Publications by authors named "Ginger Wu"

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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT Receptor Agonists.
Joseph Carpenter, Ying Wang, Gang Wu, Jianxin Feng, Xiang-Yang Ye, Ginger Wu

J Med Chem· July 2017

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Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
Timothy B Durham, James L Toth, Valentine J Klimkowski, Julia X C Cao, Angela M Siesky, Ginger Y Wu

J Biol Chem· August 2015

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Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119.
Dean A Wacker, Ying Wang, Matthias Broekema, Karen Rossi, Steven O'Connor, Ginger Wu, Chunyu K Wu

J Med Chem· September 2014

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Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.
Guohua Zhao, Chet Kwon, Sharon N Bisaha, Philip D Stein, Karen A Rossi, Ginger Wu

Bioorg Med Chem Lett· July 2013

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Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.
John M Fevig, Jianxin Feng, Karen A Rossi, Keith J Miller, Ginger Wu

Bioorg Med Chem Lett· January 2013

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Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.
Saleem Ahmad, Khehyong Ngu, Keith J Miller, Ginger Wu, Chen-pin Hung

Bioorg Med Chem Lett· February 2010

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Position 5.46 of the serotonin 5-HT2A receptor contributes to a species-dependent variation for the 5-HT2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation.
Keith J Miller, Ginger Y Wu, Jeffrey G Varnes, Paul Levesque, Julia Li

Mol Pharmacol· December 2009

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Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
Dean A Wacker, Jeffrey G Varnes, Sarah E Malmstrom, Xueying Cao, Chen-Pin Hung, Ginger Wu

J Med Chem· March 2007

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