Publications by authors named "JS Scott"

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Generation of a potent & selective series of IRAK4 inhibitors based on a structure based, hybridization approach.
Ina Terstiege, Anna Aagaard, Kristina Berggren, James Bird, Iain A Cumming, James S Scott

Bioorg Med Chem· December 2025

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Microplastics as environmental modifiers of lung disease.
Emmanouela Epeslidou, Julia S Scott, Bim de Klein, Jeremy Tan Cudia, Barbro Melgert

EMBO Mol Med· December 2025

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Lessons learned in linking PROTACs from discovery to the clinic.
Andy Pike, Esther C Y Lee, Iacovos N Michaelides, Markus Schade, Ankit Sharma, James S Scott

Nat Rev Chem· December 2025

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Correction: Emerging roles of cohesin-STAG2 in cancer.
Julia S Scott, Loubna Al Ayadi, Emmanouela Epeslidou, Roan H van Scheppingen, Anna Mukha

Oncogene· August 2025

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The application of mechanistic absorption, distribution, metabolism and excretion studies and physiologically-based pharmacokinetic modeling in the discovery of the next-generation oral selective estrogen receptor degrader camizestrant to achieve an acceptable human pharmacokinetic profile.
Eric T Gangl, Roshini Markandu, Pradeep Sharma, Andy Sykes, Petar Pop-Damkov, James S Scott

Drug Metab Dispos· August 2025

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Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1.
Lior Soday, Chotima Seripracharat, Janine L Gray, André F S Luz, Ryan T Howard, James S Scott

ACS Chem Biol· July 2025

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Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice.
Jess C Hercus, Daniel Alejandro Salcedo Rubio, Maria Elisa Osorio Nieto, Cheayeong Keum, Qi Wang, Jordan S Scott

Mol Hum Reprod· April 2025

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Property-based optimisation of PROTACs.
James S Scott, Iacovos N Michaelides, Markus Schade

RSC Med Chem· February 2025

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Emerging roles of cohesin-STAG2 in cancer.
Julia S Scott, Loubna Al Ayadi, Emmanouela Epeslidou, Roan H van Scheppingen, Anna Mukha

Oncogene· February 2025

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American Society for Gastrointestinal Endoscopy guideline on the diagnosis and management of GERD: summary and recommendations.

Gastrointest Endosc· February 2025

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American Society for Gastrointestinal Endoscopy guideline on the diagnosis and management of GERD: methodology and review of evidence.

VideoGIE· February 2025

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Structural and Physicochemical Features of Oral PROTACs.
Markus Schade, James S Scott, Thomas G Hayhow, Andy Pike, Ina Terstiege

J Med Chem· August 2024

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Discovery and Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
James M Smith, Bernard Barlaam, David Beattie, Lauren Bradshaw, Ho Man Chan, Scott Lamont, James S Scott

J Med Chem· August 2024

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Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.
Sharan K Bagal, Peter C Astles, Coura Diène, Argyrides Argyrou, Claire Crafter, Scott Lamont, James S Scott

J Med Chem· July 2024

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Role of mucositis in predicting gut microbiota composition in people with cancer.
Jacqui S Scott, Anna Li, Hannah R Wardill

Curr Opin Support Palliat Care· June 2024

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Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC.
Thomas G Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L Braybrooke, Scott Martin, James S Scott

Commun Biol· May 2024

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Selective estrogen receptor degraders (SERDs) and covalent antagonists (SERCAs): a patent review (July 2021-December 2023).
James S Scott, Teresa C M Klinowska

Expert Opin Ther Pat· May 2024

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Reversible O-H Bond Activation by Tripodal tris(Nitroxide) Aluminum and Gallium Complexes.
Joseph S Scott, Mika L Maenaga, Audra J Woodside, Vivian W Guo, Alex R Cheriel

Inorg Chem· March 2024

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Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Scott Lamont, James S Scott

J Med Chem· March 2024

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Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech.
Aditi Pradhan, Hayley Mounford, Jessica Peixinho, Edward Rea, Emmanouela Epeslidou, Julia S Scott

Cell Mol Life Sci· March 2024

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Fatty acid elongation regulates mitochondrial β-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels.
Julia S Scott, Lake-Ee Quek, Andrew J Hoy, Johannes V Swinnen, Zeyad D Nassar

Biochem Biophys Res Commun· January 2024

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The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance.
Mandy Lawson, Natalie Cureton, Susana Ros, Azadeh Cheraghchi-Bashi, Jelena Urosevic, James S Scott

Cancer Res· December 2023

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Combining Donor Strength and Oxidative Stability in Scorpionates: A Strongly Donating Fluorinated Mesoionic Tris(imidazol-5-ylidene)borate Ligand.
Joseph S Scott, Joseph E Schneider, Eyob G Tewelde, Joel G Gardner, Sophie W Anferov

Inorg Chem· December 2023

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Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome.
Jan Philipp Menzel, Reuben S E Young, Aurélie H Benfield, Julia S Scott, Puttandon Wongsomboon

Nat Commun· July 2023

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The effect of geographic origin and destination on congenital heart disease outcomes: a retrospective cohort study.
Spencer M Millen, Cara H Olsen, Ryan P Flanagan, John S Scott, Craig P Dobson

BMC Cardiovasc Disord· February 2023

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