Publications by authors named "Haresh Ajani"

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Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety.
Okka Scholz, Elena Huß, Silke Otter, Diran Herebian, Anna Hamacher, Haresh Ajani

Mol Metab· September 2023

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Synthesis of 4-styrylpyrazoles and Evaluation of their Inhibitory Effects on Cyclin-dependent Kinases.
Daniel Toman, Radek Jorda, Haresh Ajani, Vladimír Kryštof, Petr Cankař

Med Chem· March 2022

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3-Pyrazolo[4,3-]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
Neetu Dayal, Eva Řezníčková, Delmis E Hernandez, Miroslav Peřina, Sandra Torregrosa-Allen, Haresh Ajani

J Med Chem· August 2021

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The synthesis and cholinesterase inhibitory activities of solasodine analogues with seven-membered F ring.
Urszula Kiełczewska, Radek Jorda, Gabriel Gonzalez, Jacek W Morzycki, Haresh Ajani

J Steroid Biochem Mol Biol· January 2021

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Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors.
Cemal Köprülüoğlu, Milan Dejmek, Michal Šála, Haresh Ajani, Hubert Hřebabecký

J Mol Recognit· August 2020

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Polysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE Production with Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema.
Filip Kalčic, Viktor Kolman, Haresh Ajani, Zdeněk Zídek, Zlatko Janeba

ChemMedChem· August 2020

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Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity.
Eva Řezníčková, Tomáš Gucký, Veronika Kováčová, Haresh Ajani, Radek Jorda

Eur J Med Chem· November 2019

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Tetrahydropyrazolo[1,5-a]pyridine-fused steroids and their in vitro biological evaluation in prostate cancer.
Radek Jorda, Susana M M Lopes, Eva Řezníčková, Haresh Ajani, António V Pereira

Eur J Med Chem· September 2019

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Imidazo[1,2-c]pyrimidin-5(6H)-one as a novel core of cyclin-dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring.
Haresh Ajani, Josef Jansa, Cemal Köprülüoğlu, Pavel Hobza, Vladimír Kryštof

J Mol Recognit· September 2018

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Discovery of N-(4-Amino-cyclohexyl)-9-cyclopentyl- N-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations.
Tomáš Gucký, Eva Řezníčková, Tereza Radošová Muchová, Radek Jorda, Zuzana Klejová, Haresh Ajani

J Med Chem· May 2018

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Superior Performance of the SQM/COSMO Scoring Functions in Native Pose Recognition of Diverse Protein-Ligand Complexes in Cognate Docking.
Haresh Ajani, Adam Pecina, Saltuk M Eyrilmez, Jindřich Fanfrlík, Susanta Haldar

ACS Omega· July 2017

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Unraveling the Structure-Affinity Relationship between Cucurbit[n]urils (n = 7, 8) and Cationic Diamondoids.
David Sigwalt, Marina Šekutor, Liping Cao, Peter Y Zavalij, Jiří Hostaš, Haresh Ajani

J Am Chem Soc· March 2017

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Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.
Michaela Hylsová, Benoit Carbain, Jindřich Fanfrlík, Lenka Musilová, Susanta Haldar, Haresh Ajani

Eur J Med Chem· January 2017

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A Nexus between Theory and Experiment: Non-Empirical Quantum Mechanical Computational Methodology Applied to Cucurbit[n]uril⋅Guest Binding Interactions.
Jiří Hostaš, David Sigwalt, Marina Šekutor, Haresh Ajani, Matúš Dubecký

Chemistry· November 2016

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IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors.
Alexandra Cousido-Siah, Francesc X Ruiz, Jindřich Fanfrlík, Joan Giménez-Dejoz, André Mitschler, Haresh Ajani

ACS Chem Biol· October 2016

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Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.
Vladimír Pejchal, Šárka Štěpánková, Marcela Pejchalová, Karel Královec, Radim Havelek, Haresh Ajani

Bioorg Med Chem· April 2016

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Effect of introducing aib in a designed helical inhibitor of hdm2-p53 interaction: A molecular dynamics study.
Sarbani Chattopadhyay, Haresh Ajani, Gautam Basu

Biopolymers· January 2016

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Characteristics of a σ-Hole and the Nature of a Halogen Bond.
Michal H Kolář, Palanisamy Deepa, Haresh Ajani, Adam Pecina, Pavel Hobza

Top Curr Chem· September 2015

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Malonate-based inhibitors of mammalian serine racemase: kinetic characterization and structure-based computational study.
Barbora Vorlová, Dana Nachtigallová, Jana Jirásková-Vaníčková, Haresh Ajani, Petr Jansa

Eur J Med Chem· January 2015

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Synthesis and structure-activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: application of weakly basic sulfoximine group as novel S4 binding element.
Vrajesh Pandya, Mukul Jain, Ganes Chakrabarti, Hitesh Soni, Bhavesh Parmar, Haresh Ajani

Eur J Med Chem· December 2012

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