencies of linezolid.
Felix Leon Müller, Davide Bindellini, Gerd Mikus, Robin Michelet, Charlotte Kloft

Eur J Pharm Sci· June 2025

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Influence of a Short Course of Ritonavir Used as Booster in Antiviral Therapies Against SARS-CoV-2 on the Exposure of Atorvastatin and Rosuvastatin.
Evelyn Krohmer, Brit Silja Rohr, Felicitas Stoll, Katja S Gümüs, Mariano Bergamino, Gerd Mikus

Cardiovasc Drugs Ther· April 2025

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Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers.
Alexander Lenard, Simon A Hermann, Felicitas Stoll, Juergen Burhenne, Kathrin I Foerster, Gerd Mikus

Front Pharmacol· April 2025

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ChatGPT does make up scientific references: should it be currently renamed CheatGPT?
Gerd Mikus

Eur J Clin Pharmacol· December 2024

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Understanding Voriconazole Metabolism: A Middle-Out Physiologically-Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights.
Ayatallah Saleh, Josefine Schulz, Jan-Frederik Schlender, Linda B S Aulin, Amrei-Pauline Konrad, Gerd Mikus

Clin Pharmacokinet· November 2024

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Nonlinear Mixed-Effects Model of Z-Endoxifen Concentrations in Tamoxifen-Treated Patients from the CEPAM Cohort.
Anna M Mc Laughlin, Thomas Helland, Fenja Klima, Stijn L W Koolen, Ron H N van Schaik, Gerd Mikus

Clin Pharmacol Ther· September 2024

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Effect of Clarithromycin, a Strong CYP3A and P-glycoprotein Inhibitor, on the Pharmacokinetics of Edoxaban in Healthy Volunteers and the Evaluation of the Drug Interaction with Other Oral Factor Xa Inhibitors by a Microdose Cocktail Approach.
Alexander Lenard, Simon A Hermann, Felicitas Stoll, Juergen Burhenne, Kathrin I Foerster, Gerd Mikus

Cardiovasc Drugs Ther· August 2024

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Dose-dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin.
Nicolas Hohmann, Anna S Friedrichs, Jürgen Burhenne, Antje Blank, Gerd Mikus

Clin Transl Sci· August 2024

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Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers.
Brit S Rohr, Evelyn Krohmer, Kathrin I Foerster, Jürgen Burhenne, Martin Schulz, Gerd Mikus

Clin Pharmacokinet· April 2024

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Evaluation of Hydroxychloroquine as a Perpetrator on Cytochrome P450 (CYP) 3A and CYP2D6 Activity with Microdosed Probe Drugs in Healthy Volunteers.
Felicitas Stoll, Antje Blank, Gerd Mikus, David Czock, Johanna Weiss

Eur J Drug Metab Pharmacokinet· January 2024

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Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data.
Franziska Kluwe, Robin Michelet, Wilhelm Huisinga, Markus Zeitlinger, Gerd Mikus

Clin Pharmacokinet· October 2023

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CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults.
Amin Muhareb, Antje Blank, Andreas D Meid, Kathrin I Foerster, Felicitas Stoll, Gerd Mikus

Clin Pharmacokinet· September 2023

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Time course of CYP3A activity during and after metamizole (dipyrone) in healthy volunteers.
Mareile H Breithaupt, Evelyn Krohmer, Lenka Taylor, Eva Körner, Torsten Hoppe-Tichy, Gerd Mikus

Br J Clin Pharmacol· August 2023

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Framework for Implementing Individualised Dosing of Anti-Cancer Drugs in Routine Care: Overcoming the Logistical Challenges.
Jason van Leuven, Simon Evans, Ganessan Kichenadasse, Neeltje Steeghs, Billie Bonevski, Gerd Mikus

Cancers (Basel)· June 2023

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Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers.
Vanessa Zhu, Jürgen Burhenne, Johanna Weiss, Mathias Haag, Ute Hofmann, Gerd Mikus

Front Pharmacol· April 2023

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Vericiguat: A Randomized, Phase Ib, Placebo-Controlled, Double-Blind, QTc Interval Study in Patients with Chronic Coronary Syndromes.
Michael Böttcher, Hans-Dirk Düngen, Vasile Corcea, Frank Donath, Rainard Fuhr, Gerd Mikus

Am J Cardiovasc Drugs· March 2023

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Frailty as a Marker for the Plasma Concentrations of Direct Oral Anticoagulants in Older Patients: Results of an Exploratory Study.
Annette Eidam, Julian Marji, Petra Benzinger, Kathrin I Foerster, Jürgen Burhenne, Gerd Mikus

Drugs Aging· February 2023

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Pharmacokinetics of a microdosed cocktail of three direct oral anticoagulants in children with congenital heart defects: study protocol for a single-centre clinical trial (DOAC-Child).
Simon A Hermann, Gerd Mikus, Kristine Chobanyan-Jürgens, Matthias Gorenflo, Victoria C Ziesenitz

BMJ Paediatr Open· January 2023

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Oral bioavailability of microdoses and therapeutic doses of midazolam as a 2-dimensionally printed orodispersible film in healthy volunteers.
Mareile H Breithaupt, Evelyn Krohmer, Lenka Taylor, Eva Koerner, Torsten Hoppe-Tichy, Gerd Mikus

Eur J Clin Pharmacol· December 2022

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Microdialysis of Voriconazole and its N-Oxide Metabolite: Amalgamating Knowledge of Distribution and Metabolism Processes in Humans.
Josefine Schulz, Robin Michelet, Markus Zeitlinger, Gerd Mikus, Charlotte Kloft

Pharm Res· December 2022

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Microdialysis of Drug and Drug Metabolite: a Comprehensive In Vitro Analysis for Voriconazole and Voriconazole N-oxide.
Josefine Schulz, Robin Michelet, Markus Zeitlinger, Gerd Mikus, Charlotte Kloft

Pharm Res· November 2022

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Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion.
Yomna M Nassar, Nicolas Hohmann, Robin Michelet, Katharina Gottwalt, Andreas D Meid, Gerd Mikus

Clin Pharmacokinet· November 2022

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