Publications by authors named "Jacob Janey"

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Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist.
Yong-Li Zhong, Jeffrey C Moore, Michael Shevlin, C Scott Shultz, Birgit Kosjek, Jacob M Janey

J Org Chem· February 2022

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Bayesian reaction optimization as a tool for chemical synthesis.
Benjamin J Shields, Jason Stevens, Jun Li, Marvin Parasram, Farhan Damani, Jacob M Janey

Nature· February 2021

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Development of a Platform for Near-Infrared Photoredox Catalysis.
Benjamin D Ravetz, Nicholas E S Tay, Candice L Joe, Melda Sezen-Edmonds, Michael A Schmidt, Jacob M Janey

ACS Cent Sci· November 2020

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Direct Lewis Acid Catalyzed Conversion of Enantioenriched N-Acyloxazolidinones to Chiral Esters, Amides, and Acids.
Jason M Stevens, Ana Cristina Parra-Rivera, Darryl D Dixon, Gregory L Beutner, Albert J DelMonte, Jacob M Janey

J Org Chem· December 2018

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Enantioselective Synthesis of a γ-Secretase Modulator via Vinylogous Dynamic Kinetic Resolution.
Neil A Strotman, Antonio Ramirez, Eric M Simmons, Omid Soltani, Andrew T Parsons, Jacob M Janey

J Org Chem· September 2018

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Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes.
Gregory Beutner, Ronald Carrasquillo, Peng Geng, Yi Hsiao, Eric C Huang, Jacob Janey

Org Lett· July 2018

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Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction.
Feng Xu, Birgit Kosjek, Fabien L Cabirol, Haibin Chen, Richard Desmond, Jacob M Janey

Angew Chem Int Ed Engl· June 2018

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Zinc Acetate-Promoted Buchwald-Hartwig Couplings of Heteroaromatic Amines.
Rajaram Ayothiraman, Sundaramurthy Rangaswamy, Prantik Maity, Eric M Simmons, Gregory L Beutner, Jacob Janey

J Org Chem· July 2017

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High-Throughput Automation in Chemical Process Development.
Joshua A Selekman, Jun Qiu, Kristy Tran, Jason Stevens, Victor Rosso, Jacob Janey

Annu Rev Chem Biomol Eng· June 2017

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Development of a Diastereoselective Phosphorylation of a Complex Nucleoside via Dynamic Kinetic Resolution.
Kristy Tran, Gregory L Beutner, Michael Schmidt, Jacob Janey, Ke Chen

J Org Chem· May 2015

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Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis strategy.
Jongrock Kong, Cheng-yi Chen, Jaume Balsells-Padros, Yang Cao, Robert F Dunn, Jacob Janey

J Org Chem· April 2012

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Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.
Christopher K Savile, Jacob M Janey, Emily C Mundorff, Jeffrey C Moore, Sarena Tam

Science· July 2010

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A practical synthesis of 5-lipoxygenase inhibitor MK-0633.
Francis Gosselin, Robert A Britton, Ian W Davies, Sarah J Dolman, Danny Gauvreau, Jacob Janey

J Org Chem· June 2010

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Remote electronic control in the regioselective reduction of succinimides: a practical, scalable synthesis of Ep4 antagonist MF-310.
Carmela Molinaro, Danny Gauvreau, Gregory Hughes, Stephen Lau, Sophie Lauzon, Jacob Janey

J Org Chem· September 2009

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Raney-Co mediated reductive cyclization of an alpha,beta-unsaturated nitrile.
Jacob M Janey, Charles J Orella, Eugenia Njolito, Jenny M Baxter, Jonathan D Rosen

J Org Chem· April 2008

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Proline-catalyzed, asymmetric mannich reactions in the synthesis of a DPP-IV inhibitor.
Jacob M Janey, Yi Hsiao, Joseph D Armstrong

J Org Chem· January 2006

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Recent advances in catalytic, enantioselective alpha aminations and alpha oxygenations of carbonyl compounds.
Jacob M Janey

Angew Chem Int Ed Engl· July 2005

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Chiral Salen-Aluminum Complexes as Catalysts for Enantioselective Aldol Reactions of Aldehydes and 5-Alkoxyoxazoles: An Efficient Approach to the Asymmetric Synthesis of syn and anti beta-Hydroxy-alpha-amino Acid Derivatives Financial support has been provided by the National Institutes of Health (GM 43912-11 and GM 33328-18).
David A. Evans, Jacob M. Janey, Nabi Magomedov, Jason S. Tedrow

Angew Chem Int Ed Engl· May 2001

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1-Amino-3-siloxy-1,3-butadienes: Highly Reactive Dienes for the Diels-Alder Reaction.
Sergey A. Kozmin, Jacob M. Janey, Viresh H. Rawal

J Org Chem· April 1999

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Chiral C -Symmetric Cu Complexes as Catalysts for Enantioselective Hetero-Diels-Alder Reactions.
David A Evans, Edward J Olhava, Jeffrey S Johnson, Jacob M Janey

Angew Chem Int Ed Engl· December 1998

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