Publications by authors named "Ian C Fraser"

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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.
Michael A Letavic, Brad M Savall, Brett D Allison, Leah Aluisio, Jose Ignacio Andres, Ian C Fraser

J Med Chem· June 2017

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Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.
Michael A Letavic, Leah Aluisio, Richard Apodaca, Manoj Bajpai, Ann J Barbier, Ian C Fraser

ACS Med Chem Lett· April 2015

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Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission.
Pascal Bonaventure, Leah Aluisio, James Shoblock, Jamin D Boggs, Ian C Fraser

PLoS One· October 2011

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Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Michael A Letavic, Leah Aluisio, John R Atack, Pascal Bonaventure, Nicholas I Carruthers, Ian C Fraser

Bioorg Med Chem Lett· July 2010

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Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.
Christine Dugovic, Jonathan E Shelton, Leah E Aluisio, Ian C Fraser, Xiaohui Jiang

J Pharmacol Exp Ther· July 2009

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JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition.
Ruggero Galici, Jamin D Boggs, Leah Aluisio, Ian C Fraser, Pascal Bonaventure

Neuropharmacology· June 2009

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In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.
Leah Aluisio, Brian Lord, Ann J Barbier, Ian C Fraser, Sandy J Wilson

Eur J Pharmacol· June 2008

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Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.
John M Keith, Ann J Barbier, Sandy J Wilson, Kirstin Miller, Jamin D Boggs, Ian C Fraser

Bioorg Med Chem Lett· October 2007

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Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
John M Keith, Leslie A Gomez, Ronald L Wolin, Ann J Barbier, Sandy J Wilson, Ian C Fraser

Bioorg Med Chem Lett· May 2007

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Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
John M Keith, Leslie A Gomez, Michael A Letavic, Kiev S Ly, Jill A Jablonowski, Ian C Fraser

Bioorg Med Chem Lett· February 2007

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