Publications by authors named "Ilan Ifergan"

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Riboflavin concentration within ABCG2-rich extracellular vesicles is a novel marker for multidrug resistance in malignant cells.
Ilan Ifergan, Vicky Goler-Baron, Yehuda G Assaraf

Biochem Biophys Res Commun· February 2009

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Molecular mechanisms of adaptation to folate deficiency.
Ilan Ifergan, Yehuda G Assaraf

Vitam Horm· December 2008

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The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis.
Ilan Ifergan, Gerrit Jansen, Yehuda G Assaraf

J Biol Chem· July 2008

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Sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis.
Ruud Oerlemans, Josefien Vink, Ben A C Dijkmans, Yehuda G Assaraf, Marjolein van Miltenburg, Ilan Ifergan

Ann Rheum Dis· October 2007

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C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
Eran E Bram, Ilan Ifergan, Michal Grimberg, Krzysztof Lemke, Andrzej Skladanowski

Biochem Pharmacol· June 2007

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Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
Eran Bram, Ilan Ifergan, Assaf Shafran, Bluma Berman, Gerrit Jansen

Cancer Chemother Pharmacol· December 2006

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Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
Yehuda G Assaraf, Ilan Ifergan, Wisam N Kadry, Ron Y Pinter

J Theor Biol· June 2006

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Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: transcriptional silencing, inactivating mutations, and allele loss.
Yotam Kaufman, Ilan Ifergan, Lilah Rothem, Gerrit Jansen, Yehuda G Assaraf

Blood· April 2006

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Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.
Ruud Oerlemans, Joost van der Heijden, Josefien Vink, Ben A C Dijkmans, Gertjan J L Kaspers, Ilan Ifergan

Arthritis Rheum· February 2006

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Novel extracellular vesicles mediate an ABCG2-dependent anticancer drug sequestration and resistance.
Ilan Ifergan, George L Scheffer, Yehuda G Assaraf

Cancer Res· December 2005

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ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates.
Assaf Shafran, Ilan Ifergan, Eran Bram, Gerrit Jansen, Ietje Kathmann

Cancer Res· September 2005

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Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation.
Ilan Ifergan, Gerrit Jansen, Yehuda G Assaraf

Mol Pharmacol· April 2005

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Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis.
Gerrit Jansen, Joost van der Heijden, Ruud Oerlemans, Willem F Lems, Ilan Ifergan

Arthritis Rheum· July 2004

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Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis.
Ilan Ifergan, Assaf Shafran, Gerrit Jansen, Jan Hendrik Hooijberg, George L Scheffer

J Biol Chem· June 2004

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Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
Yotam Kaufman, Stavit Drori, Peter D Cole, Barton A Kamen, Jenny Sirota, Ilan Ifergan

Cancer· February 2004

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Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity.
Ilan Ifergan, Issac Meller, Josefin Issakov, Yehuda G Assaraf

Cancer· November 2003

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Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells.
Yehuda G Assaraf, Lilah Rothem, Jan Hendrik Hooijberg, Michal Stark, Ilan Ifergan

J Biol Chem· February 2003

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Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines.
Lilah Rothem, Ilan Ifergan, Yotam Kaufman, David G Priest, Gerrit Jansen

Biochem J· November 2002

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