Publications by authors named "Jacob Brenner"

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Equip your vehicle for the right terrain: Using features of local pathology to guide engineering of targeted drug delivery systems.
Taylor V Brysgel, Jing Liu, Elizabeth D Hood, Jacob S Brenner, Vladimir R Muzykantov

J Control Release· January 2026

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Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity.
Nicolas Marzolini, Taylor V Brysgel, Ryan J Rahman, Eno-Obong Essien, Saw Y Nwe, Jacob S Brenner

bioRxiv· October 2025

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Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage.
Sahily Reyes-Esteves, Aparajeeta Majumder, Nicolas Marzolini, Marco E Zamora, Soomin Jeong, Jacob S Brenner

J Neuroinflammation· October 2025

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Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.
Serena Omo-Lamai, Yufei Wang, Manthan N Patel, Aleksa Milosavljevic, Daniel Zuschlag, Jacob S Brenner

Nat Nanotechnol· September 2025

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Preparation and Characterization of Lipid Nanoparticles Co-loaded With DNA and Nitro-Oleic Acid.
Manthan N Patel, Sachchidanand Tiwari, Jacob S Brenner

Bio Protoc· September 2025

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TSC2 loss in neural progenitor cells suppresses mRNA translation of neurodevelopmental genes.
Pauline Martin, Krzysztof J Szkop, Francis Robert, Srirupa Bhattacharyya, Roberta L Beauchamp, Jacob Brenner

Brain· August 2025

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A percolation phase transition controls complement protein coating of surfaces.
Zhicheng Wang, Sahil Kulkarni, Jia Nong, Marco Zamora, Alireza Ebrahimimojarad, Jacob S Brenner

Cell· July 2025

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Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.
Vladimir V Shuvaev, Ying K Tam, Benjamin W Lee, Jacob W Myerson, Alan Herbst, Jacob S Brenner

Proc Natl Acad Sci U S A· July 2025

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Use of a Shoulder-Mounted Wearable Sensor Prototype Designed to Detect Opioid-Related Overdose: A Qualitative User Experience Study.
Alexis M Roth, Ally K D'Angelo, David Gordon, Benjamin Cocchiaro, Anush Lingamoorthy, Jacob S Brenner

J Med Internet Res· July 2025

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Perspective: Advancing safe and effective DNA therapeutics using bioactive lipid nanoparticles.
Manthan N Patel, Sachchidanand Tiwari, Jacob S Brenner

Mol Ther· June 2025

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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
Nicholas J Tursi, Sachchidanand Tiwari, Nicole Bedanova, Toshitha Kannan, Elizabeth Parzych, Jacob S Brenner

Cell Rep Med· April 2025

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Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage.
Sahily Reyes-Esteves, Aparajeeta Majumder, Nicolas Marzolini, Marco Zamora, Yufei Wang, Jacob Brenner

Res Sq· April 2025

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An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy.
Zhen Zhang, Chen Xu, Ningqiang Gong, Guangchao Qing, Yuxuan Zhang, Jacob S Brenner

J Control Release· March 2025

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Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude.
Jia Nong, Xijing Gong, Quang Minh Dang, Sachchidanand Tiwari, Manthan Patel, Jacob S Brenner

bioRxiv· February 2025

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Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation.
Michael H Zaleski, Liam S Chase, Elizabeth D Hood, Zhicheng Wang, Jia Nong, Jacob S Brenner

Adv Mater· February 2025

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Biomechanical and Functional Features of the Carrier Erythrocytes Prolonging Circulation Time of Biotherapeutic Targeted to Glycophorin A.
Alina D Peshkova, Taylor V Brysgel, Parth Mody, Jia Nong, Zhicheng Wang, Jacob S Brenner

Bioconjug Chem· February 2025

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Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids.
Manthan N Patel, Sachchidanand Tiwari, Yufei Wang, Sarah O'Neill, Jichuan Wu, Jacob S Brenner

Nat Biotechnol· February 2025

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Neutrophil-avid nanocarrier uptake by STAT3 dominant-negative hyper-IgE syndrome patient neutrophils.
Kathryn M Rubey, Alexandra Freeman, Alexander R Mukhitov, Andrew J Paris, Susan M Lin, Jacob S Brenner

Life Sci Alliance· November 2024

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Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy.
Michael H Zaleski, Serena Omo-Lamai, Jia Nong, Liam S Chase, Jacob W Myerson, Jacob S Brenner

J Control Release· October 2024

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A percolation-type criticality threshold controls immune protein coating of surfaces.
Zhicheng Wang, Sahil Kulkarni, Jia Nong, Marco Zamora, Alireza Ebrahimimojarad, Jacob S Brenner

bioRxiv· October 2024

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Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System.
Marco E Zamora, Eno-Obong Essien, Kartik Bhamidipati, Aditi Murthy, Jing Liu, Jacob S Brenner

ACS Nano· August 2024

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loss in neural progenitor cells suppresses translation of ASD/NDD-associated transcripts in an mTORC1- and MNK1/2-reversible fashion.
Pauline Martin, Krzysztof J Szkop, Francis Robert, Srirupa Bhattacharyya, Roberta L Beauchamp, Jacob Brenner

bioRxiv· July 2024

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Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions.
Thomas Anchordoquy, Natalie Artzi, Irina V Balyasnikova, Yechezkel Barenholz, Ninh M La-Beck, Jacob S Brenner

ACS Nano· June 2024

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Targeting of nanoparticles to the cerebral vasculature after traumatic brain injury.
Serena Omo-Lamai, Jia Nong, Krupa Savalia, Brian J Kelley, Jichuan Wu, Jacob S Brenner

PLoS One· June 2024

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Enabling non-viral DNA delivery using lipid nanoparticles co-loaded with endogenous anti-inflammatory lipids.
Manthan N Patel, Sachchidanand Tiwari, Yufei Wang, Sarah O'Neill, Jichuan Wu, Jacob S Brenner

bioRxiv· June 2024

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