Publications by authors named "Giuseppe Saccomanni"

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New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2.
Rebecca Ferrisi, Beatrice Polini, Caterina Ricardi, Francesca Gado, Kawthar A Mohamed, Giuseppe Saccomanni

Int J Mol Sci· January 2023

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Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CBR).
Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A Mohamed, Giuseppe Saccomanni

Front Chem· September 2022

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Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
Francesca Gado, Rebecca Ferrisi, Beatrice Polini, Kawthar A Mohamed, Caterina Ricardi, Giuseppe Saccomanni

J Med Chem· July 2022

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Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells.
Francesca Gado, Rebecca Ferrisi, Sarah Di Somma, Fabiana Napolitano, Kawthar A Mohamed, Giuseppe Saccomanni

Molecules· May 2022

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Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids.
Andrea Bacci, Francesca Corsi, Massimiliano Runfola, Simona Sestito, Ilaria Piano, Giuseppe Saccomanni

Pharmaceuticals (Basel)· May 2022

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Tyrosol-Enriched Tomatoes by Diffusion across the Fruit Peel from a Chitosan Coating: A Proposal of Functional Food.
Silvia Tampucci, Antonella Castagna, Daniela Monti, Clementina Manera, Giuseppe Saccomanni

Foods· February 2021

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Design and synthesis of HS-donor hybrids: A new treatment for Alzheimer's disease?
Simona Sestito, Letizia Pruccoli, Massimiliano Runfola, Valentina Citi, Alma Martelli, Giuseppe Saccomanni

Eur J Med Chem· December 2019

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Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer.
Beatrice Polini, Maria Digiacomo, Sara Carpi, Simone Bertini, Francesca Gado, Giuseppe Saccomanni

Toxicol In Vitro· October 2018

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Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells.
Antonella Capozzi, Vincenzo Mattei, Stefano Martellucci, Valeria Manganelli, Giuseppe Saccomanni

Int J Mol Sci· July 2018

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Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.
Simone Bertini, Andrea Chicca, Francesca Gado, Chiara Arena, Daniela Nieri, Giuseppe Saccomanni

Bioorg Med Chem· December 2017

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Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors.
Simone Bertini, Elisa Ghilardi, Valentina Asso, Filippo Minutolo, Simona Rapposelli, Giuseppe Saccomanni

Bioorg Med Chem Lett· November 2017

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Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors.
Simone Bertini, Giuseppe Saccomanni, Sara Del Carlo, Maria Digiacomo, Claudia Gargini

Molecules· July 2017

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Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
Carlotta Granchi, Flavio Rizzolio, Stefano Palazzolo, Sara Carmignani, Marco Macchia, Giuseppe Saccomanni

J Med Chem· November 2016

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Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells.
Stefano Fogli, Chiara Arena, Sara Carpi, Beatrice Polini, Simone Bertini, Giuseppe Saccomanni

Nutr Cancer· July 2016

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Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.
Simone Bertini, Andrea Chicca, Chiara Arena, Stefano Chicca, Giuseppe Saccomanni

Eur J Med Chem· June 2016

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New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.
Clementina Manera, Anna Maria Malfitano, Teija Parkkari, Valentina Lucchesi, Sara Carpi, Giuseppe Saccomanni

Eur J Med Chem· June 2015

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Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor.
Giuseppe Saccomanni, Giancarlo Pascali, Sara Del Carlo, Daniele Panetta, Mariarosaria De Simone

Bioorg Med Chem Lett· June 2015

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Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.
Simone Bertini, Teija Parkkari, Juha R Savinainen, Chiara Arena, Giuseppe Saccomanni

Eur J Med Chem· January 2015

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CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.
Valentina Lucchesi, Dow P Hurst, Derek M Shore, Simone Bertini, Brandie M Ehrmann, Giuseppe Saccomanni

J Med Chem· November 2014

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Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography.
Enrico Serni, Valeria Audino, Sara Del Carlo, Clementina Manera, Giuseppe Saccomanni

Nat Prod Res· July 2014

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1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.
Valentina Lucchesi, Teija Parkkari, Juha R Savinainen, Anna Maria Malfitano, Marco Allarà, Giuseppe Saccomanni

Eur J Med Chem· March 2014

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Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis.
Anna Maria Malfitano, Chiara Laezza, Alba D'Alessandro, Claudio Procaccini, Giuseppe Saccomanni

PLoS One· February 2014

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Immune-modulation and properties of absorption and blood brain barrier permeability of 1,8-naphthyridine derivatives.
Anna Maria Malfitano, Chiara Laezza, Giuseppe Saccomanni, Tiziano Tuccinardi, Clementina Manera

J Neuroimmune Pharmacol· December 2013

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A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis.
Antonella Capozzi, Elisabetta Mantuano, Paola Matarrese, Giuseppe Saccomanni, Clementina Manera

Anticancer Agents Med Chem· July 2012

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Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.
Clementina Manera, Giuseppe Saccomanni, Anna Maria Malfitano, Simone Bertini, Francesca Castelli

Eur J Med Chem· June 2012

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