Publications by authors named "Hartmut Weiler"

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The pivotal role of von Willebrand factor binding to platelet αIIbβ3 in stabilizing the formation of a platelet plug at sites of injury.
Qizhen Shi, Jeremy G Mattson, Patricia A Morateck, Pamela A Christopherson, Jocelyn A Schroeder, Hartmut Weiler

Haematologica· October 2025

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Coagulation proteases modulate nucleic acid uptake and cGAS-STING-IFN induction in the tumor microenvironment.
Petra Wilgenbus, Jennifer Pott, Sven Pagel, Claudius Witzler, Jennifer Royce, Hartmut Weiler

JCI Insight· September 2025

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TF-FVIIa PAR2-β-Arrestin Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection of Mice.
Meike Kespohl, Carl Christoph Goetzke, Nadine Althof, Clara Bredow, Nicolas Kelm, Hartmut Weiler

Arterioscler Thromb Vasc Biol· April 2024

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Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma.
Shivani Bansal, Yaoxiang Li, Sunil Bansal, William Klotzbier, Baldev Singh, Hartmut Weiler

Metabolites· April 2024

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Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling.
Hortensia Zelaya, Kristin Grunz, T Son Nguyen, Anxhela Habibi, Claudius Witzler, Hartmut Weiler

Blood· March 2024

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EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells.
Meilang Xue, Haiyan Lin, Hai Po Helena Liang, Lara Bereza-Malcolm, Tom Lynch, Hartmut Weiler

Rheumatology (Oxford)· February 2024

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A recombinant signalling-selective activated protein C that lacks anticoagulant activity is efficacious and safe in cutaneous wound preclinical models.
Ruilong Zhao, Meilang Xue, Haiyan Lin, Margaret Smith, Helena Liang, Hartmut Weiler

Wound Repair Regen· January 2024

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Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
Meilang Xue, Christopher J Jackson, Haiyan Lin, Ruilong Zhao, Hai Po H Liang, Hartmut Weiler

Int J Mol Sci· January 2024

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Platelet tissue factor pathway inhibitor-α dampens cardiac thrombosis and associated fibrosis in mice.
Susan A Maroney, Amy E Siebert, Nicholas D Martinez, Mark Rasmussen, Julie A Peterson, Hartmut Weiler

J Thromb Haemost· March 2023

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Protease- and cell type-specific activation of protease-activated receptor 2 in cutaneous inflammation.
Maria Isabel Fleischer, Nadine Röhrig, Verena K Raker, Juliane Springer, Detlef Becker, Hartmut Weiler

J Thromb Haemost· December 2022

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The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse.
Sachiko Kanaji, Yosuke Morodomi, Hartmut Weiler, Alessandro Zarpellon, Robert R Montgomery

Haematologica· September 2022

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A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD.
Qizhen Shi, Scot A Fahs, Jeremy G Mattson, Hongyin Yu, Crystal L Perry, Hartmut Weiler

Blood Adv· May 2022

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Blocking hemophilic arthropathy.
Qizhen Shi, Hartmut Weiler

Blood· May 2022

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Coagulation Factor IIIa () Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype.
Saravanan Subramaniam, Jiandong Liu, Craig Fletcher, Ramani Ramchandran, Hartmut Weiler

Front Cell Dev Biol· March 2022

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Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin.
Vijayalakshmi Sridharan, Kristin A Johnson, Reid D Landes, Maohua Cao, Preeti Singh, Hartmut Weiler

PLoS One· October 2021

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Thromboelastometry assessment of hemostatic properties in various murine models with coagulopathy and the effect of factor VIII therapeutics.
Jocelyn A Schroeder, Erin A Kuether, Juan Fang, Weiqing Jing, Hartmut Weiler

J Thromb Haemost· October 2021

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Bleeding diathesis in mice lacking JAK2 in platelets.
Nathan Eaton, Saravanan Subramaniam, Marie L Schulte, Caleb Drew, David Jakab, Hartmut Weiler

Blood Adv· August 2021

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A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C).
Saravanan Subramaniam, Yamini Ogoti, Irene Hernandez, Mark Zogg, Fady Botros, Hartmut Weiler

Blood Adv· July 2021

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Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells.
Hemant Giri, Sumith R Panicker, Xiaofeng Cai, Indranil Biswas, Hartmut Weiler

Proc Natl Acad Sci U S A· March 2021

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Tissue factor pathway inhibitor is required for cerebrovascular development in mice.
Susan A Maroney, Randal J Westrick, Audrey C Cleuren, Nicholas D Martinez, Amy E Siebert, Hartmut Weiler

Blood· January 2021

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Macrophage protease-activated receptor 2 regulates fetal liver erythropoiesis in mice.
Mona Saffarzadeh, Kristin Grunz, T Son Nguyen, Young K Lee, Maki Kitano, Hartmut Weiler

Blood Adv· November 2020

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Synthesis and initial pharmacology of dual-targeting ligands for putative complexes of integrin αVβ3 and PAR2.
Mark W Majewski, Disha M Gandhi, Trudy Holyst, Zhengli Wang, Irene Hernandez, Hartmut Weiler

RSC Med Chem· August 2020

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The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression.
Qizhen Shi, Jeremy G Mattson, Scot A Fahs, Aron M Geurts, Hartmut Weiler

Blood Adv· January 2020

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A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9.
Jessica Garcia, Veronica H Flood, Sandra L Haberichter, Scot A Fahs, Jeremy G Mattson, Hartmut Weiler

Res Pract Thromb Haemost· January 2020

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The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis.
British Fields, Ann DeLaForest, Mark Zogg, Jennifer May, Catherine Hagen, Hartmut Weiler

Sci Rep· December 2019

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