Publications by authors named "Jacob Kaizerman"

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Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Zhihong Li, Xianghong Wang, John Eksterowicz, Michael W Gribble, Grace Q Alba, Jacob Kaizerman

J Med Chem· April 2014

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Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.
Matthew L Brown, Wade Aaron, Richard J Austin, Angela Chong, Tom Huang, Jacob A Kaizerman

Bioorg Med Chem Lett· September 2011

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Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.
Daqing Sun, Zhulun Wang, Seb Caille, Michael DeGraffenreid, Felix Gonzalez-Lopez de Turiso, Jacob Kaizerman

Bioorg Med Chem Lett· January 2011

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Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.
Jacob A Kaizerman, Wade Aaron, Songzhu An, Richard Austin, Matt Brown

Bioorg Med Chem Lett· August 2010

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Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.
Brian S Lucas, Wade Aaron, Songzhu An, Richard J Austin, Matthew Brown, Jacob A Kaizerman

Bioorg Med Chem Lett· June 2010

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Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Dustin L McMinn, Yosup Rew, Athena Sudom, Seb Caille, Michael Degraffenreid, Jacob Kaizerman

Bioorg Med Chem Lett· March 2009

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Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
Jian-Xin Duan, Hailong Jiao, Jacob Kaizerman, Timothy Stanton, James W Evans

J Med Chem· April 2008

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An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane beta-keto esters.
Michael R DeGraffenreid, Sarah Bennett, Sebastien Caille, Felix Gonzalez-Lopez de Turiso, Randall W Hungate, Jacob A Kaizerman

J Org Chem· September 2007

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DNA binding ligands with improved in vitro and in vivo potency against drug-resistant Staphylococcus aureus.
Wenhao Hu, Roland W Bürli, Jacob A Kaizerman, Kirk W Johnson, Matthew I Gross

J Med Chem· August 2004

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DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids.
Roland W Bürli, Jacob A Kaizerman, Jian-Xin Duan, Peter Jones, Kirk W Johnson

Bioorg Med Chem Lett· May 2004

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives.
Roland W Bürli, Dustin McMinn, Jacob A Kaizerman, Wenhao Hu, Yigong Ge

Bioorg Med Chem Lett· March 2004

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives.
Roland W Bürli, Peter Jones, Dustin McMinn, Quan Le, Jian-Xin Duan, Jacob A Kaizerman

Bioorg Med Chem Lett· March 2004

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DNA binding ligands targeting drug-resistant bacteria: structure, activity, and pharmacology.
Jacob A Kaizerman, Matthew I Gross, Yigong Ge, Sarah White, Wenhao Hu

J Med Chem· August 2003

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DNA binding ligands with excellent antibiotic potency against drug-resistant gram-positive bacteria.
Roland W Bürli, Yigong Ge, Sarah White, Eldon E Baird, Sofia M Touami, Jacob A Kaizerman

Bioorg Med Chem Lett· September 2002

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