Publications by authors named "Israel Silman"

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Why is binding of a divalent metal cation to a structural motif containing four carboxylate residues not accompanied by a conformational change?
Sofya Lushchekina, Lev Weiner, Yacov Ashani, Reeki Emrizal, Mohd Firdaus-Raih, Israel Silman

Protein Sci· December 2024

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The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.
Orly Dym, Nidhi Aggarwal, Yacov Ashani, Haim Leader, Shira Albeck, Israel Silman

Acta Crystallogr D Struct Biol· November 2023

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Do "Newly Born" orphan proteins resemble "Never Born" proteins? A study using three deep learning algorithms.
Jing Liu, Rongqing Yuan, Wei Shao, Jitong Wang, Israel Silman

Proteins· August 2023

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Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.
Sarka Pokorna, Olga Khersonsky, Rosalie Lipsh-Sokolik, Adi Goldenzweig, Rebekka Nielsen, Israel Silman

FEBS J· July 2023

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Preface: Cholinergic mechanisms: This is the Preface for the special issue "Cholinergic Mechanisms".
Lili Anglister, Israel Silman, Hermona Soreq

J Neurochem· September 2021

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The multiple biological roles of the cholinesterases.
Israel Silman

Prog Biophys Mol Biol· July 2021

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Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Israel Silman, Valery L Shnyrov, Yacov Ashani, Esther Roth, Anne Nicolas

Protein Sci· May 2021

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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.
Elisabet Viayna, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Pedro Cisternas, Carolina A Oliva, Israel Silman

J Med Chem· January 2021

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Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function.
Joel L Sussman, Israel Silman

Neuropharmacology· November 2020

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Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor.
Marco Catto, Leonardo Pisani, Eugenio de la Mora, Benny Danilo Belviso, Giuseppe Felice Mangiatordi, Israel Silman

ACS Med Chem Lett· May 2020

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Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers.
Lilly Toker, Israel Silman, Tzviya Zeev-Ben-Mordehai, Joel L Sussman, Lawrence M Schopfer

Chem Biol Interact· March 2020

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A Second Look at the Crystal Structures of Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides.
Florian Nachon, Terrone L Rosenberry, Israel Silman, Joel L Sussman

Molecules· March 2020

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Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design.
Nellore Bhanu Chandar, Irena Efremenko, Israel Silman, Jan M L Martin, Joel L Sussman

Chem Biol Interact· September 2019

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The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.
Dana A Novichkova, Sofya V Lushchekina, Orly Dym, Patrick Masson, Israel Silman

Chem Biol Interact· August 2019

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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Killian Oukoloff, Nicolas Coquelle, Manuela Bartolini, Marina Naldi, Rémy Le Guevel, Israel Silman

Eur J Med Chem· April 2019

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Generation of Reactive Oxygen Species by Photosensitizers and their Modes of Action on Proteins.
Itzhak Bilkis, Israel Silman, Lev Weiner

Curr Med Chem· March 2019

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Novel multitarget-directed ligands targeting acetylcholinesterase and σ receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.
Julien Lalut, Gianluca Santoni, Delphine Karila, Cédric Lecoutey, Audrey Davis, Israel Silman

Eur J Med Chem· January 2019

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Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly.
Miguel Ricardo Leung, Laura S van Bezouwen, Lawrence M Schopfer, Joel L Sussman, Israel Silman

Proc Natl Acad Sci U S A· December 2018

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Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.
Gianluca Santoni, Julien de Sousa, Eugenio de la Mora, José Dias, Ludovic Jean, Israel Silman

J Med Chem· September 2018

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Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.
Tamara Zorbaz, Anissa Braïki, Nikola Maraković, Julien Renou, Eugenio de la Mora, Israel Silman

Chemistry· July 2018

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Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.
Adi Goldenzweig, Moshe Goldsmith, Shannon E Hill, Or Gertman, Paola Laurino, Israel Silman

Mol Cell· April 2018

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Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.
Carles Galdeano, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Manuela Bartolini, Belén Pérez, Israel Silman

Molecules· March 2018

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Alexander George Karczmar (1917-2017).
Hermona Soreq, Israel Silman

J Neurochem· December 2017

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Preface: Cholinergic Mechanisms.
Marco A M Prado, Pascale Marchot, Israel Silman

J Neurochem· August 2017

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Computational Studies on Acetylcholinesterases.
Yechun Xu, Shanmei Cheng, Joel L Sussman, Israel Silman, Hualiang Jiang

Molecules· August 2017

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