Publications by authors named "Dustin McMinn"

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Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity.
Eric Lowe, Janet L Anderl, David Bade, Cristina Delgado-Martin, Chengguo Dong, Dustin McMinn

J Pharmacol Exp Ther· August 2025

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Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome.
Pavla Fajtova, Brianna M Hurysz, Yukiko Miyamoto, Mateus Sá M Serafim, Zhenze Jiang, Dustin L McMinn

Protein Sci· December 2024

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Global signal peptide profiling reveals principles of selective Sec61 inhibition.
Nicole A Wenzell, Brian B Tuch, Dustin L McMinn, Matthew J Lyons, Christopher J Kirk

Nat Chem Biol· September 2024

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Signal peptide mimicry primes Sec61 for client-selective inhibition.
Shahid Rehan, Dale Tranter, Phillip P Sharp, Gregory B Craven, Eric Lowe, Dustin McMinn

Nat Chem Biol· September 2023

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Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses.
Tony Muchamuel, R Andrea Fan, Janet L Anderl, Darrin J Bomba, Henry W B Johnson, Dustin L McMinn

Front Immunol· March 2023

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Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.
Lauren K Meyer, Cristina Delgado-Martin, Phillip P Sharp, Benjamin J Huang, Dustin McMinn

Br J Haematol· July 2022

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Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome.
Ying Fang, Henry Johnson, Janet L Anderl, Tony Muchamuel, Dustin McMinn

Drug Metab Dispos· September 2021

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Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).
Henry W B Johnson, Eric Lowe, Janet L Anderl, Andrea Fan, Tony Muchamuel, Dustin L McMinn

J Med Chem· December 2018

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Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.
Henry W B Johnson, Janet L Anderl, Erin K Bradley, John Bui, Jeffrey Jones, Dustin McMinn

ACS Med Chem Lett· April 2017

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Synthesis, in Vitro Covalent Binding Evaluation, and Metabolism of (14)C-Labeled Inhibitors of 11β-HSD1.
Daqing Sun, Qiuping Ye, Xuelei Yan, Yosup Rew, Peter Fan, Dustin L McMinn

ACS Med Chem Lett· November 2014

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Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.
Ming Yu, Yingcai Wang, Jiang Zhu, Michael D Bartberger, Jude Canon, Dustin McMinn

ACS Med Chem Lett· August 2014

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Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Zhihong Li, Xianghong Wang, John Eksterowicz, Michael W Gribble, Grace Q Alba, Dustin L McMinn

J Med Chem· April 2014

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Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.
Brian M Fox, Kazuyuki Sugimoto, Kiyosei Iio, Atsuhito Yoshida, Jian Ken Zhang, Dustin McMinn

J Med Chem· April 2014

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Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.
Ana Z Gonzalez, John Eksterowicz, Michael D Bartberger, Hilary P Beck, Jude Canon, Dustin L McMinn

J Med Chem· March 2014

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Rational design and binding mode duality of MDM2-p53 inhibitors.
Felix Gonzalez-Lopez de Turiso, Daqing Sun, Yosup Rew, Michael D Bartberger, Hilary P Beck, Dustin McMinn

J Med Chem· May 2013

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Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors.
Yosup Rew, Michael DeGraffenreid, Xiao He, Juan C Jaen, Dustin L McMinn

Bioorg Med Chem Lett· June 2012

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Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.
Matthew L Brown, Wade Aaron, Richard J Austin, Angela Chong, Tom Huang, Dustin L McMinn

Bioorg Med Chem Lett· September 2011

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Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.
Daqing Sun, Zhulun Wang, Seb Caille, Michael DeGraffenreid, Felix Gonzalez-Lopez de Turiso, Dustin L McMinn

Bioorg Med Chem Lett· January 2011

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The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.
Xuelei Yan, Zhulun Wang, Athena Sudom, Mario Cardozo, Michael DeGraffenreid, Dustin McMinn

Bioorg Med Chem Lett· December 2010

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Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.
Jacob A Kaizerman, Wade Aaron, Songzhu An, Richard Austin, Matt Brown, Dustin L McMinn

Bioorg Med Chem Lett· August 2010

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Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.
Brian S Lucas, Wade Aaron, Songzhu An, Richard J Austin, Matthew Brown, Dustin L McMinn

Bioorg Med Chem Lett· June 2010

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Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Dustin L McMinn, Yosup Rew, Athena Sudom, Seb Caille, Michael Degraffenreid

Bioorg Med Chem Lett· March 2009

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Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.
Yosup Rew, Dustin L McMinn, Zhulun Wang, Xiao He, Randall W Hungate

Bioorg Med Chem Lett· March 2009

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Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.
Lisa D Julian, Zhulun Wang, Tracy Bostick, Seb Caille, Rebekah Choi, Dustin McMinn

J Med Chem· July 2008

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An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane beta-keto esters.
Michael R DeGraffenreid, Sarah Bennett, Sebastien Caille, Felix Gonzalez-Lopez de Turiso, Randall W Hungate, Dustin L McMinn

J Org Chem· September 2007

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