Publications by authors named "Per Greisen"

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Benchmarking inverse folding models for antibody CDR sequence design.
Yifan Li, Yuxiang Lang, Chenrui Xu, Yi Zhou, Ziwei Pang, Per Jr Greisen

PLoS One· June 2025

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Designed endocytosis-inducing proteins degrade targets and amplify signals.
Buwei Huang, Mohamad Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Per Jr Greisen

Nature· February 2025

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Structure-Based Computational Scanning of Chemical Modification Sites in Biologics.
Nidhin Thomas, Tanmoy Sanyal, Per Greisen, Kristine Deibler

ACS Omega· August 2024

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Computational design of N-linked glycans for high throughput epitope profiling.
Per Jr Greisen, Li Yi, Rong Zhou, Jian Zhou, Eva Johansson

Protein Sci· October 2023

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Designed Endocytosis-Triggering Proteins mediate Targeted Degradation.
Buwei Huang, Mohamad Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Per Greisen

bioRxiv· September 2023

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A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa.
Anders B Sorensen, Per Jr Greisen, Jesper J Madsen, Jacob Lund, Gorm Andersen

Sci Rep· March 2022

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Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica.
Yongshuo Ma, Nian Liu, Per Greisen, Jingbo Li, Kangjian Qiao

Nat Commun· January 2022

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A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Henrik Østergaard, Jacob Lund, Per J Greisen, Stine Kjellev, Anette Henriksen

Blood· October 2021

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Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering.
Kristin J Adolfsen, Isolde Callihan, Catherine E Monahan, Per Jr Greisen, James Spoonamore

Nat Commun· October 2021

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Enhanced chemoselectivity of a plant cytochrome P450 through protein engineering of surface and catalytic residues.
Xiaopeng Zhang, Wei Luo, Yinying Yao, Xuming Luo, Chao Han, Per Greisen

aBIOTECH· September 2021

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Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Parisa Hosseinzadeh, Paris R Watson, Timothy W Craven, Xinting Li, Stephen Rettie, Per Jr Greisen

Nat Commun· June 2021

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Optimizing selectivity of anion hydrophobic multimodal chromatography for purification of a single-chain variable fragment.
Laila I Sakhnini, Anja K Pedersen, Ileana Rodríguez León, Per J Greisen, Jens Jacob Hansen

Eng Life Sci· July 2019

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A structural and data-driven approach to engineering a plant cytochrome P450 enzyme.
Dawei Li, Yongshuo Ma, Yuan Zhou, Junbo Gou, Yang Zhong, Per Greisen

Sci China Life Sci· July 2019

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Improving the Developability of an Antigen Binding Fragment by Aspartate Substitutions.
Laila I Sakhnini, Per J Greisen, Charlotte Wiberg, Zoltan Bozoky, Søren Lund

Biochemistry· June 2019

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Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold.
Austin L Day, Per Greisen, Lindsey Doyle, Alberto Schena, Nephi Stella

Protein Eng Des Sel· October 2018

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Computational design of environmental sensors for the potent opioid fentanyl.
Matthew J Bick, Per J Greisen, Kevin J Morey, Mauricio S Antunes, David La

Elife· September 2017

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Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.
Moshe Goldsmith, Nidhi Aggarwal, Yacov Ashani, Halim Jubran, Per Jr Greisen

Protein Eng Des Sel· April 2017

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Simultaneous Optimization of Biomolecular Energy Functions on Features from Small Molecules and Macromolecules.
Hahnbeom Park, Philip Bradley, Per Greisen, Yuan Liu, Vikram Khipple Mulligan

J Chem Theory Comput· December 2016

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Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.
Moshe Goldsmith, Simone Eckstein, Yacov Ashani, Per Greisen, Haim Leader

Arch Toxicol· November 2016

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Accurate de novo design of hyperstable constrained peptides.
Gaurav Bhardwaj, Vikram Khipple Mulligan, Christopher D Bahl, Jason M Gilmore, Peta J Harvey, Per Jr Greisen

Nature· October 2016

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Computational redesign of metalloenzymes for catalyzing new reactions.
Per Greisen, Sagar D Khare

Methods Mol Biol· May 2015

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Phosphorus binding sites in proteins: structural preorganization and coordination.
Mathias Gruber, Per Greisen, Caroline M Junker, Claus Hélix-Nielsen

J Phys Chem B· February 2014

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Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries.
Izhack Cherny, Per Greisen, Yacov Ashani, Sagar D Khare, Gustav Oberdorfer

ACS Chem Biol· November 2013

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Metallothionein Zn2+- and Cu2+-clusters from first-principles calculations.
Per Greisen, Jakob B Jespersen, Kasper P Kepp

Dalton Trans· February 2012

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Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Sagar D Khare, Yakov Kipnis, Per Greisen, Ryo Takeuchi, Yacov Ashani

Nat Chem Biol· February 2012

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