Publications by authors named "Helmut Jacobsen"

Claim this Profile
R
RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta-site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain.
Michael Honer, Alessandra Polara, Hiroto Kuwabara, Helmut Jacobsen, Axel Pähler

J Labelled Comp Radiopharm· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies.
Aurélien Lathuilière, Vanessa Laversenne, Alberto Astolfo, Erhard Kopetzki, Helmut Jacobsen

Brain· May 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cargo Delivery into the Brain by in vivo identified Transport Peptides.
Eduard Urich, Roland Schmucki, Nadine Ruderisch, Eric Kitas, Ulrich Certa, Helmut Jacobsen

Sci Rep· September 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.
Helmut Jacobsen, Laurence Ozmen, Antonello Caruso, Robert Narquizian, Hans Hilpert, Bjoern Jacobsen

J Neurosci· August 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation.
Aurélien Lathuilière, Bernd Bohrmann, Erhard Kopetzki, Christoph Schweitzer, Helmut Jacobsen

Biomaterials· January 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
BACE1 inhibitors: a head group scan on a series of amides.
Thomas J Woltering, Wolfgang Wostl, Hans Hilpert, Mark Rogers-Evans, Emmanuel Pinard, Helmut Jacobsen

Bioorg Med Chem Lett· July 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Î
β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.
Hans Hilpert, Wolfgang Guba, Thomas J Woltering, Wolfgang Wostl, Emmanuel Pinard, Helmut Jacobsen

J Med Chem· May 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Morphologic and functional effects of gamma secretase inhibition on splenic marginal zone B cells.
Maria Cristina de Vera Mudry, Franziska Regenass-Lechner, Laurence Ozmen, Bernd Altmann, Matthias Festag, Helmut Jacobsen

Int J Alzheimers Dis· January 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat.
Leon M Tai, Helmut Jacobsen, Laurence Ozmen, Alexander Flohr, Roland Jakob-Roetne

J Pharmacokinet Pharmacodyn· June 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Aminothiazoles as γ-secretase modulators.
Thomas Lübbers, Alexander Flohr, Synese Jolidon, Pascale David-Pierson, Helmut Jacobsen

Bioorg Med Chem Lett· November 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu) and active metabolite.
Lothar Lindemann, Helmut Jacobsen, Diana Schuhbauer, Frederic Knoflach, Silvia Gatti

Eur J Pharmacol· February 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.
Leopoldo Luistro, Wei He, Melissa Smith, Kathryn Packman, Maria Vilenchik, Helmut Jacobsen

Cancer Res· October 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Alzheimer's disease: from pathology to therapeutic approaches.
Roland Jakob-Roetne, Helmut Jacobsen

Angew Chem Int Ed Engl· June 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.
Laurence Ozmen, Anita Albientz, Christian Czech, Helmut Jacobsen

Neurodegener Dis· February 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
ProNGF inhibits NGF-mediated TrkA activation in PC12 cells.
Bettina Sobottka, Dieter Reinhardt, Manfred Brockhaus, Helmut Jacobsen, Friedrich Metzger

J Neurochem· December 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Richard M Page, Karlheinz Baumann, Masanori Tomioka, Blanca I Pérez-Revuelta, Akio Fukumori, Helmut Jacobsen

J Biol Chem· January 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors.
Eric A Kitas, Guido Galley, Roland Jakob-Roetne, Alexander Flohr, Wolfgang Wostl, Helmut Jacobsen

Bioorg Med Chem Lett· January 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.
Jens-Uwe Peters, Guido Galley, Helmut Jacobsen, Christian Czech, Pascale David-Pierson

Bioorg Med Chem Lett· November 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase.
Christian Czech, Mark P Burns, Lilit Vardanian, Angelique Augustin, Helmut Jacobsen

J Neurochem· May 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
BACE/APPV717F double-transgenic mice develop cerebral amyloidosis and inflammation.
Laurence Ozmen, Marie Woolley, Anita Albientz, Marie-Therese Miss, Peter Nelboeck, Helmut Jacobsen

Neurodegener Dis· October 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
Markus von Kienlin, Basil Künnecke, Friedrich Metzger, Guido Steiner, J Grayson Richards, Helmut Jacobsen

Neurobiol Dis· February 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.
J Grayson Richards, Guy A Higgins, Abdel-Mouttalib Ouagazzal, Laurence Ozmen, James N C Kew, Helmut Jacobsen

J Neurosci· October 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.
Philipp J Kahle, Manuela Neumann, Laurence Ozmen, Veronika Muller, Helmut Jacobsen

EMBO Rep· June 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis