Publications by authors named "Greg Thurber"

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Combining antibody conjugates with cytotoxic and immune-stimulating payloads maximizes anti-cancer activity.
Tiexin Wang, Dong Jun Koo, Peter M Tessier, Greg M Thurber

Mol Oncol· January 2026

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Oral Administration of a Bivalent Carbonic Anhydrase IX Near-Infrared Imaging Agent Detects Hypoxic Tumors in a Mouse Model.
Haolong Huang, Matthew Proefke, Eshita Khera, Greg M Thurber

ACS Sens· January 2026

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Maximizing activity and selectivity of antibody-mediated effector functions using antibody mixtures.
Tiexin Wang, Alec A Desai, Greg M Thurber, Peter M Tessier

MAbs· December 2025

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Unveiling the molecular and immunological drivers of antibody-drug conjugates in cancer treatment.
Alfred Zippelius, Sara M Tolaney, Paolo Tarantino, Joseph P Balthasar, Greg M Thurber

Nat Rev Cancer· December 2025

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IKS04, a CanAg-Targeting Antibody-Drug Conjugate with Pyrrolobenzodiazepine, Shows Enhanced Efficacy with Unconjugated Antibody Coadministration in Animal Models.
Haolong Huang, Jutta Deckert, Justyna Mysliwy, Adam Lodge, Robert J Lutz, Greg M Thurber

Mol Cancer Ther· December 2025

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Impacts of Antibody Structure and Mixtures on Receptor Signaling for Antibody-Dependent Cellular Cytotoxicity.
Jiakun Guan, Tiexin Wang, Peter M Tessier, Greg M Thurber

AAPS J· December 2025

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In vivo Auto-tuning of Antibody-Drug Conjugate Delivery to Maximize Efficacy using High-Avidity, Low-Affinity Antibodies.
Anna Kopp, Shujun Dong, Hyeyoung Kwon, Tiexin Wang, Alec A Desai, Greg M Thurber

Mol Cancer Ther· December 2025

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Optimizing Solid Tumor Treatment with Antibody-drug Conjugates Using Agent-Based Modeling: Considering the Role of a Carrier Dose and Payload Class.
Melissa C Calopiz, Jennifer J Linderman, Greg M Thurber

Pharm Res· June 2024

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Design of Crosslinking Antibodies For T-Cell Activation: Experimental and Computational Analysis of PD-1/CD137 Bispecific Agents.
Anna Kopp, Jiakun Guan, Colette Johnston, Steven Vance, James Legg, Greg M Thurber

AAPS J· June 2024

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Clinical translation of antibody drug conjugate dosing in solid tumors from preclinical mouse data.
Baron Rubahamya, Shujun Dong, Greg M Thurber

Sci Adv· May 2024

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Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies.
Anna Kopp, Shujun Dong, Hyeyoung Kwon, Tiexin Wang, Alec A Desai, Greg M Thurber

bioRxiv· April 2024

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Improving Intracellular Delivery of an Antibody-Drug Conjugate Targeting Carcinoembryonic Antigen Increases Efficacy at Clinically Relevant Doses In Vivo.
Ian Nessler, Baron Rubahamya, Anna Kopp, Scott Hofsess, Thomas M Cardillo, Greg M Thurber

Mol Cancer Ther· March 2024

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Machine learning to predict continuous protein properties from binary cell sorting data and map unseen sequence space.
Marshall Case, Matthew Smith, Jordan Vinh, Greg Thurber

Proc Natl Acad Sci U S A· March 2024

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Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents.
Anna Kopp, Hyeyoung Kwon, Colette Johnston, Steven Vance, James Legg, Greg M Thurber

Neoplasia· February 2024

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Mechanistically Weighted Metric to Predict In Vivo Antibody-Receptor Occupancy: An Analytical Approach.
Eshita Khera, Jaeyeon Kim, Andrew Stein, Matt Ratanapanichkich, Greg M Thurber

J Pharmacol Exp Ther· October 2023

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Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display.
Marshall Case, Tejas Navaratna, Jordan Vinh, Greg Thurber

ACS Chem Biol· April 2023

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Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology.
Laureen de Bever, Sorraya Popal, Jord van Schaik, Baron Rubahamya, Floris L van Delft, Greg M Thurber

Bioconjug Chem· March 2023

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Antibody-Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release.
Anna Kopp, Scott Hofsess, Thomas M Cardillo, Serengulam V Govindan, Jennifer Donnell, Greg M Thurber

Mol Cancer Ther· January 2023

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Pharmacokinetics and Pharmacodynamics of TAK-164 Antibody Drug Conjugate Coadministered with Unconjugated Antibody.
Bruna Menezes, Eshita Khera, Melissa Calopiz, Michael D Smith, Michelle L Ganno, Greg M Thurber

AAPS J· October 2022

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Design of high avidity and low affinity antibodies for in situ control of antibody drug conjugate targeting.
Reginald Evans, Greg M Thurber

Sci Rep· May 2022

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Predictive Simulations in Preclinical Oncology to Guide the Translation of Biologics.
Shujun Dong, Ian Nessler, Anna Kopp, Baron Rubahamya, Greg M Thurber

Front Pharmacol· March 2022

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Cellular-Resolution Imaging of Bystander Payload Tissue Penetration from Antibody-Drug Conjugates.
Eshita Khera, Shujun Dong, Haolong Huang, Laureen de Bever, Floris L van Delft, Greg M Thurber

Mol Cancer Ther· February 2022

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Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2-Positive Tumors.
Bruna Menezes, Jennifer J Linderman, Greg M Thurber

Drug Metab Dispos· January 2022

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Key metrics to expanding the pipeline of successful antibody-drug conjugates.
Ian Nessler, Bruna Menezes, Greg M Thurber

Trends Pharmacol Sci· October 2021

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Reply: From Mice to Humans: The Exocrine Pancreas Does Not Matter in Human GLP-1 Receptor Imaging.
Greg M Thurber

J Nucl Med· May 2021

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