Publications by authors named "Jacques Roberge"

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A FtsZ inhibitor-acinetobactin conjugate with enhanced cellular uptake in Acinetobacter baumannii acts synergistically in combination with PBP3-targeting antibiotics.
Eric J Bryan, Zoltan Szekely, Yuxuan Wang, Huizhou Fan, Lucile Moynié, Jacques Y Roberge

PLoS One· October 2025

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Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site.
John E McLaughlin, Michael J Rudolph, Arkajyoti Dutta, Xiao-Ping Li, Anastasiia M Tsymbal, Jacques Y Roberge

J Biol Chem· March 2025

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BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells.
Ashley Toussaint, Manohar Singh, Guoquiang Wang, Monica Driscoll, Vrushank Bhatt, Jacques Roberge

Res Sq· September 2024

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Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2.
Michael J Rudolph, Anastasiia M Tsymbal, Arkajyoti Dutta, Simon A Davis, Benjamin Algava, Jacques Y Roberge

ACS Infect Dis· August 2024

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Correction to "Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials".
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Jacques Y Roberge

J Med Chem· July 2024

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Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Jacques Y Roberge

J Med Chem· March 2024

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Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Michael J Rudolph, Arkajyoti Dutta, Anastasiia M Tsymbal, John E McLaughlin, Yang Chen, Jacques Y Roberge

Bioorg Med Chem· February 2024

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A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens.
Eric J Bryan, Qi Qiao, Yuxuan Wang, Jacques Y Roberge, Edmond J LaVoie

Antibiotics (Basel)· February 2024

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Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency.
Bin Lu, Qi Qiao, Elizabeth R Park, Yuxuan Wang, John A Gilleran, Jacques Y Roberge

ACS Omega· February 2023

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The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis.
Mona Pokharel, Paulina Konarzewska, Jacques Y Roberge, Gil-Soo Han, Yina Wang

Microbiol Spectr· October 2022

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Ym155 localizes to the mitochondria leading to mitochondria dysfunction and activation of AMPK that inhibits BMP signaling in lung cancer cells.
Arindam Mondal, Dongxuan Jia, Vrushank Bhatt, Moumen Akel, Jacques Roberge

Sci Rep· July 2022

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Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells.
Arindam Mondal, Jacques Roberge, John Gilleran, Youyi Peng, Dongxuan Jia

Cell Commun Signal· June 2022

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TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens.
Eric J Bryan, Hye Yeon Sagong, Ajit K Parhi, Mark C Grier, Jacques Y Roberge

Antibiotics (Basel)· May 2022

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Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans.
Mehul Vora, Arindam Mondal, Dongxuan Jia, Pranya Gaddipati, Moumen Akel, Jacques Roberge

Cell Biosci· May 2022

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Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.
Xiao-Ping Li, Rajesh K Harijan, Bin Cao, Jennifer N Kahn, Michael Pierce, Jacques Y Roberge

J Med Chem· October 2021

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Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells.
Arindam Mondal, Rachel NeMoyer, Mehul Vora, Logan Napoli, Zoya Syed, Jacques Roberge

Cell Commun Signal· September 2021

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Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice.
Eileen Carry, Dushyant Kshatriya, Joshua Silva, Daryl L Davies, Bo Yuan, Jacques Roberge

Int J Mol Sci· July 2021

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A Novel Dual Drug Approach That Combines Ivermectin and Dihydromyricetin (DHM) to Reduce Alcohol Drinking and Preference in Mice.
Joshua Silva, Eileen Carry, Chen Xue, Jifeng Zhang, Jing Liang, Jacques Y Roberge

Molecules· March 2021

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Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
John A Gilleran, Xin Yu, Alan J Blayney, Anthony F Bencivenga, Bing Na, Jacques Y Roberge

J Med Chem· February 2021

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Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.
Ge Xu, Binhua Lv, Jacques Y Roberge, Baihua Xu, Jiyan Du

J Med Chem· February 2014

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Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.
Hannguang Chao, Huji Turdi, Timothy F Herpin, Jacques Y Roberge, Yalei Liu

J Med Chem· February 2013

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C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Baihua Xu, Yan Feng, Huawei Cheng, Yanli Song, Binhua Lv, Jacques Y Roberge

Bioorg Med Chem Lett· August 2011

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EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.
Wenbin Zhang, Ajith Welihinda, Jordan Mechanic, Haifeng Ding, Liangcheng Zhu, Jacques Y Roberge

Pharmacol Res· April 2011

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Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.
Jacques Y Roberge, Lalgudi S Harikrishnan, Muthoni G Kamau, Zheming Ruan, Katy Van Kirk

J Comb Chem· February 2009

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Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.
Ashvinikumar V Gavai, Roy J Vaz, Amarendra B Mikkilineni, Jacques Y Roberge, Yalei Liu

Bioorg Med Chem Lett· December 2005

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