Publications by authors named "Hubertus Irth"

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Mass spectrometric real-time monitoring of an enzymatic phosphorylation assay using internal standards and data-handling freeware.
Michael Krappmann, Arjen R de Boer, Daniël R W Kool, Hubertus Irth, Thomas Letzel

Rapid Commun Mass Spectrom· April 2016

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Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex.
Danielle S Counotte, Natalia A Goriounova, Milena Moretti, Marek T Smoluch, Hubertus Irth

FASEB J· May 2012

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On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.
David Falck, Jon S B de Vlieger, Martin Giera, Maarten Honing, Hubertus Irth

Anal Bioanal Chem· April 2012

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Studying protein-protein affinity and immobilized ligand-protein affinity interactions using MS-based methods.
Jeroen Kool, Niels Jonker, Hubertus Irth, Wilfried M A Niessen

Anal Bioanal Chem· September 2011

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High-resolution bioactivity profiling of mixtures toward the acetylcholine binding protein using a nanofractionation spotter technology.
Jeroen Kool, Ferry Heus, Gerdien de Kloe, Henk Lingeman, August B Smit, Hubertus Irth

J Biomol Screen· September 2011

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High temperature liquid chromatography hyphenated with ESI-MS and ICP-MS detection for the structural characterization and quantification of halogen containing drug metabolites.
Jon S B de Vlieger, Mark J N Giezen, David Falck, Cornelis Tump, Fred van Heuveln, Hubertus Irth

Anal Chim Acta· July 2011

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Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches.
Cornelius T Martha, Jan-Carel Hoogendoorn, Hubertus Irth, Wilfried M A Niessen

Talanta· May 2011

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Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide.
Lygia Azevedo Marques, Ismail Maada, Frans J J de Kanter, Henk Lingeman, Hubertus Irth

J Pharm Biomed Anal· April 2011

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Recent developments in protein-ligand affinity mass spectrometry.
Niels Jonker, Jeroen Kool, Hubertus Irth, Wilfried M A Niessen

Anal Bioanal Chem· March 2011

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Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures.
Jeroen Kool, Martin Giera, Hubertus Irth, Wilfried M A Niessen

Anal Bioanal Chem· March 2011

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Nanofractionation spotter technology for rapid contactless and high-resolution deposition of LC eluent for further off-line analysis.
Jeroen Kool, Gerdien de Kloe, Arnoud D Denker, Klaas van Altena, Marek Smoluch, Hubertus Irth

Anal Chem· January 2011

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Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands.
Kim Retra, Matthis Geitmann, Jeroen Kool, August B Smit, Iwan J P de Esch, Hubertus Irth

Anal Biochem· December 2010

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Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays.
Ferry Heus, Martin Giera, Gerdien E de Kloe, Dick van Iperen, Joost Buijs, Hubertus Irth

Anal Bioanal Chem· December 2010

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Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine.
Lygia Azevedo Marques, Jeroen Kool, Frans de Kanter, Henk Lingeman, Wilfried Niessen, Hubertus Irth

J Pharm Biomed Anal· November 2010

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Tandem mass spectrometry of silver-adducted ferrocenyl catalyst complexes.
Cornelius T Martha, Willem-Jan van Zeist, F Matthias Bickelhaupt, Hubertus Irth, Wilfried M A Niessen

J Mass Spectrom· November 2010

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Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS.
David Falck, Jon S B de Vlieger, Wilfried M A Niessen, Jeroen Kool, Maarten Honing, Hubertus Irth

Anal Bioanal Chem· October 2010

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Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.
Gerdien E de Kloe, Kim Retra, Matthis Geitmann, Per Källblad, Tariq Nahar, Hubertus Irth

J Med Chem· October 2010

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Target immobilization as a strategy for NMR-based fragment screening: comparison of TINS, STD, and SPR for fragment hit identification.
Masakazu Kobayashi, Kim Retra, Francis Figaroa, Johan G Hollander, Eiso Ab, Hubertus Irth

J Biomol Screen· September 2010

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High throughput screening methodologies classified for major drug target classes according to target signaling pathways.
Jeroen Kool, Henk Lingeman, Wilfried Niessen, Hubertus Irth

Comb Chem High Throughput Screen· July 2010

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Direct Dynamic Protein-Affinity Selection Mass-Spectrometry.
Niels Jonker, Henk Lingeman, Hubertus Irth

Chromatographia· July 2010

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Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment.
Lygia Azevedo Marques, Martin Giera, Frans J J de Kanter, Wilfried M A Niessen, Henk Lingeman, Hubertus Irth

J Pharm Biomed Anal· June 2010

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Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.
Jeroen Kool, Gerdien E de Kloe, Ben Bruyneel, Jon S de Vlieger, Kim Retra, Hubertus Irth

J Med Chem· June 2010

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Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA.
Mark Eggink, Maikel Wijtmans, Ansgar Kretschmer, Jeroen Kool, Henk Lingeman, Hubertus Irth

Anal Bioanal Chem· May 2010

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Structural elucidation of biologically active neomycin N-octyl derivatives in a regioisomeric mixture by means of liquid chromatography/ion trap time-of-flight mass spectrometry.
Martin Giera, Jon S B de Vlieger, Henk Lingeman, Hubertus Irth, Wilfried M A Niessen

Rapid Commun Mass Spectrom· May 2010

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Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.
Jon S B de Vlieger, Ard J Kolkman, Kirsten A M Ampt, Jan N M Commandeur, Nico P E Vermeulen, Hubertus Irth

J Chromatogr B Analyt Technol Biomed Life Sci· March 2010

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