Publications by authors named "Jacquelynn J Cook"

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Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193.
Eric D Hostetler, Hong Fan, Aniket D Joshi, Zhizhen Zeng, Waisi Eng, Jacquelynn J Cook

Mol Imaging Biol· August 2016

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Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.
Melissa Egbertson, Georgia B McGaughey, Steven M Pitzenberger, Shaun R Stauffer, Craig A Coburn, Jacquelynn J Cook

Bioorg Med Chem Lett· November 2015

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Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys.
Christian Fischer, Susan L Zultanski, Hua Zhou, Joey L Methot, Sanjiv Shah, Jacquelynn J Cook

Bioorg Med Chem Lett· September 2015

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The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey.
Donnie Eddins, Terence G Hamill, Vanita Puri, Christopher E Cannon, Jeffrey A Vivian, Jacquelynn J Cook

Psychopharmacology (Berl)· February 2014

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In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232.
Eric D Hostetler, Aniket D Joshi, Sandra Sanabria-Bohórquez, Hong Fan, Zhizhen Zeng, Jacquelynn J Cook

J Pharmacol Exp Ther· November 2013

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[(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor.
Ian M Bell, Steven N Gallicchio, Craig A Stump, Joseph G Bruno, Hong Fan, Jacquelynn J Cook

ACS Med Chem Lett· September 2013

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Evaluation of [¹⁸F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human.
Eric D Hostetler, Sandra Sanabria-Bohórquez, Waisi Eng, Aniket D Joshi, Shailendra Patel, Jacquelynn J Cook

Neuroimage· March 2013

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Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease.
Guoxin Wu, Sethu Sankaranarayanan, Jacky Wong, Katherine Tugusheva, Maria S Michener, Jacquelynn J Cook

J Neurosci Res· December 2012

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Quantification of the glycine transporter 1 in rhesus monkey brain using [18F]MK-6577 and a model-based input function.
Sandra M Sanabria-Bohórquez, Aniket D Joshi, Marie Holahan, Lori Daneker, Kerry Riffel, Jacquelynn J Cook

Neuroimage· February 2012

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[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey.
Eric D Hostetler, Sandra Sanabria-Bohórquez, Hong Fan, Zhizhen Zeng, Linda Gammage, Jacquelynn J Cook

Nucl Med Biol· November 2011

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Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328.
Scott T Harrison, James Mulhearn, Scott E Wolkenberg, Patricia J Miller, Stacey S O'Malley, Jacquelynn J Cook

ACS Med Chem Lett· July 2011

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P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.
Richard C A Isaacs, Christina L Newton, Kellie J Cutrona, Swati P Mercer, Bruce D Dorsey, Jacquelynn J Cook

Bioorg Med Chem Lett· March 2011

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Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.
Richard C A Isaacs, Christina L Newton, Kellie J Cutrona, Swati P Mercer, Linda S Payne, Jacquelynn J Cook

Bioorg Med Chem Lett· March 2011

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Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor.
Eric D Hostetler, Sandra Sanabria-Bohórquez, Hong Fan, Zhizhen Zeng, Liza Gantert, Jacquelynn J Cook

Neuroimage· February 2011

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Modeling effect of a γ-secretase inhibitor on amyloid-β dynamics reveals significant role of an amyloid clearance mechanism.
Raibatak Das, Robert B Nachbar, Leah Edelstein-Keshet, Jeffrey S Saltzman, Matthew C Wiener, Jacquelynn J Cook

Bull Math Biol· January 2011

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Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.
Jacquelynn J Cook, Kristin R Wildsmith, David B Gilberto, Marie A Holahan, Gene G Kinney

J Neurosci· May 2010

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Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist.
Christopher A Salvatore, Eric L Moore, Amy Calamari, Jacquelynn J Cook, Maria S Michener

J Pharmacol Exp Ther· April 2010

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Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometry.
Cloud P Paweletz, Matthew C Wiener, Andrey Y Bondarenko, Nathan A Yates, Qinghua Song, Jacquelynn J Cook

J Proteome Res· March 2010

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Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors.
Hong Zhu, Mary B Young, Philippe G Nantermet, Samuel L Graham, Dennis Colussi, Jacquelynn J Cook

Bioorg Med Chem Lett· March 2010

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Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys.
Cuyue Tang, Yuhsin Kuo, Nicole T Pudvah, Joan D Ellis, Maria S Michener, Jacquelynn J Cook

Biochem Pharmacol· September 2009

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fMRI investigation of the effect of local and systemic lidocaine on noxious electrical stimulation-induced activation in spinal cord.
Fuqiang Zhao, Mangay Williams, Denise C Welsh, Xiangjun Meng, Amy Ritter, Jacquelynn J Cook

Pain· September 2009

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A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis.
Matthew Walker, Barry R Campbell, Karim Azer, Christopher Tong, Kaijie Fang, Jacquelynn J Cook

Atherosclerosis· May 2009

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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
Sethu Sankaranarayanan, Marie A Holahan, Dennis Colussi, Ming-Chih Crouthamel, Viswanath Devanarayan, Jacquelynn J Cook

J Pharmacol Exp Ther· January 2009

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Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.
Philippe G Nantermet, Hemaka A Rajapakse, Mathew G Stanton, Shaun R Stauffer, James C Barrow, Jacquelynn J Cook

ChemMedChem· January 2009

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Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects.
Guoxin Wu, Sethu Sankaranarayanan, Kate Tugusheva, Jason Kahana, Guy Seabrook, Jacquelynn J Cook

Clin Biochem· August 2008

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