Publications by authors named "Hans Hebert"

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The gut microbiota influences blood-brain barrier permeability in mice.
Viorica Braniste, Maha Al-Asmakh, Czeslawa Kowal, Farhana Anuar, Afrouz Abbaspour, Miklós Tóth, Agata Korecka, Nadja Bakocevic, Lai Guan Ng, Parag Kundu

Sci Transl Med· November 2014

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Structure of the iminium reaction intermediate in an engineered aldolase explains the carboligation activity toward arylated ketones and aldehydes.
Hans Hebert, Eda Sönmez, Pasi Purhonen, Mikael Widersten

Structure· September 2024

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Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain.
Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Hans Hebert

Protein Sci· July 2024

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The membrane-cytoplasmic linker defines activity of FtsH proteases in Pseudomonas aeruginosa clone C.
Gina D Mawla, Shady M Kamal, Lian-Ying Cao, Pasi Purhonen, Hans Hebert

J Biol Chem· February 2024

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Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation.
Gefei Chen, Axel Leppert, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Hans Hebert

Commun Biol· May 2023

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Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue.
Gefei Chen, Yuniesky Andrade-Talavera, Xueying Zhong, Sameer Hassan, Henrik Biverstål, Hans Hebert

RSC Chem Biol· November 2022

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A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function.
Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K Karneva, Hans Hebert

JCI Insight· September 2022

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A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient Remodeling Activity.
Eunhye Lee, Chanshin Kang, Pasi Purhonen, Hans Hebert, Karim Bouazoune

J Mol Biol· September 2021

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Publisher Correction: Crocus-derived compounds alter the aggregation pathway of Alzheimer's Disease - associated beta amyloid protein.
Nikolaos Stavros Koulakiotis, Pasi Purhonen, Evangelos Gikas, Hans Hebert, Anthony Tsarbopoulos

Sci Rep· February 2021

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Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.
Alena Stsiapanava, Chenrui Xu, Martina Brunati, Sara Zamora-Caballero, Céline Schaeffer, Hans Hebert

EMBO J· December 2020

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Crocus-derived compounds alter the aggregation pathway of Alzheimer's Disease: associated beta amyloid protein.
Nikolaos Stavros Koulakiotis, Pasi Purhonen, Evangelos Gikas, Hans Hebert, Anthony Tsarbopoulos

Sci Rep· October 2020

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Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.
Ramakrishnan B Kumar, Pasi Purhonen, Hans Hebert, Caroline Jegerschöld

PLoS One· September 2020

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The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
Taeyang Jung, Baehyun Shin, Giorgio Tamo, Hyeongju Kim, Ravi Vijayvargia, Hans Hebert

Structure· September 2020

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Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation.
Helen Poska, Axel Leppert, Helene Tigro, Xueying Zhong, Margit Kaldmäe, Hans Hebert

Sci Rep· June 2020

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Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro.
Gefei Chen, Yuniesky Andrade-Talavera, Simone Tambaro, Axel Leppert, Harriet E Nilsson, Hans Hebert

Commun Biol· January 2020

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CryoEM: a crystals to single particles round-trip.
Hans Hebert

Curr Opin Struct Biol· October 2019

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Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity.
Gijeong Kim, Liyana Azmi, Seongmin Jang, Taeyang Jung, Hans Hebert

Nat Commun· October 2019

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Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.
Seongmin Jang, Chanshin Kang, Han-Sol Yang, Taeyang Jung, Hans Hebert

Genes Dev· June 2019

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A spidroin-derived solubility tag enables controlled aggregation of a designed amyloid protein.
Médoune Sarr, Nina Kronqvist, Gefei Chen, Rihards Aleksis, Pasi Purhonen, Hans Hebert

FEBS J· May 2018

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Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.
Sergio Trillo-Muyo, Harriet E Nilsson, Christian V Recktenwald, Anna Ermund, Caroline Ridley, Hans Hebert

J Biol Chem· April 2018

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Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding.
Jungmin Yoon, Seung Joong Kim, Sojin An, Saehyun Cho, Alexander Leitner, Hans Hebert

J Mol Biol· March 2018

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Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface.
Christopher A G Söderberg, Cecilia Månsson, Katja Bernfur, Gudrun Rutsdottir, Johan Härmark, Hans Hebert

Sci Rep· March 2018

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Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state.
Gefei Chen, Axel Abelein, Harriet E Nilsson, Axel Leppert, Yuniesky Andrade-Talavera, Hans Hebert

Nat Commun· December 2017

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Structures of apolipoprotein A-I in high density lipoprotein generated by electron microscopy and biased simulations.
Lin Zhu, Jitka Petrlova, Peter Gysbers, Hans Hebert, Stefan Wallin

Biochim Biophys Acta Gen Subj· November 2017

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The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin.
Anna Ermund, Lauren N Meiss, Ana M Rodriguez-Pineiro, Andrea Bähr, Harriet E Nilsson, Hans Hebert

Biochem Biophys Res Commun· October 2017

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Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation.
Qie Kuang, Pasi Purhonen, Johan Ålander, Richard Svensson, Veronika Hoogland, Hans Hebert

Sci Rep· August 2017

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