Publications by authors named "Han-Cheng Zhang"

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Carba-nucleosides as potent antagonists of the adenosine 5'-diphosphate (ADP) purinergic receptor (P2Y12 on human platelets.
Hong Ye, Cailin Chen, Han-Cheng Zhang, Barbara Haertlein, Tom J Parry

ChemMedChem· May 2008

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Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
Michael J Costanzo, Stephen C Yabut, Han-Cheng Zhang, Kimberley B White, Lawrence de Garavilla

Bioorg Med Chem Lett· March 2008

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Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
Min Amy Xiang, Philip J Rybczynski, Mona Patel, Robert H Chen, David F McComsey, Han-Cheng Zhang

Bioorg Med Chem Lett· December 2007

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Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.
Han-Cheng Zhang, Llorente V R Boñaga, Hong Ye, Claudia K Derian, Bruce P Damiano

Bioorg Med Chem Lett· May 2007

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Synthesis of macrocycles via cobalt-mediated [2 + 2 + 2] cycloadditions.
Llorente V R Boñaga, Han-Cheng Zhang, Alessandro F Moretto, Hong Ye, Diane A Gauthier

J Am Chem Soc· March 2005

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Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.
Han-Cheng Zhang, Claudia K Derian, David F McComsey, Kimberly B White, Hong Ye

J Med Chem· March 2005

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In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Michael J Costanzo, Harold R Almond, Leonard R Hecker, Mary R Schott, Stephen C Yabut, Han-Cheng Zhang

J Med Chem· March 2005

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Cobalt-mediated cyclotrimerisation of bis-alkynes and cyanamides.
Llorente V R Boñaga, Han-Cheng Zhang, Bruce E Maryanoff

Chem Commun (Camb)· November 2004

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3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.
Han-Cheng Zhang, Hong Ye, Bruce R Conway, Claudia K Derian, Michael F Addo

Bioorg Med Chem Lett· June 2004

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Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3beta (GSK-3beta) inhibitors.
David J O'Neill, Lan Shen, Catherine Prouty, Bruce R Conway, Lori Westover, Han-Cheng Zhang

Bioorg Med Chem· June 2004

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RWJ-58259: a selective antagonist of protease activated receptor-1.
Bruce P Damiano, Claudia K Derian, Bruce E Maryanoff, Han-Cheng Zhang, Patricia Andrade Gordon

Cardiovasc Drug Rev· April 2004

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Cyclizations of N-acyliminium ions.
Bruce E Maryanoff, Han-Cheng Zhang, Judith H Cohen, Ignatius J Turchi, Cynthia A Maryanoff

Chem Rev· March 2004

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Cobalt-mediated macrocyclizations. Facile synthesis of 2-oxo pyridinophanes via [2 + 2 + 2] cycloaddition of alpha, omega-diynes and isocyanates.
Llorente V R Boñaga, Han-Cheng Zhang, Diane A Gauthier, Indrasena Reddy, Bruce E Maryanoff

Org Lett· November 2003

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Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.
Han-Cheng Zhang, Kimberly B White, Hong Ye, David F McComsey, Claudia K Derian

Bioorg Med Chem Lett· September 2003

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High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.
Han Cheng Zhang, Kimberly B White, David F McComsey, Michael F Addo, Patricia Andrade-Gordon

Bioorg Med Chem Lett· July 2003

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Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1).
Bruce E Maryanoff, Han-Cheng Zhang, Patricia Andrade-Gordon, Claudia K Derian

Curr Med Chem Cardiovasc Hematol Agents· March 2003

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Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates.
Claudia K Derian, Bruce P Damiano, Michael F Addo, Andrew L Darrow, Michael R D'Andrea, Han-Cheng Zhang

J Pharmacol Exp Ther· February 2003

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Therapeutic potential of protease-activated receptor-1 antagonists.
Claudia K Derian, Bruce E Maryanoff, Han-Cheng Zhang, Patricia Andrade-Gordon

Expert Opin Investig Drugs· February 2003

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