Publications by authors named "Heather Tye"

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BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.
Michael P Sanderson, Joshua Apgar, Pilar Garin-Chesa, Marco H Hofmann, Dirk Kessler, Heather Tye

Mol Cancer Ther· December 2015

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Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
Hidenori Takahashi, Doris Riether, Alessandra Bartolozzi, Todd Bosanac, Valentina Berger, Heather Tye

J Med Chem· February 2015

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TBAF-catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds.
Frédéric Louërat, Heather Tye, Spencer Napier, Michael Garrigou, Mark Whittaker

Org Biomol Chem· March 2011

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Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT(2C) agonists for the treatment of metabolic disorders.
Heather Tye, Stephan G Mueller, Juergen Prestle, Stefan Scheuerer, Marcus Schindler

Bioorg Med Chem Lett· January 2011

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A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.
Neil Moss, Younggi Choi, Derek Cogan, Adam Flegg, Andreas Kahrs, Heather Tye

Bioorg Med Chem Lett· April 2009

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DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.
Stephen P East, Clara Bantry White, Oliver Barker, Stephanie Barker, James Bennett, Heather Tye

Bioorg Med Chem Lett· February 2009

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Minimisation of palladium content in Suzuki cross-coupling reactions.
Heather Tye, Mark Whittaker, Shailesh Ramdeehul

Comb Chem High Throughput Screen· November 2006

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Microwave-assisted Mannich-type three-component reactions.
Nicholas E Leadbeater, Hanna M Torenius, Heather Tye

Mol Divers· September 2004

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Microwave-promoted organic synthesis using ionic liquids: a mini review.
Nicholas E Leadbeatera, Hanna M Torenius, Heather Tye

Comb Chem High Throughput Screen· August 2004

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Application of statistical 'design of experiments' methods in drug discovery.
Heather Tye

Drug Discov Today· June 2004

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Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction.
Heather Tye, Mark Whittaker

Org Biomol Chem· March 2004

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Rapid cyanation of aryl iodides in water using microwave promotion.
Riina K Arvela, Nicholas E Leadbeater, Hanna M Torenius, Heather Tye

Org Biomol Chem· April 2003

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