Publications by authors named "Hui-You Lin"

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promotes invasion and epithelial-to-mesenchymal transition in triple-negative breast cancer by promoting TGF-β/SMAD3 signaling through inhibiting TRIM67-mediated SMAD3 ubiquitination.
Tsung-Ming Chang, Wei-Yu Fang, Hui-Ping Hsu, Pei-Yi Chu, Shih Sheng Jiang, Hui-You Lin

Cancer Biol Ther· December 2025

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Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor-positive breast cancer via regulation of the mTOR pathway.
Hui-Ping Hsu, Pei-Yi Chu, Tsung-Ming Chang, Kuo-Wei Huang, Wen-Chun Hung, Hui-You Lin

Cancer Med· January 2023

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PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.
Tsung-Ming Chang, Pei-Yi Chu, Hui-You Lin, Kuo-Wei Huang, Wen-Chun Hung

J Biomed Sci· November 2022

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c-Myc promotes lymphatic metastasis of pancreatic neuroendocrine tumor through VEGFC upregulation.
Tsung-Ming Chang, Pei-Yi Chu, Wen-Chun Hung, Yan-Shen Shan, Hui-You Lin

Cancer Sci· January 2021

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Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.
Wen-Hsing Lin, Su-Ying Wu, Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Hui-You Lin, Ya-Ling Weng, Ling-Hui Chou

J Med Chem· December 2019

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Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants.
Tsung-Sheng Wu, Wen-Hsing Lin, Hui-Jen Tsai, Ching-Cheng Hsueh, Tsu Hsu, Hui-You Lin

J Med Chem· April 2019

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BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor.
Hui-Jen Tsai, Weir-Torn Jiaang, Neng-Yao Shih, Jonathan A Fletcher, Ming-Jon Lin, Hui-You Lin

Cancer Sci· November 2018

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The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors.
Tsung-Ming Chang, Yan-Shen Shan, Pei-Yi Chu, Shih Sheng Jiang, Wen-Chun Hung, Yu-Lin Chen, Hui-You Lin

Oncotarget· November 2017

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Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors.
Pei-Yi Chu, Shih Sheng Jiang, Yan-Shen Shan, Wen-Chun Hung, Ming-Huang Chen, Hui-You Lin, Yu-Lin Chen

Oncotarget· November 2017

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BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT-Driven Myeloid Leukemia.
Li-Tzong Chen, Chiung-Tong Chen, Weir-Torn Jiaang, Tsai-Yun Chen, Joseph H Butterfield, Hui-You Lin, Sheng-Fung Lin

Mol Cancer Ther· October 2016

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AUY922 effectively targets against activated B cell subtype of diffuse large B-cell lymphoma and low-grade lymphoma cells harboring genetic alteration-associated nuclear factor-κB activation.
Hui-Jen Tsai, Neng-Yao Shih, Sung-Hsin Kuo, Ann-Lii Cheng, Hui-You Lin, Sheng-Fung Lin

Leuk Lymphoma· August 2016

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