Publications by authors named "Hugues Ouellet"

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An intranasal nanoparticle vaccine elicits protective immunity against Mycobacterium tuberculosis.
K M Samiur Rahman Sefat, Monish Kumar, Stephanie Kehl, Rohan Kulkarni, Ankita Leekha, Hugues Ouellet

Vaccine· September 2024

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-Acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence.
Javier Aguilera, Chitra B Karki, Lin Li, Salvador Vazquez Reyes, Igor Estevao, Hugues Ouellet

J Biol Chem· April 2020

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EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5.
Qi Zhang, Decheng Wang, Guozhong Jiang, Wei Liu, Qing Deng, Hugues Ouellet

Sci Rep· September 2016

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Imaging cytosolic translocation of Mycobacteria with two-photon fluorescence resonance energy transfer microscopy.
Yassel Acosta, Qi Zhang, Arifur Rahaman, Hugues Ouellet, Chuan Xiao

Biomed Opt Express· November 2014

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Genetic and mass spectrometric tools for elucidating the physiological function(s) of cytochrome P450 enzymes from Mycobacterium tuberculosis.
Hugues Ouellet, Eric D Chow, Shenheng Guan, Jeffery S Cox, Alma L Burlingame

Methods Mol Biol· August 2013

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Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion.
Santhosh Sivaramakrishnan, Hugues Ouellet, Hirotoshi Matsumura, Shenheng Guan, Pierre Moënne-Loccoz

J Am Chem Soc· April 2012

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Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
Hugues Ouellet, Jonathan B Johnston, Paul R Ortiz de Montellano

Trends Microbiol· November 2011

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A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid.
Santhosh Sivaramakrishnan, Hugues Ouellet, Jing Du, Kirsty J McLean, Katalin F Medzihradszky

Biochemistry· April 2011

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Structural control of cytochrome P450-catalyzed ω-hydroxylation.
Jonathan B Johnston, Hugues Ouellet, Larissa M Podust, Paul R Ortiz de Montellano

Arch Biochem Biophys· March 2011

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Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1.
Hugues Ouellet, Petrea M Kells, Paul R Ortiz de Montellano, Larissa M Podust

Bioorg Med Chem Lett· January 2011

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Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
Jonathan B Johnston, Hugues Ouellet, Paul R Ortiz de Montellano

J Biol Chem· November 2010

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Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one.
Hugues Ouellet, Shenheng Guan, Jonathan B Johnston, Eric D Chow, Petrea M Kells

Mol Microbiol· August 2010

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Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate.
Petrea M Kells, Hugues Ouellet, Javier Santos-Aberturas, Jesus F Aparicio, Larissa M Podust

Chem Biol· August 2010

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The Mycobacterium tuberculosis cytochrome P450 system.
Hugues Ouellet, Jonathan B Johnston, Paul R Ortiz de Montellano

Arch Biochem Biophys· January 2010

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Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.
Larissa M Podust, Hugues Ouellet, Jens P von Kries, Paul R Ortiz de Montellano

J Biol Chem· September 2009

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Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand.
Yongying Jiang, Michael J Trnka, Katalin F Medzihradszky, Hugues Ouellet, Yongqiang Wang

J Inorg Biochem· March 2009

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Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae.
Shengying Li, Hugues Ouellet, David H Sherman, Larissa M Podust

J Biol Chem· February 2009

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Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide.
Hugues Ouellet, Jérôme Lang, Manon Couture, Paul R Ortiz de Montellano

Biochemistry· February 2009

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Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs.
Hugues Ouellet, Larissa M Podust, Paul R Ortiz de Montellano

J Biol Chem· February 2008

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Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
Larissa M Podust, Jens P von Kries, Ali Nasser Eddine, Youngchang Kim, Liudmila V Yermalitskaya, Hugues Ouellet

Antimicrob Agents Chemother· November 2007

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The roles of Tyr(CD1) and Trp(G8) in Mycobacterium tuberculosis truncated hemoglobin O in ligand binding and on the heme distal site architecture.
Hugues Ouellet, Mario Milani, Marie LaBarre, Martino Bolognesi, Manon Couture

Biochemistry· October 2007

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Reaction of Mycobacterium tuberculosis truncated hemoglobin O with hydrogen peroxide: evidence for peroxidatic activity and formation of protein-based radicals.
Hugues Ouellet, Kalina Ranguelova, Marie Labarre, Jonathan B Wittenberg, Beatrice A Wittenberg

J Biol Chem· March 2007

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Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins.
Mario Milani, Alessandra Pesce, Marco Nardini, Hugues Ouellet, Yannick Ouellet

J Inorg Biochem· January 2005

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Cyanide binding to truncated hemoglobins: a crystallographic and kinetic study.
Mario Milani, Yannick Ouellet, Hugues Ouellet, Michel Guertin, Alberto Boffi

Biochemistry· May 2004

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NO binding induced conformational changes in a truncated hemoglobin from Mycobacterium tuberculosis.
Masahiro Mukai, Yannick Ouellet, Hugues Ouellet, Michel Guertin, Syun-Ru Yeh

Biochemistry· March 2004

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