Publications by authors named "Hal Lewis"

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Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.
Richard A Hartz, Vijay T Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hal Lewis

J Med Chem· June 2023

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Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.
Jay A Markwalder, Aaron J Balog, David K Williams, Susheel J Nara, Ratnakar Reddy, Hal Lewis

Bioorg Med Chem Lett· May 2023

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Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors.
Richard A Hartz, Vijay T Ahuja, Prasanna Sivaprakasam, Hong Xiao, Carol M Krause, Hal Lewis

J Med Chem· March 2023

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Structure-activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors.
Guanglin Luo, Ling Chen, Swanee Jacutin-Porte, Ying Han, Catherine R Burton, Hal A Lewis

Bioorg Med Chem Lett· February 2023

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Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Kyle Parcella, Manoj Patel, Yong Tu, Kyle Eastman, Kevin Peese, Hal Lewis

Bioorg Med Chem· August 2022

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Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
Kyle Parcella, Tao Wang, Kyle Eastman, Zhongxing Zhang, Zhiwei Yin, Hal Lewis

ACS Med Chem Lett· June 2022

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Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.
B Narasimhulu Naidu, Manoj Patel, Brian McAuliffe, Bo Ding, Christopher Cianci, Hal Lewis

J Med Chem· March 2022

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Neutrophil-predominant bullous pemphigoid induced by checkpoint inhibitors: A case series.
Lisa M Morris, Hal A Lewis, Lynn A Cornelius, David Y Chen, Ilana S Rosman

J Cutan Pathol· August 2020

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Pemphigus foliaceus in a patient with gastrointestinal stromal tumor treated with adjuvant imatinib mesylate.
Hal A Lewis, David Y Chen, Ilana S Rosman, Joel Picus, Milan J Anadkat

Dermatol Online J· June 2020

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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Guo Li, Nicholas A Meanwell, Mark R Krystal, David R Langley, B Narasimhulu Naidu, Hal Lewis

J Med Chem· March 2020

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Initial Clinical Guidelines for Co-Occurring Autism Spectrum Disorder and Gender Dysphoria or Incongruence in Adolescents.
John F Strang, Haley Meagher, Lauren Kenworthy, Annelou L C de Vries, Edgardo Menvielle, Hal C Lewis

J Clin Child Adolesc Psychol· March 2019

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5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
Kevin M Peese, Christopher W Allard, Timothy Connolly, Barry L Johnson, Chen Li, Hal A Lewis

J Med Chem· February 2019

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Overuse of Magnetic Resonance Imaging in the Diagnosis and Treatment of Moderate to Severe Osteoarthritis.
Seth L Sherman, Trevor R Gulbrandsen, Hal A Lewis, Martin H Gregory, Nicholas M Capito

Iowa Orthop J· December 2018

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Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Micah T Nelp, Patrick A Kates, John T Hunt, John A Newitt, Aaron Balog, Hal A Lewis

Proc Natl Acad Sci U S A· March 2018

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Dermatology ECHO - an innovative solution to address limited access to dermatology expertise.
Hal Lewis, Mirna Becevic, Danny Myers, Dyann Helming, Rachel Mutrux

Rural Remote Health· February 2018

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Methotrexate-induced cutaneous ulceration in 3 nonpsoriatic patients: Report of a rare side effect.
Hal A Lewis, Kathleen M Nemer, Rebecca J Chibnall, Amy C Musiek

JAAD Case Rep· May 2017

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Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.
Yong-Jin Wu, Jason Guernon, Jianliang Shi, Lawrence Marcin, Mendi Higgins, Hal Lewis

J Med Chem· September 2016

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Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.
Yong-Jin Wu, Jason Guernon, Fukang Yang, Lawrence Snyder, Jianliang Shi, Hal Lewis

ACS Med Chem Lett· March 2016

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Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
Guanglin Luo, Ling Chen, Catherine R Burton, Hong Xiao, Prasanna Sivaprakasam, Hal A Lewis

J Med Chem· February 2016

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Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.
Annette Ehrhardt, W Joon Chung, Louise C Pyle, Wei Wang, Krzysztof Nowotarski, Hal A Lewis

J Biol Chem· January 2016

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Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Prasanna Sivaprakasam, Xiaojun Han, Rita L Civiello, Swanee Jacutin-Porte, Kevin Kish, Hal A Lewis

Bioorg Med Chem Lett· May 2015

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Evidence-based approach of treatment options for postoperative knee pain.
Jack Farr, Ryan Jaggers, Hal Lewis, Andreas Plackis, Seung B Sim

Phys Sportsmed· May 2014

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Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice.
Rachel E Bennett, Thomas J Esparza, Hal A Lewis, Eddie Kim, Christine L Mac Donald

J Neuropathol Exp Neurol· May 2013

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Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Samuel W Gerritz, Christopher Cianci, Sean Kim, Bradley C Pearce, Carol Deminie, Hal A Lewis

Proc Natl Acad Sci U S A· September 2011

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Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Shane Atwell, Christie G Brouillette, Kris Conners, Spencer Emtage, Tarun Gheyi, Hal A Lewis

Protein Eng Des Sel· May 2010

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