Publications by authors named "Isaac Forquer"

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Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity.
Dmitri Rozanov, Anton Cheltsov, Aaron Nilsen, Christopher Boniface, Isaac Forquer

PLoS One· November 2019

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Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance.
Amber E Bannon, Jason Kent, Isaac Forquer, Ajia Town, Lillian R Klug

Clin Cancer Res· November 2017

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Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.
Lisa Frueh, Yuexin Li, Michael W Mather, Qigui Li, Sovitj Pou, Isaac P Forquer

ACS Infect Dis· October 2017

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Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.
Allison M Stickles, Martin J Smilkstein, Joanne M Morrisey, Yuexin Li, Isaac P Forquer

Antimicrob Agents Chemother· August 2016

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Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs.
Diana Ortiz, Isaac Forquer, Jan Boitz, Radika Soysa, Carolyn Elya

Antimicrob Agents Chemother· August 2016

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Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone.
Lauren A Lawres, Aprajita Garg, Vidya Kumar, Igor Bruzual, Isaac P Forquer

J Exp Med· June 2016

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ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.
Galen P Miley, Sovitj Pou, Rolf Winter, Aaron Nilsen, Yuexin Li, Isaac P Forquer

Antimicrob Agents Chemother· September 2015

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Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.
Allison M Stickles, Li-Min Ting, Joanne M Morrisey, Yuexin Li, Michael W Mather, Isaac P Forquer

Am J Trop Med Hyg· June 2015

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Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.
Allison M Stickles, Mariana Justino de Almeida, Joanne M Morrisey, Kayla A Sheridan, Isaac P Forquer

Antimicrob Agents Chemother· April 2015

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Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.
Aaron Nilsen, Galen P Miley, Isaac P Forquer, Michael W Mather, Kasiram Katneni

J Med Chem· May 2014

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Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.
Radika Soysa, Zachary N Wilson, Johannes Elferich, Isaac Forquer, Ujwal Shinde

J Biol Chem· October 2013

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Quinolone-3-diarylethers: a new class of antimalarial drug.
Aaron Nilsen, Alexis N LaCrue, Karen L White, Isaac P Forquer, Richard M Cross

Sci Transl Med· March 2013

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Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis.
J Stone Doggett, Aaron Nilsen, Isaac Forquer, Keith W Wegmann, Lorraine Jones-Brando

Proc Natl Acad Sci U S A· September 2012

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Loss of a conserved tyrosine residue of cytochrome b induces reactive oxygen species production by cytochrome bc1.
Dong-Woo Lee, Nur Selamoglu, Pascal Lanciano, Jason W Cooley, Isaac Forquer

J Biol Chem· May 2011

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Chemical genetics of Plasmodium falciparum.
W Armand Guiguemde, Anang A Shelat, David Bouck, Sandra Duffy, Gregory J Crowther, Isaac Forquer

Nature· May 2010

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A drug-selected Plasmodium falciparum lacking the need for conventional electron transport.
Martin J Smilkstein, Isaac Forquer, Atsuko Kanazawa, Jane Xu Kelly, Rolf W Winter

Mol Biochem Parasitol· May 2008

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Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex.
Isaac Forquer, Raul Covian, Michael K Bowman, Bernard L Trumpower, David M Kramer

J Biol Chem· December 2006

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