Publications by authors named "Keith T Demarest"

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4
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.
Shyh-Ming Yang, Yuting Tang, Thomas Rano, Huajun Lu, Gee-Hong Kuo, Keith T Demarest

Bioorg Med Chem Lett· March 2014

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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.
Shyh-Ming Yang, Yuting Tang, Rui Zhang, Huajun Lu, Gee-Hong Kuo, Keith T Demarest

Bioorg Med Chem Lett· December 2013

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Beneficial metabolic effects of CB1R anti-sense oligonucleotide treatment in diet-induced obese AKR/J mice.
Yuting Tang, George Ho, Yaxin Li, Meghan A Hall, Robert L Hills, Keith T Demarest

PLoS One· February 2013

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Phase 0 study of the inhibition of cholesteryl ester transfer protein activity by JNJ-28545595 in plasma from normolipidemic and dyslipidemic humans.
Troy C Sarich, Margery A Connelly, Dorota B Schranz, Atalanta Ghosh, Prasarn Manitpisitkul, Keith T Demarest

Int J Clin Pharmacol Ther· August 2012

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The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.
Jenson Qi, Wensheng Lang, John G Geisler, Ping Wang, Ioanna Petrounia, Keith T Demarest

J Lipid Res· June 2012

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Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
Graeme Semple, Albert Ren, Beatriz Fioravanti, Guillherme Pereira, Imelda Calderon, Keith T Demarest

Bioorg Med Chem Lett· May 2011

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Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.
Margery A Connelly, Tom J Parry, Edward C Giardino, Zhihong Huang, Wai-Man Cheung, Keith T Demarest

J Cardiovasc Pharmacol· May 2010

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Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors.
Aihua Wang, Catherine P Prouty, Patricia D Pelton, Maria Yong, Keith T Demarest

Bioorg Med Chem Lett· February 2010

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Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.
Thomas A Rano, Ellen Sieber-McMaster, Patricia D Pelton, Maria Yang, Keith T Demarest

Bioorg Med Chem Lett· May 2009

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Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor.
Gee-Hong Kuo, Thomas Rano, Patricia Pelton, Keith T Demarest, Alan C Gibbs

J Med Chem· March 2009

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Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist.
Joseph W Gunnet, Pamela Wines, Min Xiang, Philip Rybczynski, Patricia Andrade-Gordon, Keith T Demarest

Eur J Pharmacol· August 2008

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Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
Min Amy Xiang, Philip J Rybczynski, Mona Patel, Robert H Chen, David F McComsey, Keith T Demarest

Bioorg Med Chem Lett· December 2007

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Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.
Jay M Matthews, Xiaoli Chen, Ellen Cryan, Dennis J Hlasta, Philip J Rybczynski, Keith T Demarest

Bioorg Med Chem Lett· December 2007

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Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists.
Fengbin Song, Songfeng Lu, Joe Gunnet, Jun Z Xu, Pam Wines, Keith T Demarest

J Med Chem· June 2007

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Human epidermoid A431 cells express functional nicotinic acid receptor HM74a.
Lubing Zhou, Yuting Tang, Ellen V Cryan, Keith T Demarest

Mol Cell Biochem· January 2007

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Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists.
Sigmond G Johnson, Joseph W Gunnet, John B Moore, William Miller, Pam Wines, Keith T Demarest

Bioorg Med Chem Lett· July 2006

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Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A.
Yuting Tang, Lubing Zhou, Joseph W Gunnet, Pamela G Wines, Ellen V Cryan, Keith T Demarest

Biochem Biophys Res Commun· June 2006

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Characterization of RWJ-351647, a novel nonpeptide vasopressin V2 receptor antagonist.
Joseph W Gunnet, Jay M Matthews, Bruce E Maryanoff, Lawrence de Garavilla, Patricia Andrade-Gordon, Keith T Demarest

Clin Exp Pharmacol Physiol· April 2006

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Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.
Xiaoyan Zhang, Maud Urbanski, Mona Patel, Geoffrey G Cox, Roxanne E Zeck, Keith T Demarest

Bioorg Med Chem Lett· March 2006

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Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.
Xiaoyan Zhang, Maud Urbanski, Mona Patel, Roxanne E Zeck, Geoffrey G Cox, Keith T Demarest

Bioorg Med Chem Lett· December 2005

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Sustained aquaretic effect of the V2-AVP receptor antagonist, RWJ-351647, in cirrhotic rats with ascites and water retention.
Josefa Ros, Guillermo Fernández-Varo, Javier Muñoz-Luque, Vicente Arroyo, Juan Rodés, Keith T Demarest

Br J Pharmacol· November 2005

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Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors.
Joseph Dudash, Yongzheng Zhang, John B Moore, Richard Look, Yin Liang, Keith T Demarest

Bioorg Med Chem Lett· November 2005

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Distinctive and synergistic signaling of human adenosine A2a and dopamine D2L receptors in CHO cells.
Yuting Tang, Keith T Demarest

J Recept Signal Transduct Res· November 2005

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Nuclear receptors as potential targets for modulating reverse cholesterol transport.
Patricia D Pelton, Mona Patel, Keith T Demarest

Curr Top Med Chem· June 2005

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Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.
Han-Cheng Zhang, Claudia K Derian, David F McComsey, Kimberly B White, Hong Ye, Keith T Demarest

J Med Chem· March 2005

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