Publications by authors named "Bruce P Damiano"

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The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.
Hua Rong Lu, Bruce P Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde

Biomolecules· September 2023

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Characterization of an anesthetized dog model of transient cardiac ischemia and rapid pacing: a pilot study for preclinical assessment of the potential for proarrhythmic risk of novel drug candidates.
Bruce P Damiano, Henk J van der Linde, Bruno Van Deuren, Yves Somers, Mariusz Lubomirski

J Pharmacol Toxicol Methods· December 2015

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Endothelial lipase is localized to follicular epithelial cells in the thyroid gland and is moderately expressed in adipocytes.
Margery A Connelly, Michael R D'Andrea, Jenson Qi, Keli C Dzordzorme, Bruce P Damiano

J Histochem Cytochem· September 2012

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Phase 0 study of the inhibition of cholesteryl ester transfer protein activity by JNJ-28545595 in plasma from normolipidemic and dyslipidemic humans.
Troy C Sarich, Margery A Connelly, Dorota B Schranz, Atalanta Ghosh, Prasarn Manitpisitkul, Bruce P Damiano

Int J Clin Pharmacol Ther· August 2012

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Arterial antithrombotic activity of rivaroxaban, an orally active factor Xa inhibitor, in a rat electrolytic carotid artery injury model of thrombosis.
Tom J Parry, Zhihong Huang, Cailin Chen, Margery A Connelly, Elisabeth Perzborn, Bruce P Damiano

Blood Coagul Fibrinolysis· December 2011

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A novel fluorogenic substrate for the measurement of endothelial lipase activity.
Andrew L Darrow, Matthew W Olson, Hong Xin, Sharon L Burke, Charles Smith, Bruce P Damiano

J Lipid Res· February 2011

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Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Daniel J Parks, William H Parsons, Raymond W Colburn, Sanath K Meegalla, Shelley K Ballentine, Bruce P Damiano

J Med Chem· January 2011

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Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.
Margery A Connelly, Tom J Parry, Edward C Giardino, Zhihong Huang, Wai-Man Cheung, Bruce P Damiano

J Cardiovasc Pharmacol· May 2010

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Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa.
Edward C Giardino, Barbara J Haertlein, Lawrence de Garavilla, Michael J Costanzo, Bruce P Damiano

Blood Coagul Fibrinolysis· March 2010

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Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.
Tianbao Lu, Thomas Markotan, Shelley K Ballentine, Edward C Giardino, John Spurlino, Bruce P Damiano

J Med Chem· February 2010

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Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.
Edward C Lawson, Diane K Luci, Shyamali Ghosh, William A Kinney, Charles H Reynolds, Bruce P Damiano

J Med Chem· December 2009

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Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor.
Gee-Hong Kuo, Thomas Rano, Patricia Pelton, Keith T Demarest, Alan C Gibbs, Bruce P Damiano

J Med Chem· March 2009

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Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist.
Joseph W Gunnet, Pamela Wines, Min Xiang, Philip Rybczynski, Patricia Andrade-Gordon, Bruce P Damiano

Eur J Pharmacol· August 2008

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Carba-nucleosides as potent antagonists of the adenosine 5'-diphosphate (ADP) purinergic receptor (P2Y12 on human platelets.
Hong Ye, Cailin Chen, Han-Cheng Zhang, Barbara Haertlein, Tom J Parry, Bruce P Damiano

ChemMedChem· May 2008

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Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.
Kevin D Kreutter, Tianbao Lu, Lily Lee, Edward C Giardino, Sharmila Patel, Bruce P Damiano

Bioorg Med Chem Lett· May 2008

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Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats.
Rosemary J Santulli, William A Kinney, Shyamali Ghosh, Bart L Decorte, Li Liu, Bruce P Damiano

J Pharmacol Exp Ther· March 2008

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7-fluoroindazoles as potent and selective inhibitors of factor Xa.
Yu-Kai Lee, Daniel J Parks, Tianbao Lu, Tho V Thieu, Thomas Markotan, Bruce P Damiano

J Med Chem· January 2008

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Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment.
Diane K Luci, Shyamali Ghosh, Charles E Smith, Jenson Qi, Yuanping Wang, Bruce P Damiano

Bioorg Med Chem Lett· December 2007

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Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
Min Amy Xiang, Philip J Rybczynski, Mona Patel, Robert H Chen, David F McComsey, Bruce P Damiano

Bioorg Med Chem Lett· December 2007

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Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.
Han-Cheng Zhang, Llorente V R Boñaga, Hong Ye, Claudia K Derian, Bruce P Damiano

Bioorg Med Chem Lett· May 2007

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Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
Michael N Greco, Michael J Hawkins, Eugene T Powell, Harold R Almond, Lawrence de Garavilla, Bruce P Damiano

J Med Chem· April 2007

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Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa.
Bruce E Maryanoff, David F McComsey, Michael J Costanzo, Stephen C Yabut, Tianbao Lu, Bruce P Damiano

Chem Biol Drug Des· July 2006

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Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent.
Edward C Lawson, Rosemary J Santulli, Alexey B Dyatkin, Scott A Ballentine, William M Abraham, Bruce P Damiano

Bioorg Med Chem· June 2006

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Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists.
Yong Gong, J Kent Barbay, Alexey B Dyatkin, Tamara A Miskowski, Edward S Kimball, Bruce P Damiano

J Med Chem· June 2006

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Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists.
Alexey B Dyatkin, Yong Gong, Tamara A Miskowski, Edward S Kimball, Stephen M Prouty, Bruce P Damiano

Bioorg Med Chem· December 2005

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