Publications by authors named "Grant Walkup"

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Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence.
Preeti Sule, Ronak Tilvawala, Toriq Mustapha, Hany Hassounah, Aneesa Noormohamed, Grant K Walkup

J Clin Microbiol· December 2019

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New directions using reporter enzyme fluorescence (REF) as a tuberculosis diagnostic platform.
Preeti Sule, Ronak Tilvawala, Parnia Behinaein, Grant K Walkup, Jeffrey D Cirillo

Tuberculosis (Edinb)· December 2016

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Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC.
Sushmita D Lahiri, Grant K Walkup, James D Whiteaker, Tiffany Palmer, Kathy McCormack

J Antimicrob Chemother· February 2016

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Corrigendum: Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Gregory S Basarab, Gunther H Kern, John McNulty, John P Mueller, Kenneth Lawrence, Grant Walkup

Sci Rep· September 2015

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ESKAPEing the labyrinth of antibacterial discovery.
Ruben Tommasi, Dean G Brown, Grant K Walkup, John I Manchester, Alita A Miller

Nat Rev Drug Discov· August 2015

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Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.
Gunther Kern, Tiffany Palmer, David E Ehmann, Adam B Shapiro, Beth Andrews, Grant K Walkup

J Biol Chem· August 2015

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Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Gregory S Basarab, Gunther H Kern, John McNulty, John P Mueller, Kenneth Lawrence, Grant Walkup

Sci Rep· July 2015

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Translating slow-binding inhibition kinetics into cellular and in vivo effects.
Grant K Walkup, Zhiping You, Philip L Ross, Eleanor K H Allen, Fereidoon Daryaee

Nat Chem Biol· June 2015

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Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection.
Mingyu Liu, Christina Blinn, Sarah M McLeod, John W Wiseman, Joseph V Newman, Grant K Walkup

PLoS One· February 2015

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Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
Boudewijn L M de Jonge, Grant K Walkup, Sushmita D Lahiri, Hoan Huynh, Georg Neckermann

Antimicrob Agents Chemother· December 2013

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Kinetics of avibactam inhibition against Class A, C, and D β-lactamases.
David E Ehmann, Haris Jahic, Philip L Ross, Rong-Fang Gu, Jun Hu, Grant K Walkup

J Biol Chem· September 2013

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Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.
David E Ehmann, Haris Jahić, Philip L Ross, Rong-Fang Gu, Jun Hu, Grant K Walkup

Proc Natl Acad Sci U S A· July 2012

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Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
Ann E Eakin, Oluyinka Green, Neil Hales, Grant K Walkup, Shanta Bist

Antimicrob Agents Chemother· March 2012

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Structure guided understanding of NAD+ recognition in bacterial DNA ligases.
Sushmita D Lahiri, Rong-Fang Gu, Ning Gao, Irene Karantzeni, Grant K Walkup

ACS Chem Biol· March 2012

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A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase.
Adam B Shapiro, Ann E Eakin, Grant K Walkup, Olga Rivin

J Biomol Screen· June 2011

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A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase.
Adam B Shapiro, Ning Gao, Jason Thresher, Grant K Walkup, James Whiteaker

J Biomol Screen· June 2011

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Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.
Scott D Mills, Ann E Eakin, Ed T Buurman, Joseph V Newman, Ning Gao, Grant K Walkup

Antimicrob Agents Chemother· March 2011

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Evaluation of pKa estimation methods on 211 druglike compounds.
John Manchester, Grant Walkup, Olga Rivin, Zhiping You

J Chem Inf Model· April 2010

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Correction for interference by test samples in high-throughput assays.
Adam B Shapiro, Grant K Walkup, Thomas A Keating

J Biomol Screen· September 2009

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New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications.
Stephen R Adams, Robert E Campbell, Larry A Gross, Brent R Martin, Grant K Walkup

J Am Chem Soc· May 2002

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