Publications by authors named "Hans Hilpert"

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Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.
Matteo Oliverio, Elena Schmidt, Jan Mauer, Catherina Baitzel, Nils Hansmeier, Hans Hilpert

Nat Cell Biol· March 2016

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Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.
Helmut Jacobsen, Laurence Ozmen, Antonello Caruso, Robert Narquizian, Hans Hilpert

J Neurosci· August 2014

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Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.
Hans Hilpert, Harald Mauser, Roland Humm, Lilli Anselm, Holger Kuehne

J Med Chem· December 2013

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BACE1 inhibitors: a head group scan on a series of amides.
Thomas J Woltering, Wolfgang Wostl, Hans Hilpert, Mark Rogers-Evans, Emmanuel Pinard

Bioorg Med Chem Lett· July 2013

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Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.
David W Banner, Bernard Gsell, Jörg Benz, Julian Bertschinger, Dominique Burger, Hans Hilpert

Acta Crystallogr D Biol Crystallogr· June 2013

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β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.
Hans Hilpert, Wolfgang Guba, Thomas J Woltering, Wolfgang Wostl, Emmanuel Pinard

J Med Chem· May 2013

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Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
Daria Esterházy, Ina Stützer, Haiyan Wang, Markus P Rechsteiner, Jeremy Beauchamp, Hans Hilpert

Cell Metab· September 2011

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Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice.
Ilze Bot, Martine Bot, Sandra H van Heiningen, Peter J van Santbrink, Inge M Lankhuizen, Hans Hilpert

Cardiovasc Res· January 2011

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Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.
Lilli Anselm, David W Banner, Jörg Benz, Katrin Groebke Zbinden, Jacques Himber, Hans Hilpert

Bioorg Med Chem Lett· September 2010

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Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists.
Uwe Grether, Agnes Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Hans Hilpert

ChemMedChem· June 2009

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Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Agnes Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Markus Boehringer, Hans Hilpert

Bioorg Med Chem Lett· May 2009

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Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.
Bernd Kuhn, Hans Hilpert, Jörg Benz, Alfred Binggeli, Uwe Grether

Bioorg Med Chem Lett· August 2006

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Efficient synthesis of novel NK1 receptor antagonists: selective 1,4-addition of grignard reagents to 6-chloronicotinic acid derivatives.
Fabienne Hoffmann-Emery, Hans Hilpert, Michelangelo Scalone, Pius Waldmeier

J Org Chem· March 2006

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