Publications by authors named "Haim Leader"

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The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.
Orly Dym, Nidhi Aggarwal, Yacov Ashani, Haim Leader, Shira Albeck

Acta Crystallogr D Struct Biol· November 2023

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Utilization of diverse organophosphorus pollutants by marine bacteria.
Dragana Despotović, Einav Aharon, Olena Trofimyuk, Artem Dubovetskyi, Kesava Phaneendra Cherukuri, Haim Leader

Proc Natl Acad Sci U S A· August 2022

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A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents.
Dragana Despotović, Einav Aharon, Artem Dubovetskyi, Haim Leader, Yacov Ashani

Protein Eng Des Sel· December 2019

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Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
Olga Khersonsky, Rosalie Lipsh, Ziv Avizemer, Yacov Ashani, Moshe Goldsmith, Haim Leader

Mol Cell· October 2018

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Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.
Moshe Goldsmith, Nidhi Aggarwal, Yacov Ashani, Halim Jubran, Per Jr Greisen, Haim Leader

Protein Eng Des Sel· April 2017

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Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.
Moshe Goldsmith, Simone Eckstein, Yacov Ashani, Per Greisen, Haim Leader

Arch Toxicol· November 2016

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In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.
Yacov Ashani, Haim Leader, Nidhi Aggarwal, Israel Silman, Franz Worek

Chem Biol Interact· November 2016

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Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study.
Franz Worek, Thomas Seeger, Georg Reiter, Moshe Goldsmith, Yacov Ashani, Haim Leader

Toxicol Lett· November 2014

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Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro.
Franz Worek, Thomas Seeger, Moshe Goldsmith, Yacov Ashani, Haim Leader

Arch Toxicol· June 2014

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Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries.
Izhack Cherny, Per Greisen, Yacov Ashani, Sagar D Khare, Gustav Oberdorfer, Haim Leader

ACS Chem Biol· November 2013

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Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.
Moshe Goldsmith, Yacov Ashani, Yair Simo, Moshe Ben-David, Haim Leader

Chem Biol· April 2012

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Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Sagar D Khare, Yakov Kipnis, Per Greisen, Ryo Takeuchi, Yacov Ashani, Haim Leader

Nat Chem Biol· February 2012

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In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.
Yacov Ashani, Moshe Goldsmith, Haim Leader, Israel Silman, Joel L Sussman

Toxicol Lett· September 2011

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Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.
Rinkoo D Gupta, Moshe Goldsmith, Yacov Ashani, Yair Simo, Gavriel Mullokandov, Haim Leader

Nat Chem Biol· February 2011

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Versatile scheme for the step-by-step assembly of nanoparticle multilayers.
Yulia Chaikin, Haim Leader, Ronit Popovitz-Biro, Alexander Vaskevich, Israel Rubinstein

Langmuir· February 2011

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Pro-2-PAM therapy for central and peripheral cholinesterases.
James C Demar, Edward D Clarkson, Ruthie H Ratcliffe, Amy J Campbell, Sonia G Thangavelu, Haim Leader

Chem Biol Interact· September 2010

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Rapid formation of coordination multilayers using accelerated self-assembly procedure (ASAP).
Miryam Greenstein, Rivka Ben Ishay, Ben M Maoz, Haim Leader, Alexander Vaskevich

Langmuir· May 2010

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Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase.
Chunyuan Luo, Haim Leader, Zoran Radic, Donald M Maxwell, Palmer Taylor

Biochem Pharmacol· August 2003

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Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.
Yacov Ashani, Apurba K Bhattacharjee, Haim Leader, Ashima Saxena, Bhupendra P Doctor

Biochem Pharmacol· July 2003

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Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.
Haim Leader, Alan David Wolfe, Peter K Chiang, Richard K Gordon

J Med Chem· February 2002

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