Publications by authors named "Hans Locher"

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Discovery and Structure-Activity Relationship of Cadazolid: A First-In-Class Quinoxolidinone Antibiotic for the Treatment of Infection.
Georg Rueedi, Philippe Panchaud, Astrid Friedli, Jean-Luc Specklin, Christian Hubschwerlen, Hans H Locher

J Med Chem· June 2024

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Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resistant Enterobacteriaceae.
Matthias Schuster, Emile Brabet, Kathryn K Oi, Nicolas Desjonquères, Kerstin Moehle, Hans Locher

Sci Adv· May 2023

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Identification of Genes Required for Resistance to Peptidomimetic Antibiotics by Transposon Sequencing.
Alessandra Vitale, Gabriella Pessi, Matthias Urfer, Hans H Locher, Katja Zerbe

Front Microbiol· July 2020

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Antimicrobial activity of POL7306 tested against clinical isolates of Gram-negative bacteria collected worldwide.
Helio S Sader, Paul R Rhomberg, Leonard R Duncan, Hans H Locher, Glenn E Dale

J Antimicrob Chemother· June 2020

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Optimization of LpxC Inhibitor Lead Compounds Focusing on Efficacy and Formulation for High Dose Intravenous Administration.
Philippe Panchaud, Jean-Philippe Surivet, Stefan Diethelm, Anne-Catherine Blumstein, Jean-Christophe Gauvin, Hans H Locher

J Med Chem· January 2020

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Chimeric peptidomimetic antibiotics against Gram-negative bacteria.
Anatol Luther, Matthias Urfer, Michael Zahn, Maik Müller, Shuang-Yan Wang, Hans H Locher

Nature· December 2019

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Author Correction: Chimeric peptidomimetic antibiotics against Gram-negative bacteria.
Anatol Luther, Matthias Urfer, Michael Zahn, Maik Müller, Shuang-Yan Wang, Hans H Locher

Nature· December 2019

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Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic.
Alain Scaiola, Marc Leibundgut, Daniel Boehringer, Patrick Caspers, Daniel Bur, Hans H Locher

Sci Rep· April 2019

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Time-kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile.
Kirsty Skinner, Stephen Birchall, David Corbett, Pia Thommes, Hans H Locher

J Med Microbiol· September 2018

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Different Resistance Mechanisms for Cadazolid and Linezolid in Clostridium difficile Found by Whole-Genome Sequencing Analysis.
Patrick Caspers, Hans H Locher, Philippe Pfaff, Sarah Diggelmann, Georg Rueedi

Antimicrob Agents Chemother· August 2017

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Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.
Jean-Philippe Surivet, Cornelia Zumbrunn, Thierry Bruyère, Daniel Bur, Christopher Kohl, Hans H Locher

J Med Chem· May 2017

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Cadazolid Does Not Promote Intestinal Colonization of Vancomycin-Resistant Enterococci in Mice.
Peter Seiler, Michel Enderlin-Paput, Philippe Pfaff, Maria Weiss, Daniel Ritz, Hans H Locher

Antimicrob Agents Chemother· January 2016

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Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.
Jean-Philippe Surivet, Cornelia Zumbrunn, Georg Rueedi, Daniel Bur, Thierry Bruyère, Hans Locher

J Med Chem· January 2015

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In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.
Hans H Locher, Peter Seiler, Xinhua Chen, Susanne Schroeder, Philippe Pfaff

Antimicrob Agents Chemother· September 2014

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Investigations of the mode of action and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.
Hans H Locher, Patrick Caspers, Thierry Bruyère, Susanne Schroeder, Philippe Pfaff

Antimicrob Agents Chemother· September 2014

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Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.
Jean-Philippe Surivet, Cornelia Zumbrunn, Georg Rueedi, Christian Hubschwerlen, Daniel Bur, Hans Locher

J Med Chem· September 2013

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Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
Jean-Philippe Surivet, Roland Lange, Christian Hubschwerlen, Wolfgang Keck, Jean-Luc Specklin, Hans Locher

Bioorg Med Chem Lett· November 2012

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Dimers of nostocarboline with potent antibacterial activity.
Hans H Locher, Daniel Ritz, Philippe Pfaff, Mika Gaertner, Andreja Knezevic

Chemotherapy· December 2010

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The targets of currently used antibacterial agents: lessons for drug discovery.
Roland P Lange, Hans H Locher, Pierre C Wyss, Rudolf L Then

Curr Pharm Des· March 2008

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Biomimetic total synthesis and antimicrobial evaluation of anachelin H.
Karl Gademann, Yann Bethuel, Hans H Locher, Christian Hubschwerlen

J Org Chem· October 2007

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Potent algicides based on the cyanobacterial alkaloid nostocarboline.
Judith F Blom, Tobias Brütsch, Damien Barbaras, Yann Bethuel, Hans H Locher

Org Lett· February 2006

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Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.
Christian Hubschwerlen, Jean-Luc Specklin, Daniel K Baeschlin, Yves Borer, Sascha Haefeli, Hans H Locher

Bioorg Med Chem Lett· December 2003

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Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.
Pierre C Wyss, Paul Gerber, Peter G Hartman, Christian Hubschwerlen, Hans Locher

J Med Chem· June 2003

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Design, synthesis and biological evaluation of oxazolidinone-quinolone hybrids.
Christian Hubschwerlen, Jean Luc Specklin, Christine Sigwalt, Susanne Schroeder, Hans H Locher

Bioorg Med Chem· May 2003

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