Publications by authors named "Graham T Dempsey"

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Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype.
James J Fink, Nathaniel Delaney-Busch, Ryan Dawes, Evanthia Nanou, Christopher Folts, Graham T Dempsey

Commun Biol· November 2024

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A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology.
Pin W Liu, Hongkang Zhang, Christopher A Werley, Monika Pichler, Steven J Ryan, Graham T Dempsey

Pain· April 2024

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Developing antisense oligonucleotides for a mutation-induced, ultra-rare neurological disorder using patient-derived cellular models.
Luis A Williams, David J Gerber, Amy Elder, Wei Chou Tseng, Valeriya Baru, Graham T Dempsey

Mol Ther Nucleic Acids· September 2022

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Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells.
Gabriel B Borja, Hongkang Zhang, Benjamin N Harwood, Jane Jacques, Jennifer Grooms, Graham T Dempsey

Front Mol Neurosci· July 2022

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'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies.
Dina Simkin, Christina Ambrosi, Kelly A Marshall, Luis A Williams, Jordyn Eisenberg, Graham T Dempsey

Trends Pharmacol Sci· May 2022

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Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls.
Dina Simkin, Vasileios Papakis, Bernabe I Bustos, Christina M Ambrosi, Steven J Ryan, Graham T Dempsey

Stem Cell Reports· April 2022

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Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.
Yalan Zhang, Imran H Quraishi, Heather McClure, Luis A Williams, YungChih Cheng, Graham T Dempsey

FASEB J· December 2021

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Probing Synaptic Signaling with Optogenetic Stimulation and Genetically Encoded Calcium Reporters.
Gabriel B Borja, Himali Shroff, Hansini Upadhyay, Pin W Liu, Valeriya Baru, Graham T Dempsey

Methods Mol Biol· March 2021

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Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of Na1.7 Inhibitors.
Hongkang Zhang, Bryan D Moyer, Violeta Yu, Joseph G McGivern, Michael Jarosh, Graham T Dempsey

SLAS Discov· June 2020

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Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms.
Emily R Pfeiffer-Kaushik, Godfrey L Smith, Beibei Cai, Graham T Dempsey, Maria P Hortigon-Vinagre

J Pharmacol Toxicol Methods· July 2019

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Inhale, exhale: Probing the inside-out mechanism of nicotine addiction using novel fluorescent sensors.
Owen B McManus, Christopher A Werley, Graham T Dempsey

J Gen Physiol· June 2019

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Scalable Measurements of Intrinsic Excitability in Human iPS Cell-Derived Excitatory Neurons Using All-Optical Electrophysiology.
Luis A Williams, Vaibhav Joshi, Michael Murphy, John Ferrante, Christopher A Werley, Graham T Dempsey

Neurochem Res· March 2019

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All-Optical Electrophysiology for Disease Modeling and Pharmacological Characterization of Neurons.
Christopher A Werley, Ted Brookings, Hansini Upadhyay, Luis A Williams, Owen B McManus, Graham T Dempsey

Curr Protoc Pharmacol· September 2017

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Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging.
Graham T Dempsey, Khuram W Chaudhary, Nicholas Atwater, Cuong Nguyen, Barry S Brown

J Pharmacol Toxicol Methods· May 2017

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Targeting neuronal function for CNS drug discovery.
Chris M Hempel, Christopher A Werley, Graham T Dempsey, David J Gerber

Drug Discov Today Technol· March 2017

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Characterization and development of photoactivatable fluorescent proteins for single-molecule-based superresolution imaging.
Siyuan Wang, Jeffrey R Moffitt, Graham T Dempsey, X Sunney Xie, Xiaowei Zhuang

Proc Natl Acad Sci U S A· June 2014

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A user's guide to localization-based super-resolution fluorescence imaging.
Graham T Dempsey

Methods Cell Biol· February 2014

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Phosphine quenching of cyanine dyes as a versatile tool for fluorescence microscopy.
Joshua C Vaughan, Graham T Dempsey, Eileen Sun, Xiaowei Zhuang

J Am Chem Soc· January 2013

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Molecular architecture and assembly principles of Vibrio cholerae biofilms.
Veysel Berk, Jiunn C N Fong, Graham T Dempsey, Omer N Develioglu, Xiaowei Zhuang

Science· July 2012

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Multicolor super-resolution fluorescence imaging via multi-parameter fluorophore detection.
Mark Bates, Graham T Dempsey, Kok Hao Chen, Xiaowei Zhuang

Chemphyschem· January 2012

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Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging.
Graham T Dempsey, Joshua C Vaughan, Kok Hao Chen, Mark Bates, Xiaowei Zhuang

Nat Methods· November 2011

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Photoswitching mechanism of cyanine dyes.
Graham T Dempsey, Mark Bates, Walter E Kowtoniuk, David R Liu, Roger Y Tsien

J Am Chem Soc· December 2009

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Fast in vitro translation system immobilized on a surface via specific biotinylation of the ribosome.
Romualdas Stapulionis, Yuhong Wang, Graham T Dempsey, Rama Khudaravalli, Karen Margrethe Nielsen

Biol Chem· September 2008

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Multicolor super-resolution imaging with photo-switchable fluorescent probes.
Mark Bates, Bo Huang, Graham T Dempsey, Xiaowei Zhuang

Science· September 2007

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Single-molecule structural dynamics of EF-G--ribosome interaction during translocation.
Yuhong Wang, Haiou Qin, Rama D Kudaravalli, Stanislas V Kirillov, Graham T Dempsey

Biochemistry· September 2007

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