Publications by authors named "Heather Halem"

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Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells.
Thomas Cuny, Thomas Graillon, Célines Defilles, Rakesh Datta, Shengwen Zhang, Heather A Halem

Pituitary· June 2021

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TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice.
Heather A Halem, Ute Hochgeschwender, Jeong Keun Rih, Richard Nelson, G Allan Johnson

Endocrinology· August 2020

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A Somatostatin Receptor Subtype-3 (SST) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors.
Mari C Vázquez-Borrego, Vandana Gupta, Alejandro Ibáñez-Costa, Manuel D Gahete, Eva Venegas-Moreno, Heather Halem

Clin Cancer Res· February 2020

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Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131.
Lex Van der Ploeg, Haley Laken, Shubh Sharma, Rakesh Datta, Heather Halem

Life Sci· July 2014

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Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques.
Paul Kievit, Heather Halem, Daniel L Marks, Jesse Z Dong, Maria M Glavas

Diabetes· February 2013

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Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
Xiangdong Su, Heather A Halem, Mark P Thomas, Cecile Moutrille, Michael D Culler

Bioorg Med Chem· November 2012

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Adropin deficiency is associated with increased adiposity and insulin resistance.
K Ganesh Kumar, Jingying Zhang, Su Gao, Jari Rossi, Owen P McGuinness, Heather H Halem

Obesity (Silver Spring)· July 2012

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Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model.
Sandra Palus, Robert Schur, Yoshihiro J Akashi, Barbara Bockmeyer, Rakesh Datta, Heather Halem

PLoS One· May 2012

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Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity.
Paul T Pfluger, Tamara R Castañeda, Kristy M Heppner, Sabine Strassburg, Traci Kruthaupt, Heather Halem

Physiol Behav· November 2011

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Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1.
Xiangdong Su, Fabienne Pradaux-Caggiano, Nigel Vicker, Mark P Thomas, Heather Halem

ChemMedChem· September 2011

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Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
Xiangdong Su, Nigel Vicker, Mark P Thomas, Fabienne Pradaux-Caggiano, Heather Halem

ChemMedChem· August 2011

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Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors.
Xiangdong Su, Fabienne Pradaux-Caggiano, Mark P Thomas, Michelle W Y Szeto, Heather A Halem

ChemMedChem· July 2010

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No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure.
Yoshihiro J Akashi, Sandra Palus, Rakesh Datta, Heather Halem, John E Taylor

Int J Cardiol· November 2009

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Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.
K Ganesh Kumar, Gregory M Sutton, Jesse Z Dong, Pierre Roubert, Pascale Plas, Heather A Halem

Peptides· October 2009

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Novel melanocortin-4 receptor agonists that decrease food intake and body weight.
Jesse Z Dong, Daniel B DeOliveira, Heather A Halem, John E Taylor, Pierre Roubert

Adv Exp Med Biol· June 2009

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GHS-1a agonists that effectively stimulate food intake and body weight gain.
Jesse Z Dong, Jundong Zhang, John E Taylor, Heather A Halem, Rakesh Datta

Adv Exp Med Biol· June 2009

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Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Xiangdong Su, Nigel Vicker, Melanie Trusselle, Heather Halem, Michael D Culler

Mol Cell Endocrinol· March 2009

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Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.
K Ganesh Kumar, James L Trevaskis, Daniel D Lam, Gregory M Sutton, Robert A Koza, Heather A Halem

Cell Metab· December 2008

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Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats.
Sabine Strassburg, Stefan D Anker, Tamara R Castaneda, Lukas Burget, Diego Perez-Tilve, Heather Halem

Am J Physiol Endocrinol Metab· July 2008

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Glucocorticoid inhibition of growth in rats: partial reversal with the full-length ghrelin analog BIM-28125.
Giovanni Tulipano, John E Taylor, Heather A Halem, Rakesh Datta, Jesse Z Dong

Pituitary· April 2008

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Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile.
Mark D Deboer, Xinxia Zhu, Peter R Levasseur, Akio Inui, Zhaoyong Hu, Heather A Halem

Endocrinology· February 2008

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Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia.
Mark D DeBoer, Xin Xia Zhu, Peter Levasseur, Michael M Meguid, Susumu Suzuki, Heather A Halem

Endocrinology· June 2007

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A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain.
Heather A Halem, John E Taylor, Jesse Z Dong, Yeelana Shen, Rakesh Datta

Neuroendocrinology· January 2006

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Novel analogs of ghrelin: physiological and clinical implications.
Heather A Halem, John E Taylor, Jesse Z Dong, Yeelana Shen, Rakesh Datta

Eur J Endocrinol· August 2004

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