Publications by authors named "Heather Harding"

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Protocol for iterative enrichment of integrated sgRNAs via derivative CRISPR-Cas9 libraries from genomic DNA of sorted fixed cells.
Adriana Ordóñez, David Ron, Heather P Harding

STAR Protoc· December 2024

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A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α.
Joanne Tung, Lei Huang, Ginto George, Heather P Harding, David Ron

Elife· July 2024

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Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.
Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa Zyryanova

Proc Natl Acad Sci U S A· April 2024

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The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells.
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding

EMBO J· March 2024

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Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP.
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan

EMBO Mol Med· March 2023

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Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Yahui Yan, Heather P Harding, David Ron

Nat Struct Mol Biol· October 2021

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Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers.
Adriana Ordóñez, Heather P Harding, Stefan J Marciniak, David Ron

Cell Rep· May 2021

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GDF15 mediates the effects of metformin on body weight and energy balance.
Anthony P Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, Heather P Harding

Nature· February 2020

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Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.
Anthony P Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, Heather P Harding

Nature· February 2020

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The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis

Elife· November 2019

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GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.
Satish Patel, Anna Alvarez-Guaita, Audrey Melvin, Debra Rimmington, Alessia Dattilo, Heather P Harding

Cell Metab· March 2019

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Predicting the mutations generated by repair of Cas9-induced double-strand breaks.
Felicity Allen, Luca Crepaldi, Clara Alsinet, Alexander J Strong, Vitalii Kleshchevnikov, Heather Harding

Nat Biotechnol· November 2018

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Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.
Jin A Cho, Ann-Hwee Lee, Barbara Platzer, Benedict C S Cross, Brooke M Gardner, Heather P Harding

Cell Host Microbe· April 2018

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Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Alisa F Zyryanova, Félix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Heather P Harding

Science· March 2018

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A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.
Niko Amin-Wetzel, Reuben A Saunders, Maarten J Kamphuis, Claudia Rato, Steffen Preissler, Heather P Harding

Cell· December 2017

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Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.
Yusuke Sekine, Alisa Zyryanova, Ana Crespillo-Casado, Niko Amin-Wetzel, Heather P Harding

PLoS One· June 2017

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Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
Markus Tschurtschenthaler, Timon E Adolph, Jonathan W Ashcroft, Lukas Niederreiter, Richa Bharti, Heather P Harding

J Exp Med· February 2017

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Dual role of the integrated stress response in medulloblastoma tumorigenesis.
Sarrabeth Stone, Yeung Ho, Xiting Li, Stephanie Jamison, Heather P Harding

Oncotarget· September 2016

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PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis.
Yeung Ho, Xiting Li, Stephanie Jamison, Heather P Harding, Peter J McKinnon

Am J Pathol· July 2016

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Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism.
Masato Miyake, Akitoshi Nomura, Atsushi Ogura, Kenji Takehana, Yoshihiro Kitahara, Heather P Harding

FASEB J· February 2016

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A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly.
Baroj Abdulkarim, Marc Nicolino, Mariana Igoillo-Esteve, Mathilde Daures, Sophie Romero, Heather P Harding

Diabetes· November 2015

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Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker.
Steffen Preissler, Joseph E Chambers, Ana Crespillo-Casado, Edward Avezov, Elena Miranda, Heather P Harding

Elife· October 2015

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Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
Yusuke Sekine, Alisa Zyryanova, Ana Crespillo-Casado, Peter M Fischer, Heather P Harding

Science· May 2015

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G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.
Ruming Chen, Cláudia Rato, Yahui Yan, Ana Crespillo-Casado, Hanna J Clarke, Heather P Harding

Elife· March 2015

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