Publications by authors named "Ian M Slaymaker"

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Engineering Cas9 for human genome editing.
Ian M Slaymaker, Nicole M Gaudelli

Curr Opin Struct Biol· August 2021

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Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation.
S Haihua Chu, Michael Packer, Holly Rees, Dieter Lam, Yi Yu, Ian M Slaymaker

CRISPR J· April 2021

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High-resolution structure of cas13b and biochemical characterization of RNA targeting and cleavage.
Ian M Slaymaker, Pablo Mesa, Max J Kellner, Soumya Kannan, Edward Brignole

Cell Rep· March 2021

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Base editing: advances and therapeutic opportunities.
Elizabeth M Porto, Alexis C Komor, Ian M Slaymaker, Gene W Yeo

Nat Rev Drug Discov· December 2020

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Directed evolution of adenine base editors with increased activity and therapeutic application.
Nicole M Gaudelli, Dieter K Lam, Holly A Rees, Noris M Solá-Esteves, Luis A Barrera, Ian M Slaymaker

Nat Biotechnol· July 2020

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High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage.
Ian M Slaymaker, Pablo Mesa, Max J Kellner, Soumya Kannan, Edward Brignole

Cell Rep· March 2019

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CRISPR-Cas9 Mediated DNA Unwinding Detected Using Site-Directed Spin Labeling.
Narin S Tangprasertchai, Rosa Di Felice, Xiaojun Zhang, Ian M Slaymaker, Carolina Vazquez Reyes

ACS Chem Biol· June 2017

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Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.
Randall J Platt, Yang Zhou, Ian M Slaymaker, Ashwin S Shetty, Niels R Weisbach

Cell Rep· April 2017

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Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28.
Aaron A Smargon, David B T Cox, Neena K Pyzocha, Kaijie Zheng, Ian M Slaymaker

Mol Cell· February 2017

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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
Omar O Abudayyeh, Jonathan S Gootenberg, Silvana Konermann, Julia Joung, Ian M Slaymaker

Science· August 2016

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Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.
Takashi Yamano, Hiroshi Nishimasu, Bernd Zetsche, Hisato Hirano, Ian M Slaymaker

Cell· May 2016

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Rationally engineered Cas9 nucleases with improved specificity.
Ian M Slaymaker, Linyi Gao, Bernd Zetsche, David A Scott, Winston X Yan

Science· January 2016

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Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.
Bernd Zetsche, Jonathan S Gootenberg, Omar O Abudayyeh, Ian M Slaymaker, Kira S Makarova

Cell· October 2015

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The 1.8-Å crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament.
Yang Fu, Ian M Slaymaker, Junfeng Wang, Ganggang Wang, Xiaojiang S Chen

J Mol Biol· April 2014

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MCM structure and mechanics: what we have learned from archaeal MCM.
Ian M Slaymaker, Xiaojiang S Chen

Subcell Biochem· February 2014

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Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology.
Ian M Slaymaker, Yang Fu, Daniel B Toso, Nimna Ranatunga, Aaron Brewster

Nucleic Acids Res· March 2013

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Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding.
Aaron S Brewster, Ian M Slaymaker, Samir A Afif, Xiaojiang S Chen

BMC Mol Biol· August 2010

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Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.
Ian M Slaymaker, Michael Bracey, Mauro Mileni, Joie Garfunkle, Benjamin F Cravatt

Bioorg Med Chem Lett· November 2008

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