Publications by authors named "Helge Prinz"

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10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Jana Waltemate, Igor Ivanov, Jahan B Ghasemi, Elham Aghaee, Constantin Gabriel Daniliuc, Helge Prinz

Bioorg Med Chem Lett· January 2021

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Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor.
Kush Dalal, Helene Morin, Fuqiang Ban, Ashley Shepherd, Michael Fernandez, Helge Prinz

Eur J Med Chem· September 2018

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Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure-activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent.
Atila Basoglu, Simone Dirkmann, Nader Zahedi Golpayegani, Silke Vortherms, Jan Tentrop, Helge Prinz

Eur J Med Chem· July 2017

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N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
Helge Prinz, Ann-Kathrin Ridder, Kirsten Vogel, Konrad J Böhm, Igor Ivanov

J Med Chem· January 2017

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8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties.
Cathrin Lindenschmidt, Dirk Krane, Silke Vortherms, Lars Hilbig, Helge Prinz

Eur J Med Chem· March 2016

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Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase.
Ana Marcu, Uta Schurigt, Klaus Müller, Heidrun Moll, R Luise Krauth-Siegel, Helge Prinz

Eur J Med Chem· January 2016

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Synthesis and structure-activity relationships of lapacho analogues. 2. Modification of the basic naphtho[2,3-b]furan-4,9-dione, redox activation, and suppression of human keratinocyte hyperproliferation by 8-hydroxynaphtho[2,3-b]thiophene-4,9-diones.
Sven Bannwitz, Dirk Krane, Silke Vortherms, Tobias Kalin, Cathrin Lindenschmidt, Helge Prinz

J Med Chem· July 2014

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Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer.
Huifang Li, Mohamed D H Hassona, Nathan A Lack, Peter Axerio-Cilies, Eric Leblanc, Helge Prinz

Mol Cancer Ther· November 2013

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Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.
Dipak Harel, Dirk Schepmann, Helge Prinz, Reto Brun, Thomas J Schmidt

J Med Chem· September 2013

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Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide.
Alexandra Reichstein, Silke Vortherms, Sven Bannwitz, Jan Tentrop, Helge Prinz

J Med Chem· August 2012

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Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Helge Prinz, Peter Schmidt, Konrad J Böhm, Silke Baasner, Klaus Müller

Bioorg Med Chem· July 2011

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N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Helge Prinz, Behfar Chamasmani, Kirsten Vogel, Konrad J Böhm, Babette Aicher

J Med Chem· June 2011

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Synthesis and biological evaluation of novel 10-benzyl-substituted 4,5-dichloro-10H-anthracen-9-ones as inhibitors of keratinocyte hyperproliferation.
Ulrich Kratz, Helge Prinz, Klaus Müller

Eur J Med Chem· November 2010

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Structure-activity relationship studies of acridones as potential antipsoriatic agents. 2. Synthesis and antiproliferative activity of 10-substituted hydroxy-10H-acridin-9-ones against human keratinocyte growth.
Aleksandar Putic, Lambert Stecher, Helge Prinz, Klaus Müller

Eur J Med Chem· November 2010

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Structure-activity relationship studies of acridones as potential antipsoriatic agents. 1. Synthesis and antiproliferative activity of simple N-unsubstituted 10H-acridin-9-ones against human keratinocyte growth.
Aleksandar Putic, Lambert Stecher, Helge Prinz, Klaus Müller

Eur J Med Chem· August 2010

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
Holger C Nickel, Peter Schmidt, Konrad J Böhm, Silke Baasner, Klaus Müller, Helge Prinz

Eur J Med Chem· August 2010

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.
Georg Surkau, Konrad J Böhm, Klaus Müller, Helge Prinz

Eur J Med Chem· August 2010

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Synthesis of 2,6-aceanthrylenedione, a cyclic vinylog of anthraquinone.
Helge Prinz, Konrad J Böhm, Klaus Müller

J Org Chem· June 2010

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10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Helge Prinz, Peter Schmidt, Konrad J Böhm, Silke Baasner, Klaus Müller

J Med Chem· March 2009

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9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity.
Anne Zuse, Helge Prinz, Klaus Müller, Peter Schmidt, Eckhard G Günther

Eur J Pharmacol· December 2007

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Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Anne Zuse, Peter Schmidt, Silke Baasner, Konrad J Böhm, Klaus Müller, Helge Prinz

J Med Chem· November 2007

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9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Anne Zuse, Peter Schmidt, Silke Baasner, Konrad J Böhm, Klaus Müller, Helge Prinz

J Med Chem· December 2006

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Structure and markers of appropriateness, quality and performance of drug treatment over a 1-year period after hospital discharge in a cohort of elderly patients with cardiovascular diseases from Germany.
Sebastian Harder, Philipp Fischer, Markus Krause-Schäfer, Klaus Ostermann, Gottfried Helms, Helge Prinz

Eur J Clin Pharmacol· January 2005

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Marked improvement in left ventricular function and significant reverse left ventricular remodeling within 3 months of cardiac resynchronization therapy in patients with dilated cardiomyopathy.
Reinhard C Funck, Susanne Koelsch, Stefan Waldhans, Helge Prinz, Wolfram Grimm

Pacing Clin Electrophysiol· January 2005

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Chlamydia pneumoniae IgA seropositivity and sudden sensorineural hearing loss.
Anja A Dünne, Anette Wiegand, Helge Prinz, W Slenczka, Jochen A Werner

Otolaryngol Pol· November 2004

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