Publications by authors named "Gina Lu"

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Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.
Lawrence Kazak, Janane F Rahbani, Bozena Samborska, Gina Z Lu, Mark P Jedrychowski

Nat Metab· January 2021

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Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
Mark P Jedrychowski, Gina Z Lu, John Szpyt, Marco Mariotti, Ryan Garrity

Proc Natl Acad Sci U S A· May 2020

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Accumulation of succinate controls activation of adipose tissue thermogenesis.
Evanna L Mills, Kerry A Pierce, Mark P Jedrychowski, Ryan Garrity, Sally Winther, Gina Z Lu

Nature· August 2018

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Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Lawrence Kazak, Edward T Chouchani, Gina Z Lu, Mark P Jedrychowski, Curtis J Bare

Cell Metab· October 2017

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Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Lawrence Kazak, Edward T Chouchani, Gina Z Lu, Mark P Jedrychowski, Curtis J Bare

Cell Metab· October 2017

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UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.
Lawrence Kazak, Edward T Chouchani, Irina G Stavrovskaya, Gina Z Lu, Mark P Jedrychowski

Proc Natl Acad Sci U S A· July 2017

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Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.
Edward T Chouchani, Lawrence Kazak, Mark P Jedrychowski, Gina Z Lu, Brian K Erickson

Nature· August 2016

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Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.
Edward T Chouchani, Lawrence Kazak, Mark P Jedrychowski, Gina Z Lu, Brian K Erickson

Nature· April 2016

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A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.
Lawrence Kazak, Edward T Chouchani, Mark P Jedrychowski, Brian K Erickson, Kosaku Shinoda, Gina Z Lu

Cell· October 2015

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Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
Jeffrey A Pfefferkorn, John Litchfield, Richard Hutchings, Xue-Min Cheng, Scott D Larsen, Gina Lu

Bioorg Med Chem Lett· May 2011

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The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.
Xiao Zhen Zhou, Pengyu Huang, Rong Shi, Tae Ho Lee, Gina Lu, Kun Ping Lu

J Clin Invest· April 2011

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P2Y1 receptor antagonists as novel antithrombotic agents.
Jeffrey A Pfefferkorn, Chulho Choi, Thomas Winters, Robert Kennedy, Liguo Chi, Gina Lu

Bioorg Med Chem Lett· June 2008

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Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
William K C Park, Robert M Kennedy, Scott D Larsen, Steve Miller, Bruce D Roth, Gina H Lu

Bioorg Med Chem Lett· February 2008

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Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
Jeffrey A Pfefferkorn, Chulho Choi, Scott D Larsen, Bruce Auerbach, Richard Hutchings, Gina H Lu

J Med Chem· January 2008

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Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.
Scott D Larsen, Toni-Jo Poel, Kevin J Filipski, Jeffrey T Kohrt, Jeffrey A Pfefferkorn, Gina H Lu

Bioorg Med Chem Lett· October 2007

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Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.
Larry D Bratton, Bruce Auerbach, Chulho Choi, Lisa Dillon, Jeffrey C Hanselman, Gina Lu

Bioorg Med Chem· August 2007

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Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Jeffrey A Pfefferkorn, Chulho Choi, Yuntao Song, Bharat K Trivedi, Scott D Larsen, Gina Lu

Bioorg Med Chem Lett· August 2007

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Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Jeffrey A Pfefferkorn, Yuntao Song, Kuai-Lin Sun, Steven R Miller, Bharat K Trivedi, Gina Lu

Bioorg Med Chem Lett· August 2007

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Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.
Larry D Bratton, Gary F Filzen, Andrew Geyer, Jennifer K Hoffman, Gina Lu

Bioorg Med Chem Lett· July 2007

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Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Gary F Filzen, Larry Bratton, Xue-Min Cheng, Noe Erasga, Andrew Geyer, Gina Lu

Bioorg Med Chem Lett· July 2007

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